Inhibition of topoisomerase II α activity and induction of apoptosis in mammalian cells by semi-synthetic andrographolide analogues (Q45349901)

13 December 2017

title

Inhibition of topoisomerase II α activity and induction of apoptosis in mammalian cells by semi-synthetic andrographolide analogues (English)

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13 December 2017

author name string

Jintapat Nateewattana

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13 December 2017

Rungnapha Saeeng

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13 December 2017

Sakkasem Kasemsook

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13 December 2017

Kanoknetr Suksen

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13 December 2017

Suman Dutta

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13 December 2017

Surawat Jariyawat

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13 December 2017

Arthit Chairoungdua

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13 December 2017

Apichart Suksamrarn

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13 December 2017

Pawinee Piyachaturawat

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13 December 2017

language of work or name

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17 August 2012

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Investigational New Drugs

13 December 2017

published in

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13 December 2017

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13 December 2017

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13 December 2017

page(s)

320-332

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DNA topoisomerase II enzymes as molecular targets for cancer chemotherapy

13 December 2017

cites work

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21 January 2018

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Benzylidene derivatives of andrographolide inhibit growth of breast and colon cancer cells in vitro by inducing G(1) arrest and apoptosis

21 January 2018

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Semisynthesis and cytotoxic activities of andrographolide analogues

21 January 2018

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21 January 2018

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21 January 2018

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Andrographolide induces cell cycle arrest at G2/M phase and cell death in HepG2 cells via alteration of reactive oxygen species.

21 January 2018

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Critical role of pro-apoptotic Bcl-2 family members in andrographolide-induced apoptosis in human cancer cells.

21 January 2018

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Apoptosis: a relevant tool for anticancer therapy

21 January 2018

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Inhibition of cellular proliferation by diterpenes, topoisomerase II inhibitor.

21 January 2018

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Characterization of a Chinese hamster ovary cell line with acquired resistance to the bisdioxopiperazine dexrazoxane (ICRF-187) catalytic inhibitor of topoisomerase II

21 January 2018

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3,3'-diindolylmethane is a novel topoisomerase IIalpha catalytic inhibitor that induces S-phase retardation and mitotic delay in human hepatoma HepG2 cells

21 January 2018

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Increased cytotoxicity of an unusual DNA topoisomerase II inhibitor compound C-1305 toward HeLa cells with downregulated PARP-1 activity results from re-activation of the p53 pathway and modulation of mitotic checkpoints.

21 January 2018

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The novel silatecan 7-tert-butyldimethylsilyl-10-hydroxycamptothecin displays high lipophilicity, improved human blood stability, and potent anticancer activity

21 January 2018

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Topoisomerase I inhibitors and drug resistance

21 January 2018

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Riccardin D, a novel macrocyclic bisbibenzyl, induces apoptosis of human leukemia cells by targeting DNA topoisomerase II.

21 January 2018

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NK314, a novel topoisomerase II inhibitor, induces rapid DNA double-strand breaks and exhibits superior antitumor effects against tumors resistant to other topoisomerase II inhibitors

21 January 2018

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Clinical applications of anticancer drugs targeted to topoisomerase II

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/22899371

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Critical roles of cellular glutathione homeostasis and jnk activation in andrographolide‐mediated apoptotic cell death in human hepatoma cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22899371

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

DNA topoisomerases as anticancer drug targets

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22899371

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S10637-012-9868-9

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Dimensions Publication ID

13 December 2017

1044503294

0 references

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