Switching the fiber knob of oncolytic adenoviruses to avoid neutralizing antibodies in human cancer patients (Q45869559)

17 December 2017

title

Switching the fiber knob of oncolytic adenoviruses to avoid neutralizing antibodies in human cancer patients (English)

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17 December 2017

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17 December 2017

Akseli Hemminki

object named as

Akseli Hemminki

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17 December 2017

Timo Joensuu

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Minna Oksanen

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Sophie Escutenaire

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Anna Kanerva

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Lotta Kangasniemi

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Sari Pesonen

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Sari Pesonen

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17 December 2017

author name string

Mari Raki

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17 December 2017

Merja Sarkioja

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17 December 2017

Elina Haavisto

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17 December 2017

publication date

1 May 2011

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17 December 2017

published in

Journal of Gene Medicine

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17 December 2017

volume

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issue

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page(s)

253-261

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Oncolytic viruses in cancer therapy

cites work

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Using a tropism-modified adenoviral vector to circumvent inhibitory factors in ascites fluid

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An adenovirus with enhanced infectivity mediates molecular chemotherapy of ovarian cancer cells and allows imaging of gene expression

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Gene transfer to ovarian cancer versus normal tissues with fiber-modified adenoviruses

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Hexon gene switch strategy for the generation of chimeric recombinant adenovirus

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Adenoviruses with an RGD-4C modification of the fiber knob elicit a neutralizing antibody response but continue to allow enhanced gene delivery

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Neutralizing antibodies to adenovirus serotype 5 vaccine vectors are directed primarily against the adenovirus hexon protein

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Use of chimeric adenoviral vectors to assess capsid neutralization determinants.

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Hexon-chimaeric adenovirus serotype 5 vectors circumvent pre-existing anti-vector immunity

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Changing the adenovirus fiber for retaining gene delivery efficacy in the presence of neutralizing antibodies

21 January 2018

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Antipeptide antisera define neutralizing epitopes on the adenovirus hexon

21 January 2018

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Structure-based identification of a major neutralizing site in an adenovirus hexon

21 January 2018

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Identification of adenovirus (ad) penton base neutralizing epitopes by use of sera from patients who had received conditionally replicative ad (addl1520) for treatment of liver tumors

21 January 2018

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Decreased immune reactivity towards a knobless, affibody-targeted adenovirus type 5 vector

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Mapping of linear epitopes on fibre knob of human adenovirus serotype 5.

21 January 2018

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An advanced generation of adenoviral vectors selectively enhances gene transfer for ovarian cancer gene therapy approaches

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Infectivity-enhanced adenoviruses deliver efficacy in clinical samples and orthotopic models of disseminated gastric cancer

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Noninvasive imaging for evaluation of the systemic delivery of capsid-modified adenoviruses in an orthotopic model of advanced lung cancer

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Oncolytic adenovirus coding for granulocyte macrophage colony-stimulating factor induces antitumoral immunity in cancer patients

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Treatment of cancer patients with a serotype 5/3 chimeric oncolytic adenovirus expressing GMCSF.

21 January 2018

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Triple-targeted oncolytic adenoviruses featuring the cox2 promoter, E1A transcomplementation, and serotype chimerism for enhanced selectivity for ovarian cancer cells

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Prolonged systemic circulation of chimeric oncolytic adenovirus Ad5/3-Cox2L-D24 in patients with metastatic and refractory solid tumors

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A modified E2F-1 promoter improves the efficacy to toxicity ratio of oncolytic adenoviruses.

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Oncolytic adenovirus ICOVIR-7 in patients with advanced and refractory solid tumors

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A mutant oncolytic adenovirus targeting the Rb pathway produces anti-glioma effect in vivo.

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Double modification of adenovirus fiber with RGD and polylysine motifs improves coxsackievirus-adenovirus receptor-independent gene transfer efficiency

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Cryo-EM visualization of an exposed RGD epitope on adenovirus that escapes antibody neutralization

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Preclinical Characterization of the Antiglioma Activity of a Tropism-Enhanced Adenovirus Targeted to the Retinoblastoma Pathway

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Enhanced therapeutic efficacy for ovarian cancer with a serotype 3 receptor-targeted oncolytic adenovirus

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Phase II Trial of Intravenous CI-1042 in Patients With Metastatic Colorectal Cancer

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Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14.

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Clinical research results with dl1520 (Onyx-015), a replication-selective adenovirus for the treatment of cancer: what have we learned?

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Intravascular adenoviral agents in cancer patients: lessons from clinical trials

21 January 2018

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Conserved CTL epitopes on the adenovirus hexon protein expand subgroup cross-reactive and subgroup-specific CD8+ T cells

21 January 2018

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Human CD8+ cytotoxic T cell responses to adenovirus capsid proteins.

21 January 2018

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Identification of hexon-specific CD4 and CD8 T-cell epitopes for vaccine and immunotherapy

21 January 2018

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A smart move against cancer for vaccinia virus

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In situ adenovirus vaccination engages T effector cells against cancer

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Identifiers

DOI

10.1002/JGM.1565

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17 December 2017

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17 December 2017