Neuroprotection by Hsp104 and Hsp27 in lentiviral-based rat models of Huntington's disease (Q45304607)

11 December 2017

title

Neuroprotection by Hsp104 and Hsp27 in lentiviral-based rat models of Huntington's disease (English)

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11 December 2017

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11 December 2017

Nicole Déglon

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Ruth Luthi-Carter

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11 December 2017

Raymonde Hassig

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11 December 2017

Etienne Régulier

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11 December 2017

Valérie Perrin

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11 December 2017

Toufik Abbas-Terki

series ordinal

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11 December 2017

Patrick Aebischer

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11 December 2017

publication date

20 March 2007

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11 December 2017

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11 December 2017

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11 December 2017

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11 December 2017

page(s)

903-911

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

11 December 2017

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7 January 2021

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

Protein misfolding, amyloid formation, and neurodegeneration: a critical role for molecular chaperones?

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

Neuroprotective strategies for basal ganglia degeneration: Parkinson's and Huntington's diseases

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

Modulation of neurodegeneration by molecular chaperones

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

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Protective effect of chaperones on polyglutamine diseases

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

Analysis of the role of heat shock protein (Hsp) molecular chaperones in polyglutamine disease

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila.

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

Genetic suppression of polyglutamine toxicity in Drosophila

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

Chaperone suppression of cellular toxicity of huntingtin is independent of polyglutamine aggregation

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

Overexpression of heat shock protein 70 in R6/2 Huntington's disease mice has only modest effects on disease progression

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

Hsp70 and Hsp40 chaperones do not modulate retinal phenotype in SCA7 mice.

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

A chaperone pathway in protein disaggregation. Hsp26 alters the nature of protein aggregates to facilitate reactivation by Hsp104.

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

The structure of ClpB: a molecular chaperone that rescues proteins from an aggregated state

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

Bacterial and yeast chaperones reduce both aggregate formation and cell death in mammalian cell models of Huntington's disease

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

Hsp104, Hsp70, and Hsp40: a novel chaperone system that rescues previously aggregated proteins

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

Overexpression of yeast hsp104 reduces polyglutamine aggregation and prolongs survival of a transgenic mouse model of Huntington's disease

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

Progressive and selective striatal degeneration in primary neuronal cultures using lentiviral vector coding for a mutant huntingtin fragment

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

CA150 expression delays striatal cell death in overexpression and knock-in conditions for mutant huntingtin neurotoxicity.

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

Involvement of mitochondrial complex II defects in neuronal death produced by N-terminus fragment of mutated huntingtin

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

Lentiviral-mediated delivery of mutant huntingtin in the striatum of rats induces a selective neuropathology modulated by polyglutamine repeat size, huntingtin expression levels, and protein length.

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

Contribution of nuclear and extranuclear polyQ to neurological phenotypes in mouse models of Huntington's disease

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

Nuclear-targeting of mutant huntingtin fragments produces Huntington's disease-like phenotypes in transgenic mice

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

Huntingtin and the molecular pathogenesis of Huntington's disease. Fourth in molecular medicine review series

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

Loss of autophagy in the central nervous system causes neurodegeneration in mice

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

Pathophysiology of chaperone-mediated autophagy

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

Expression of the small heat-shock protein alphaB-crystallin in tauopathies with glial pathology

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

Desmin aggregate formation by R120G alphaB-crystallin is caused by altered filament interactions and is dependent upon network status in cells

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

Cytoskeletal competence requires protein chaperones.

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

Axonal transport failure in neurodegenerative disorders: the case of Huntington's disease

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

Hsp104 interacts with Hsp90 cochaperones in respiring yeast

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

Complete and long-term rescue of lesioned adult motoneurons by lentiviral-mediated expression of glial cell line-derived neurotrophic factor in the facial nucleus.

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

Cellular defects and altered gene expression in PC12 cells stably expressing mutant huntingtin

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

Neuroprotective effect of interleukin-6 and IL6/IL6R chimera in the quinolinic acid rat model of Huntington's syndrome

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https://api.crossref.org/works/10.1038%2FMT.SJ.6300141

7 January 2021

Identifiers

DOI

10.1038/MT.SJ.6300141

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11 December 2017

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