Artificial microRNA interference targeting AT(1a) receptors in paraventricular nucleus attenuates hypertension in rats (Q45873654)

17 December 2017

title

Artificial microRNA interference targeting AT(1a) receptors in paraventricular nucleus attenuates hypertension in rats (English)

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17 December 2017

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17 December 2017

author name string

Z-D Fan

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17 December 2017

L Zhang

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17 December 2017

Z Shi

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17 December 2017

X-B Gan

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17 December 2017

X-Y Gao

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17 December 2017

publication date

29 September 2011

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17 December 2017

published in

Gene Therapy

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17 December 2017

volume

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17 December 2017

issue

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17 December 2017

page(s)

810-817

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17 December 2017

Sympathetic activation in the pathogenesis of hypertension and progression of organ damage

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Essential hypertension

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Sympathetic nervous system modulation of inflammation and remodeling in the hypertensive heart

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Therapeutic strategies for targeting excessive central sympathetic activation in human hypertension

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Paraventricular nucleus, stress response, and cardiovascular disease

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Inhibition of the hypothalamic paraventricular nucleus in spontaneously hypertensive rats dramatically reduces sympathetic vasomotor tone

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Glutamatergic inputs in the hypothalamic paraventricular nucleus maintain sympathetic vasomotor tone in hypertension

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Lesions of the paraventricular nucleus alter the development of spontaneous hypertension in the rat.

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Sympathetic inhibition and attenuation of spontaneous hypertension by PVN lesions in rats

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Upregulation of angiotensin AT1 receptor and intracellular kinase gene expression in hypertensive rats

21 January 2018

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Angiotensin AT1 receptors in paraventricular nucleus contribute to sympathetic activation and enhanced cardiac sympathetic afferent reflex in renovascular hypertensive rats

21 January 2018

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Divergent functions of angiotensin II receptor isoforms in the brain

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Adenoviral inhibition of AT1a receptors in the paraventricular nucleus inhibits acute increases in mean arterial blood pressure in the rat

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Plasma catecholamines and essential hypertension. An analytical review

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Enhanced cardiac sympathetic afferent reflex involved in sympathetic overactivity in renovascular hypertensive rats

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Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensin-aldosterone system

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Evaluation of medial hypertrophy in resistance vessels of spontaneously hypertensive rats

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Vascular remodeling in hypertension: roles of apoptosis, inflammation, and fibrosis

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Prenatal and postnatal hydralazine treatment does not prevent renal vessel wall thickening in SHR despite the absence of hypertension.

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Relationship between central sympathetic drive and magnetic resonance imaging-determined left ventricular mass in essential hypertension

21 January 2018

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Adenovirus-mediated small-interference RNA for in vivo silencing of angiotensin AT1a receptors in mouse brain

21 January 2018

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Subfornical organ mediates pressor effect of angiotensin: Influence of nitric oxide synthase inhibitors, AT(1) and AT(2) angiotensin antagonist's receptors

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Enhanced angiotensin-mediated responses in the nucleus tractus solitarii of spontaneously hypertensive rats

21 January 2018

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Activation of hypothalamic angiotensin receptors produces pressor responses via cholinergic inputs to the rostral ventrolateral medulla in normotensive and hypertensive rats

21 January 2018

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A model system for in vivo gene transfer into the central nervous system using an adenoviral vector

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Physiological and tissue-specific vectors for treatment of inherited diseases

21 January 2018

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The angiotensin receptor subtype AT1A predominates in rat forebrain areas involved in blood pressure, body fluid homeostasis and neuroendocrine control

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2011.145

Selective silencing of angiotensin receptor subtype 1a (AT1aR) by RNA interference

21 January 2018

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Angiotensin II actions in paraventricular nucleus: functional evidence for neurotransmitter role in efferents originating in subfornical organ

21 January 2018

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AAV-mediated knockdown of peripherin-2 in vivo using miRNA-based hairpins

21 January 2018

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Specific gene silencing by artificial MicroRNAs in Physcomitrella patens: an alternative to targeted gene knockouts

21 January 2018

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Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: implications for the therapeutic development of RNAi

21 January 2018

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Control of translation and mRNA degradation by miRNAs and siRNAs

21 January 2018

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Long-term administration of tempol attenuates postinfarct ventricular dysfunction and sympathetic activity in rats

21 January 2018

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Heart-specific inhibition of protooncogene c-myc attenuates cold-induced cardiac hypertrophy

21 January 2018

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K(ATP) activation prevents progression of cardiac hypertrophy to failure induced by pressure overload via protecting endothelial function

21 January 2018

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Cardiovascular effects of arginase inhibition in spontaneously hypertensive rats with fully developed hypertension

21 January 2018

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Sympathoexcitation by oxidative stress in the brain mediates arterial pressure elevation in obesity-induced hypertension

21 January 2018

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Effects of arterial vasodilators on cardiac hypertrophy and sympathetic activity in rats

21 January 2018

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7 January 2021

Chronic antisense therapy for angiotensinogen on cardiac hypertrophy in spontaneously hypertensive rats

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https://api.crossref.org/works/10.1038%2FGT.2011.145

7 January 2021

Losartan, nonpeptide angiotensin II-type 1 (AT1) receptor antagonist, attenuates pressor and sympathoexcitatory responses evoked by angiotensin II and L-glutamate in rostral ventrolateral medulla

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.145

7 January 2021

Targeting brain AT1 receptors by RNA interference

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https://api.crossref.org/works/10.1038%2FGT.2011.145

7 January 2021

Identifiers

DOI

10.1038/GT.2011.145

1 reference

17 December 2017

Dimensions Publication ID

1043478876

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Fatcat ID

release_buh577iyl5g4rpcrqi7s2r5g6q

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Fatcat

https://api.fatcat.wiki/v0/release/buh577iyl5g4rpcrqi7s2r5g6q

24 November 2022

mapped directly with Wikidata item

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17 December 2017