Dysregulation of REST-regulated coding and non-coding RNAs in a cellular model of Huntington's disease (Q45290680)

11 December 2017

title

Dysregulation of REST-regulated coding and non-coding RNAs in a cellular model of Huntington's disease (English)

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11 December 2017

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11 December 2017

Angela Bithell

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Chiara Soldati

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11 December 2017

Caroline Johnston

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11 December 2017

Kee-Yew Wong

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11 December 2017

Lawrence W Stanton

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11 December 2017

language of work or name

English

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publication date

1 February 2013

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Journal of Neurochemistry

11 December 2017

published in

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11 December 2017

volume

124

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11 December 2017

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11 December 2017

page(s)

418-430

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

11 December 2017

cites work

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Anterograde transport of brain-derived neurotrophic factor and its role in the brain

21 January 2018

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p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease

21 January 2018

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Huntingtin aggregation and toxicity in Huntington's disease

21 January 2018

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Transcriptional changes in Huntington disease identified using genome-wide expression profiling and cross-platform analysis

21 January 2018

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Neuroprotective effect of interleukin-6 and IL6/IL6R chimera in the quinolinic acid rat model of Huntington's syndrome

21 January 2018

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Genome-wide analysis of repressor element 1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) target genes

21 January 2018

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The transcriptional repressor REST is a critical regulator of the neurosecretory phenotype

21 January 2018

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The role of REST in transcriptional and epigenetic dysregulation in Huntington's disease

21 January 2018

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Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington's disease.

21 January 2018

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Normal huntingtin function: an alternative approach to Huntington's disease

21 January 2018

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Transcriptional signatures in Huntington's disease

21 January 2018

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Reciprocal actions of REST and a microRNA promote neuronal identity

21 January 2018

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In vivo delivery of DN:REST improves transcriptional changes of REST-regulated genes in HD mice

21 January 2018

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Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

21 January 2018

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Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease

21 January 2018

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Expression of mutant huntingtin blocks exocytosis in PC12 cells by depletion of complexin II

21 January 2018

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Mechanisms of neurodegeneration in Huntington's disease.

21 January 2018

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Synaptotagmins in neurodegeneration

21 January 2018

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Complexin II is essential for normal neurological function in mice.

21 January 2018

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Synaptophysin expression in the striatum in Huntington's disease

21 January 2018

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Regional and cellular gene expression changes in human Huntington's disease brain

21 January 2018

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Human FGF-1 gene delivery protects against quinolinate-induced striatal and hippocampal injury in neonatal rats

21 January 2018

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Amyloid formation by mutant huntingtin: threshold, progressivity and recruitment of normal polyglutamine proteins

21 January 2018

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Gene dysregulation in Huntington's disease: REST, microRNAs and beyond

21 January 2018

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Identification of the REST regulon reveals extensive transposable element-mediated binding site duplication

21 January 2018

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Genome-wide mapping of in vivo protein-DNA interactions

21 January 2018

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REST regulates distinct transcriptional networks in embryonic and neural stem cells

21 January 2018

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A microRNA-based gene dysregulation pathway in Huntington's disease

21 January 2018

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Regulation of neural macroRNAs by the transcriptional repressor REST.

21 January 2018

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Huntingtin interacting proteins are genetic modifiers of neurodegeneration

21 January 2018

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Huntingtin and the molecular pathogenesis of Huntington's disease. Fourth in molecular medicine review series

21 January 2018

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Altered microRNA regulation in Huntington's disease models

21 January 2018

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Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survival

21 January 2018

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Abnormal association of mutant huntingtin with synaptic vesicles inhibits glutamate release

21 January 2018

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Huntington's disease: a synaptopathy?

21 January 2018

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Progressive depletion of complexin II in a transgenic mouse model of Huntington's disease

21 January 2018

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Abnormalities in the synaptic vesicle fusion machinery in Huntington's disease.

21 January 2018

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The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington's disease

21 January 2018

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Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction.

21 January 2018

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microRNA expression in the biology, prognosis, and therapy of Waldenström macroglobulinemia

21 January 2018

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Evidence for more widespread cerebral pathology in early HD: an MRI-based morphometric analysis

21 January 2018

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Regional cortical thinning in preclinical Huntington disease and its relationship to cognition

21 January 2018

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Cerebral cortex and the clinical expression of Huntington's disease: complexity and heterogeneity

21 January 2018

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Huntington's disease: molecular basis of neurodegeneration

21 January 2018

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Silencing is golden: negative regulation in the control of neuronal gene transcription

21 January 2018

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Rescue of gene expression by modified REST decoy oligonucleotides in a cellular model of Huntington's disease

21 January 2018

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The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

21 January 2018

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Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells

21 January 2018

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Aberrant morphology and residual transmitter release at the Munc13-deficient mouse neuromuscular synapse

21 January 2018

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Comparative sequence analysis reveals an intricate network among REST, CREB and miRNA in mediating neuronal gene expression

21 January 2018

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Progressive and selective striatal degeneration in primary neuronal cultures using lentiviral vector coding for a mutant huntingtin fragment

21 January 2018

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Brain-derived neurotrophic factor in neurodegenerative diseases

21 January 2018

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Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes

21 January 2018

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Widespread disruption of repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy at its target genes in Huntington's disease.

21 January 2018

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Structural and functional evolution of the basal ganglia in vertebrates

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/JNC.12090

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11 December 2017

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