Plastin 3 ameliorates spinal muscular atrophy via delayed axon pruning and improves neuromuscular junction functionality. (Q45350511)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23263861%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

title

Plastin 3 ameliorates spinal muscular atrophy via delayed axon pruning and improves neuromuscular junction functionality (English)

1 reference

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21 February 2020

main subject

spinal muscular atrophy

1 reference

based on heuristic

inferred from title

Plastin 3 (T-isoform)

1 reference

GOA release 2020-03-11

neuromuscular junction

1 reference

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23263861%20AND%20SRC:MED&resulttype=core&format=json

Seyyed Mohsen Hosseini Barkooie

21 February 2020

1 reference

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21 February 2020

1 reference

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21 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23263861%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

Bastian Ackermann

1 reference

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21 February 2020

Sandra Kröber

1 reference

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21 February 2020

Laura Torres-Benito

1 reference

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21 February 2020

Anke Borgmann

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23263861%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

Miriam Peters

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23263861%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

Miriam Jakubik

1 reference

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21 February 2020

Julia Schreml

1 reference

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21 February 2020

Janine Milbradt

1 reference

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21 February 2020

Thomas F Wunderlich

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23263861%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

Brunhilde Wirth

1 reference

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21 February 2020

publication date

20 December 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23263861%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

published in

Human Molecular Genetics

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21 February 2020

volume

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21 February 2020

issue

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21 February 2020

page(s)

1328-1347

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Agrin mediates cell contact-induced acetylcholine receptor clustering

21 February 2020

cites work

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Concerns about the design of clinical trials for spinal muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Natural history of denervation in SMA: relation to age, SMN2 copy number, and function

21 January 2018

1 reference

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Knockdown of the survival motor neuron (Smn) protein in zebrafish causes defects in motor axon outgrowth and pathfinding.

21 January 2018

1 reference

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Selective vulnerability of motor neurons and dissociation of pre- and post-synaptic pathology at the neuromuscular junction in mouse models of spinal muscular atrophy

21 January 2018

1 reference

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Smn, the spinal muscular atrophy-determining gene product, modulates axon growth and localization of beta-actin mRNA in growth cones of motoneurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

SAHA ameliorates the SMA phenotype in two mouse models for spinal muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Impaired synaptic vesicle release and immaturity of neuromuscular junctions in spinal muscular atrophy mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Altered intracellular Ca2+ homeostasis in nerve terminals of severe spinal muscular atrophy mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

SMN requirement for synaptic vesicle, active zone and microtubule postnatal organization in motor nerve terminals

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Identification and characterization of a spinal muscular atrophy-determining gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Quantitative analyses of SMN1 and SMN2 based on real-time lightCycler PCR: fast and highly reliable carrier testing and prediction of severity of spinal muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

A novel function for SMN, the spinal muscular atrophy disease gene product, in pre-mRNA splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Inactivation of the SMN complex by oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Plastin 3 is a protective modifier of autosomal recessive spinal muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Survival motor neuron affects plastin 3 protein levels leading to motor defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

The contribution of mouse models to understanding the pathogenesis of spinal muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Dual pools of actin at presynaptic terminals

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

The spinal muscular atrophy disease protein SMN is linked to the Rho-kinase pathway via profilin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Severe neuromuscular denervation of clinically relevant muscles in a mouse model of spinal muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Functional differences between L- and T-plastin isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

A mouse model for spinal muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Identification of a battery of tests for drug candidate evaluation in the SMNDelta7 neonate model of spinal muscular atrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Rho-kinase inactivation prolongs survival of an intermediate SMA mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Development of the vertebrate neuromuscular junction

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Synapse elimination and indelible memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Embryonic motor axon development in the severe SMA mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

SMN complex localizes to the sarcomeric Z-disc and is a proteolytic target of calpain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Early Functional Impairment of Sensory-Motor Connectivity in a Mouse Model of Spinal Muscular Atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Patterning of muscle acetylcholine receptor gene expression in the absence of motor innervation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

SMN, profilin IIa and plastin 3: a link between the deregulation of actin dynamics and SMA pathogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Low bone mineral density in spinal muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Congenital heart disease is a feature of severe infantile spinal muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Density, calibre and ramification of muscle capillaries are altered in a mouse model of severe spinal muscular atrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Deletion of murine Smn exon 7 directed to liver leads to severe defect of liver development associated with iron overload

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

SMN deficiency disrupts brain development in a mouse model of severe spinal muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Arrhythmia and cardiac defects are a feature of spinal muscular atrophy model mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Early heart failure in the SMNDelta7 model of spinal muscular atrophy and correction by postnatal scAAV9-SMN delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Cardiac defects contribute to the pathology of spinal muscular atrophy models

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Piccolo regulates the dynamic assembly of presynaptic F-actin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Synaptic vesicle phosphoproteins and regulation of synaptic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Actin-dependent regulation of neurotransmitter release at central synapses

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Actin in action: the interplay between the actin cytoskeleton and synaptic efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Synaptic defects in spinal muscular atrophy animal models

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Antisense oligonucleotides delivered to the mouse CNS ameliorate symptoms of severe spinal muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

RETRACTED ARTICLE: Rescue of the spinal muscular atrophy phenotype in a mouse model by early postnatal delivery of SMN

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Intravenous scAAV9 delivery of a codon-optimized SMN1 sequence rescues SMA mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Peripheral SMN restoration is essential for long-term rescue of a severe spinal muscular atrophy mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

A single administration of morpholino antisense oligomer rescues spinal muscular atrophy in mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Postsymptomatic restoration of SMN rescues the disease phenotype in a mouse model of severe spinal muscular atrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

The actin cytoskeleton: integrating form and function at the synapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

The actin-driven movement and formation of acetylcholine receptor clusters

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Failure of postsynaptic specialization to develop at neuromuscular junctions of rapsyn-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

The function of cortactin in the clustering of acetylcholine receptors at the vertebrate neuromuscular junction

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Plastin family of actin-bundling proteins: its functions in leukocytes, neurons, intestines, and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Ability of the hydrophobic FGF and basic TAT peptides to promote cellular uptake of recombinant Cre recombinase: a tool for efficient genetic engineering of mammalian genomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Simplified mammalian DNA isolation procedure

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Detection of specific sequences among DNA fragments separated by gel electrophoresis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Valproic acid increases the SMN2 protein level: a well-known drug as a potential therapy for spinal muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

Ultrastructural changes in diaphragm neuromuscular junctions in a severe mouse model for Spinal Muscular Atrophy and their prevention by bifunctional U7 snRNA correcting SMN2 splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS540

21 January 2018

Identifiers

DOI

10.1093/HMG/DDS540

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23263861%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23263861%20AND%20SRC:MED&resulttype=core&format=json