Hexamethylbisacetamide and disruption of human immunodeficiency virus type 1 latency in CD4(+) T cells (Q45395775)

14 December 2017

title

Hexamethylbisacetamide and disruption of human immunodeficiency virus type 1 latency in CD4(+) T cells (English)

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14 December 2017

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14 December 2017

Shailesh K Choudhary

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14 December 2017

Nancy M Archin

series ordinal

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14 December 2017

language of work or name

English

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publication date

1 April 2008

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Journal of Infectious Diseases

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inferred from page(s)

published in

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14 December 2017

volume

197

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14 December 2017

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14 December 2017

page(s)

1162-1170

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Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells.

14 December 2017

cites work

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Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy

21 January 2018

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Intensification and stimulation therapy for human immunodeficiency virus type 1 reservoirs in infected persons receiving virally suppressive highly active antiretroviral therapy

21 January 2018

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OKT3 and IL-2 treatment for purging of the latent HIV-1 reservoir in vivo results in selective long-lasting CD4+ T cell depletion.

21 January 2018

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Coaxing HIV-1 from resting CD4 T cells: histone deacetylase inhibition allows latent viral expression

21 January 2018

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Administration of HDAC inhibitors to reactivate HIV-1 expression in latent cellular reservoirs: implications for the development of therapeutic strategies

21 January 2018

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Host cell gene expression during human immunodeficiency virus type 1 latency and reactivation and effects of targeting genes that are differentially expressed in viral latency

21 January 2018

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Interleukin-7 induces HIV type 1 outgrowth from peripheral resting CD4+ T cells

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Depletion of latent HIV-1 infection in vivo: a proof-of-concept study

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Hexamethylbisacetamide remodels the human immunodeficiency virus type 1 (HIV-1) promoter and induces Tat-independent HIV-1 expression but blunts cell activation

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The multifactorial nature of HIV-1 latency

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The human factors YY1 and LSF repress the human immunodeficiency virus type 1 long terminal repeat via recruitment of histone deacetylase 1.

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Counterregulation of chromatin deacetylation and histone deacetylase occupancy at the integrated promoter of human immunodeficiency virus type 1 (HIV-1) by the HIV-1 repressor YY1 and HIV-1 activator Tat

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Polyamides reveal a role for repression in latency within resting T cells of HIV-infected donors

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NF-kappaB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation

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c-Myc and Sp1 contribute to proviral latency by recruiting histone deacetylase 1 to the human immunodeficiency virus type 1 promoter

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Analysis of human immunodeficiency virus type 1 transcriptional elongation in resting CD4+ T cells in vivo

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Stochastic gene expression in a lentiviral positive-feedback loop: HIV-1 Tat fluctuations drive phenotypic diversity

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Mitogen-activated protein kinases regulate LSF occupancy at the human immunodeficiency virus type 1 promoter

21 January 2018

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Transcriptional profiles of latent human immunodeficiency virus in infected individuals: effects of Tat on the host and reservoir

21 January 2018

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A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA

21 January 2018

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P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro

21 January 2018

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Protein kinase C isoforms in murine erythroleukemia cells and their involvement in the differentiation process.

21 January 2018

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Flavopiridol inhibits P-TEFb and blocks HIV-1 replication

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Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo

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Upregulation of cyclin T1/CDK9 complexes during T cell activation

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Effects of prostratin on Cyclin T1/P-TEFb function and the gene expression profile in primary resting CD4+ T cells

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Modulation of a P-TEFb functional equilibrium for the global control of cell growth and differentiation

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Interplay between 7SK snRNA and oppositely charged regions in HEXIM1 direct the inhibition of P-TEFb

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7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes

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Controlling the elongation phase of transcription with P-TEFb

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The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis

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A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases.

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Tat and trans-activation-responsive (TAR) RNA-independent induction of HIV-1 long terminal repeat by human and murine cyclin T1 requires Sp1.

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NF-kappaB binds P-TEFb to stimulate transcriptional elongation by RNA polymerase II.

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NF-kappa B-dependent and -independent pathways of HIV activation in a chronically infected T cell line

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Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186

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Phosphorylation of the RNA polymerase II carboxyl-terminal domain by CDK9 is directly responsible for human immunodeficiency virus type 1 Tat-activated transcriptional elongation

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Elongation by RNA polymerase II: the short and long of it

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Tat modifies the activity of CDK9 to phosphorylate serine 5 of the RNA polymerase II carboxyl-terminal domain during human immunodeficiency virus type 1 transcription

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Identification of a cyclin T-binding domain in Hexim1 and biochemical analysis of its binding competition with HIV-1 Tat

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Phosphorylated positive transcription elongation factor b (P-TEFb) is tagged for inhibition through association with 7SK snRNA.

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Regulation of polymerase II transcription by 7SK snRNA: two distinct RNA elements direct P-TEFb and HEXIM1 binding

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Identifiers

DOI

10.1086/529525

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14 December 2017

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