Epigenetic modifiers: basic understanding and clinical development. (Q45976173)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19509169%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

title

Epigenetic modifiers: basic understanding and clinical development (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19509169%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Susan E Bates

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30 January 2020

Richard L Piekarz

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30 January 2020

language of work or name

English

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publication date

9 June 2009

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30 January 2020

published in

Clinical Cancer Research

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30 January 2020

volume

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30 January 2020

issue

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30 January 2020

page(s)

3918-3926

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Regulation of the HIF-1alpha stability by histone deacetylases

30 January 2020

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12 December 2020

Activity of suberoylanilide hydroxamic Acid against human breast cancer cells with amplification of her-2.

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Histone deacetylase inhibitors specifically kill nonproliferating tumour cells

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Histone deacetylase (HDAC) inhibitor LBH589 increases duration of gamma-H2AX foci and confines HDAC4 to the cytoplasm in irradiated non-small cell lung cancer

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5-Azacytidine Selectively Increases γ-Globin Synthesis in a Patient with β+Thalassemia

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Acetylation of non-histone proteins modulates cellular signalling at multiple levels

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12 December 2020

Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines.

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Differentiation of human leukemic leukocytes in tissue culture

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12 December 2020

Acetylation of p53 at lysine 373/382 by the histone deacetylase inhibitor depsipeptide induces expression of p21(Waf1/Cip1).

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Cancer DNA methylation: molecular mechanisms and clinical implications

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Phase I trial of MS-275, a histone deacetylase inhibitor, administered weekly in refractory solid tumors and lymphoid malignancies

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Approval summary: azacitidine for treatment of myelodysplastic syndrome subtypes

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Histone deacetylase interacts directly with DNA topoisomerase II

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12 December 2020

Histone deacetylase inhibitor LAQ824 down-regulates Her-2 and sensitizes human breast cancer cells to trastuzumab, taxotere, gemcitabine, and epothilone B

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12 December 2020

Histone deacetylase inhibitors sensitize prostate cancer cells to agents that produce DNA double-strand breaks by targeting Ku70 acetylation.

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Inhibition of DNA methyltransferase and induction of Friend erythroleukemia cell differentiation by 5-azacytidine and 5-aza-2'-deoxycytidine

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Induction of MAGE-3 expression in lung and esophageal cancer cells

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Heat shock protein 90 as a drug target: some like it hot.

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Nuclear factor-kappaB p65 small interfering RNA or proteasome inhibitor bortezomib sensitizes head and neck squamous cell carcinomas to classic histone deacetylase inhibitors and novel histone deacetylase inhibitor PXD101.

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12 December 2020

Aggresome induction by proteasome inhibitor bortezomib and alpha-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells

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12 December 2020

Increased MDR1 expression in normal and malignant peripheral blood mononuclear cells obtained from patients receiving depsipeptide (FR901228, FK228, NSC630176).

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12 December 2020

Synthesis of benzamide derivatives of anacardic acid and their cytotoxic activity

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12 December 2020

Histone deacetylase (HDAC) inhibitor activation of p21WAF1 involves changes in promoter-associated proteins, including HDAC1

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12 December 2020

Combined effects of novel tyrosine kinase inhibitor AMN107 and histone deacetylase inhibitor LBH589 against Bcr-Abl-expressing human leukemia cells

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12 December 2020

Modifying histones to tame cancer: clinical development of sodium phenylbutyrate and other histone deacetylase inhibitors

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12 December 2020

The consensus coding sequences of human breast and colorectal cancers

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12 December 2020

Histone deacetylase inhibitors sensitize human colonic adenocarcinoma cell lines to TNF-related apoptosis inducing ligand-mediated apoptosis.

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12 December 2020

Effects of sodium butyrate on human chronic myelogenous leukaemia cell line K562

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12 December 2020

The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF1 1.

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12 December 2020

Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect.

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12 December 2020

Role of histone deacetylase inhibitor-induced reactive oxygen species and DNA damage in LAQ-824/fludarabine antileukemic interactions

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12 December 2020

FK228 inhibits Hsp90 chaperone function in K562 cells via hyperacetylation of Hsp70

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12 December 2020

Cytotoxicity mediated by histone deacetylase inhibitors in cancer cells: mechanisms and potential clinical implications

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12 December 2020

Blockade of histone deacetylase inhibitor-induced RelA/p65 acetylation and NF-kappaB activation potentiates apoptosis in leukemia cells through a process mediated by oxidative damage, XIAP downregulation, and c-Jun N-terminal kinase 1 activation

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12 December 2020

Ku70 acetylation mediates neuroblastoma cell death induced by histone deacetylase inhibitors

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12 December 2020

Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation

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12 December 2020

Sequential 5-Aza-2 deoxycytidine-depsipeptide FR901228 treatment induces apoptosis preferentially in cancer cells and facilitates their recognition by cytolytic T lymphocytes specific for NY-ESO-1.

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12 December 2020

Differential protein acetylation induced by novel histone deacetylase inhibitors

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12 December 2020

Enhanced pharmacodynamic and antitumor properties of a histone deacetylase inhibitor encapsulated in liposomes or ErbB2-targeted immunoliposomes

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12 December 2020

Abrogation of p21 expression by flavopiridol enhances depsipeptide-mediated apoptosis in malignant pleural mesothelioma cells

1 reference

12 December 2020

Phase I trial of the histone deacetylase inhibitor, depsipeptide (FR901228, NSC 630176), in patients with refractory neoplasms

1 reference

12 December 2020

The cyclin-dependent kinase inhibitor flavopiridol disrupts sodium butyrate-induced p21WAF1/CIP1 expression and maturation while reciprocally potentiating apoptosis in human leukemia cells

1 reference

12 December 2020

Inhibition of histone deacetylase increases cytotoxicity to anticancer drugs targeting DNA

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12 December 2020

Role of multidrug transporters in pharmacoresistance to antiepileptic drugs

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12 December 2020

Mechanisms involved in the induced differentiation of leukemia cells

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12 December 2020

Effect of polar organic compounds on leukemic cells. Butyrate-induced partial remission of acute myelogenous leukemia in a child.

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12 December 2020

Histone deacetylase inhibitors radiosensitize human melanoma cells by suppressing DNA repair activity

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12 December 2020

Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug

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12 December 2020

Treatment of sickle cell anemia with 5-azacytidine results in increased fetal hemoglobin production and is associated with nonrandom hypomethylation of DNA around the gamma-delta-beta-globin gene complex

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12 December 2020

Functional striated muscle cells from non-myoblast precursors following 5-azacytidine treatment

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12 December 2020

Radiosensitizing potential of epigenetic anticancer drugs.

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12 December 2020

Effect of trichostatin A on cell growth and expression of cell cycle- and apoptosis-related molecules in human gastric and oral carcinoma cell lines.

1 reference

12 December 2020

It's about time: scheduling alters effect of histone deacetylase inhibitors on camptothecin-treated cells

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12 December 2020

The histone deacetylase inhibitor LAQ824 induces human leukemia cell death through a process involving XIAP down-regulation, oxidative injury, and the acid sphingomyelinase-dependent generation of ceramide

1 reference

12 December 2020

MS-275, a novel histone deacetylase inhibitor with selectivity against HDAC1, induces degradation of FLT3 via inhibition of chaperone function of heat shock protein 90 in AML cells

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12 December 2020

Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor

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12 December 2020

Induction of apoptosis in renal tubular cells by histone deacetylase inhibitors, a family of anticancer agents

1 reference

12 December 2020

Multiple new phenotypes induced in and 3T3 cells treated with 5-azacytidine

1 reference

12 December 2020

Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene

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12 December 2020

Cotreatment with histone deacetylase inhibitor LAQ824 enhances Apo-2L/tumor necrosis factor-related apoptosis inducing ligand-induced death inducing signaling complex activity and apoptosis of human acute leukemia cells

1 reference

12 December 2020

The roles of therapy-induced autophagy and necrosis in cancer treatment

1 reference

12 December 2020

Up-regulation of MDR1 and induction of doxorubicin resistance by histone deacetylase inhibitor depsipeptide (FK228) and ATRA in acute promyelocytic leukemia cells

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12 December 2020

Cellular differentiation, cytidine analogs and DNA methylation

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12 December 2020

PolyHEMA spheroids are an inadequate model for the drug resistance of the intractable solid tumors.

1 reference

12 December 2020

Effects of sodium butyrate, a new pharmacological agent, on cells in culture

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12 December 2020

5' CpG island hypermethylation is associated with transcriptional silencing of the p21(CIP1/WAF1/SDI1) gene and confers poor prognosis in acute lymphoblastic leukemia

1 reference

12 December 2020

Evidence of a functional role for p21WAF1/CIP1 down-regulation in synergistic antileukemic interactions between the histone deacetylase inhibitor sodium butyrate and flavopiridol

1 reference

12 December 2020

Targeting DNA methylation

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12 December 2020

Transcriptional regulation of the MDR1 gene by histone acetyltransferase and deacetylase is mediated by NF-Y.

1 reference

12 December 2020

Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma

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12 December 2020

Rational combinations using HDAC inhibitors

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12 December 2020

A phase II study of depsipeptide in refractory metastatic renal cell cancer

1 reference

12 December 2020

P21-dependent g(1)arrest with downregulation of cyclin D1 and upregulation of cyclin E by the histone deacetylase inhibitor FR901228

1 reference

12 December 2020

Plasma and cerebrospinal fluid pharmacokinetics of depsipeptide (FR901228) in nonhuman primates

1 reference

12 December 2020

Apoptotic and autophagic cell death induced by histone deacetylase inhibitors

1 reference

12 December 2020

Induction of erythropoietic colonies in a human chronic myelogenous leukemia cell line

1 reference

12 December 2020

Mechanisms of resistance to 5-aza-2'-deoxycytidine in human cancer cell lines

1 reference

12 December 2020

The histone deacetylase inhibitor sodium butyrate induces DNA topoisomerase II alpha expression and confers hypersensitivity to etoposide in human leukemic cell lines

1 reference

12 December 2020

Histone modifications at the ABCG2 promoter following treatment with histone deacetylase inhibitor mirror those in multidrug-resistant cells

1 reference

12 December 2020

DNA methylation profiling of human chromosomes 6, 20 and 22

1 reference

12 December 2020

Actions of a histone deacetylase inhibitor NSC3852 (5-nitroso-8-quinolinol) link reactive oxygen species to cell differentiation and apoptosis in MCF-7 human mammary tumor cells

1 reference

12 December 2020

Inhibitors of histone deacetylases alter kinetochore assembly by disrupting pericentromeric heterochromatin.

1 reference

12 December 2020

Phase 1 and pharmacologic study of MS-275, a histone deacetylase inhibitor, in adults with refractory and relapsed acute leukemias

1 reference

12 December 2020

10.1158/1078-0432.CCR-08-2788

Identifiers

DOI

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30 January 2020

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24 November 2022

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30 January 2020

PubMed publication ID

19509169

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19509169%20AND%20SRC:MED&resulttype=core&format=json