Two isoforms of glutamate decarboxylase: why? (Q45345778)

13 December 2017

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title

Two isoforms of glutamate decarboxylase: why? (English)

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13 December 2017

author

Jean-jacques Soghomonian

series ordinal

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13 December 2017

Martin DL

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13 December 2017

language of work or name

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1 December 1998

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Trends in Pharmacological Sciences

13 December 2017

published in

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13 December 2017

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13 December 2017

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13 December 2017

page(s)

500-505

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Brain glutamate decarboxylase cloned in lambda gt-11: fusion protein produces gamma-aminobutyric acid

13 December 2017

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Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene

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7 January 2021

Structure and the promoter region of the mouse gene encoding the 67-kD form of glutamic acid decarboxylase

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7 January 2021

Comparative localization of two forms of glutamic acid decarboxylase and their mRNAs in rat brain supports the concept of functional differences between the forms

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7 January 2021

Different distributions of GAD65 and GAD67 mRNAs suggest that the two glutamate decarboxylases play distinctive functional roles.

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Membrane anchoring of the autoantigen GAD65 to microvesicles in pancreatic beta-cells by palmitoylation in the NH2-terminal domain

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Association of GAD-65, but not of GAD-67, with the Golgi complex of transfected Chinese hamster ovary cells mediated by the N-terminal region

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Amino acid residues 24-31 but not palmitoylation of cysteines 30 and 45 are required for membrane anchoring of glutamic acid decarboxylase, GAD65

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Targeting of the 67-kDa isoform of glutamic acid decarboxylase to intracellular organelles is mediated by its interaction with the NH2-terminal region of the 65-kDa isoform of glutamic acid decarboxylase

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7 January 2021

Phosphorylation of serine residues 3, 6, 10, and 13 distinguishes membrane anchored from soluble glutamic acid decarboxylase 65 and is restricted to glutamic acid decarboxylase 65alpha

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Motifs and structural fold of the cofactor binding site of human glutamate decarboxylase

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7 January 2021

A signal located within amino acids 1-27 of GAD65 is required for its targeting to the Golgi complex region

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7 January 2021

Two forms of the gamma-aminobutyric acid synthetic enzyme glutamate decarboxylase have distinct intraneuronal distributions and cofactor interactions.

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Regulation of gamma-aminobutyric acid synthesis in the brain

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Regulatory properties of brain glutamate decarboxylase (GAD): the apoenzyme of GAD is present principally as the smaller of two molecular forms of GAD in brain

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7 January 2021

Cofactor interactions and the regulation of glutamate decarboxylase activity

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7 January 2021

Multiple elements regulate GAD65 transcription.

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7 January 2021

Structure and alternative promoters of the mouse glutamic acid decarboxylase 67 gene

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7 January 2021

Effects of increased gamma-aminobutyric acid levels on GAD67 protein and mRNA levels in rat cerebral cortex

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7 January 2021

The level of GAD67 protein is highly sensitive to small increases in intraneuronal gamma-aminobutyric acid levels.

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Mice lacking the 65 kDa isoform of glutamic acid decarboxylase (GAD65) maintain normal levels of GAD67 and GABA in their brains but are susceptible to seizures

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7 January 2021

Cleft palate and decreased brain gamma-aminobutyric acid in mice lacking the 67-kDa isoform of glutamic acid decarboxylase

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Depolarization by K+ and glutamate activates different neurotransmitter release mechanisms in GABAergic neurons: vesicular versus non-vesicular release of GABA

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7 January 2021

Glutamate decarboxylase immunoreactivity and gamma-[3H] aminobutyric acid accumulation within the same neurons in dissociated cell cultures of cerebral cortex

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GABA and pancreatic beta-cells: colocalization of glutamic acid decarboxylase (GAD) and GABA with synaptic-like microvesicles suggests their role in GABA storage and secretion.

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Depolarization without calcium can release gamma-aminobutyric acid from a retinal neuron

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Horizontal cells in cat and monkey retina express different isoforms of glutamic acid decarboxylase

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Displaced starburst amacrine cells of the rabbit retina contain the 67-kDa isoform, but not the 65-kDa isoform, of glutamate decarboxylase

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7 January 2021

The parafascicular thalamic nucleus modulates messenger RNA encoding glutamate decarboxylase 67 in rat striatum

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7 January 2021

Dopaminergic and glutamatergic blocking drugs differentially regulate glutamic acid decarboxylase mRNA in mouse brain

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7 January 2021

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7 January 2021

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7 January 2021

Changes in glutamic acid decarboxylase mRNA in the pallidum of the rat following unilateral damage of the striatum and overlying cortex

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7 January 2021

Increased glutamate decarboxylase mRNA levels in the striatum and pallidum of MPTP-treated primates.

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7 January 2021

Glutamate decarboxylase (GAD65) mRNA levels in the striatum and pallidum of MPTP-treated monkeys

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7 January 2021

Spontaneous firing patterns of identified spiny neurons in the rat neostriatum

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7 January 2021

Comparative distribution of messenger RNAs encoding glutamic acid decarboxylases (Mr 65,000 and Mr 67,000) in the basal ganglia of the rat.

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7 January 2021

The origins of two-state spontaneous membrane potential fluctuations of neostriatal spiny neurons.

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7 January 2021

Bursting and tonic discharges in two classes of reticular thalamic neurons

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7 January 2021

Functional dynamics of GABAergic inhibition in the thalamus.

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7 January 2021

Glutamate decarboxylase (GAD67 and GAD65) gene expression is increased in a subpopulation of neurons in the putamen of Parkinsonian monkeys

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7 January 2021

Glutamate decarboxylase messenger RNA in rat pallidum: Comparison of the effects of haloperidol, clozapine and combined haloperidol-scopolamine treatments

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7 January 2021

Differential regulation of mRNA levels encoding for the two isoforms of glutamate decarboxylase (GAD65 and GAD67) by dopamine receptors in the rat striatum

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7 January 2021

Acute versus chronic haloperidol: relationship between tolerance to catalepsy and striatal and accumbens dopamine, GABA and acetylcholine release

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7 January 2021

Regional specific effects of clozapine and haloperidol on GABA and dopamine release in rat basal ganglia

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7 January 2021

Influence of dopamine on GABA release in striatum: evidence for D1-D2 interactions and non-synaptic influences

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7 January 2021

Glutamate decarboxylase (GAD65) gene expression is increased by dopamine receptor agonists in a subpopulation of rat striatal neurons

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7 January 2021

D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons

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7 January 2021

Region-specific regulation of glutamic acid decarboxylase (GAD) mRNA expression in central stress circuits.

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7 January 2021

Increased GABAergic transmission in medial hypothalamus facilitates lordosis but has the opposite effect in preoptic area

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7 January 2021

Estrogen modulation of mRNA levels for the two forms of glutamic acid decarboxylase (GAD) in female rat brain

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7 January 2021

GABAergic neuronal activity and mRNA levels for both forms of glutamic acid decarboxylase (GAD65 and GAD67) are reduced in the diagonal band of Broca during the afternoon of proestrus

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7 January 2021

Intracerebral administration of antisense oligodeoxynucleotides to GAD65 and GAD67 mRNAs modulate reproductive behavior in the female rat.

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7 January 2021

Heteromers of glutamate decarboxylase isoforms occur in rat cerebellum

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7 January 2021

10.1016/S0165-6147(98)01270-X

Identifiers

DOI

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13 December 2017

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