Human insulin receptor substrate-1 (IRS-1) polymorphism G972R causes IRS-1 to associate with the insulin receptor and inhibit receptor autophosphorylation (Q45182267)

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scientific article published on 7 December 2004

Language	Label	Description	Also known as
English	Human insulin receptor substrate-1 (IRS-1) polymorphism G972R causes IRS-1 to associate with the insulin receptor and inhibit receptor autophosphorylation	scientific article published on 7 December 2004

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

10 December 2017

Human insulin receptor substrate-1 (IRS-1) polymorphism G972R causes IRS-1 to associate with the insulin receptor and inhibit receptor autophosphorylation (English)

1 reference

Europe PubMed Central

PubMed publication ID

10 December 2017

3

object named as

C Ronald Kahn

1 reference

Europe PubMed Central

PubMed publication ID

10 December 2017

author name string

Aileen J McGettrick

1

1 reference

Europe PubMed Central

PubMed publication ID

10 December 2017

Edward P Feener

2

1 reference

Europe PubMed Central

PubMed publication ID

10 December 2017

language of work or name

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publication date

7 December 2004

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Europe PubMed Central

PubMed publication ID

10 December 2017

number of pages

6

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based on heuristic

inferred from page(s)

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

10 December 2017

280

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Europe PubMed Central

PubMed publication ID

10 December 2017

8

1 reference

Europe PubMed Central

PubMed publication ID

10 December 2017

6441-6446

1 reference

Europe PubMed Central

PubMed publication ID

10 December 2017

Banting Lecture. Insulin action, diabetogenes, and the cause of type II diabetes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412300200

21 January 2018

Aminoacid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412300200

21 January 2018

Gly972Arg variant in the insulin receptor substrate-1 gene and association with Type 2 diabetes: a meta-analysis of 27 studies

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412300200

21 January 2018

The G972R variant of the insulin receptor substrate-1 (IRS-1) gene, body fat distribution and insulin-resistance.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412300200

21 January 2018

Insulin resistance: interactions between obesity and a common variant of insulin receptor substrate-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412300200

21 January 2018

The Gly972Arg polymorphism in the insulin receptor substrate-1 gene contributes to the variation in insulin secretion in normal glucose-tolerant humans

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412300200

21 January 2018

A common mutation of the insulin receptor substrate-1 gene is a risk factor for coronary artery disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412300200

21 January 2018

The Arg972 variant in insulin receptor substrate-1 is associated with an atherogenic profile in offspring of type 2 diabetic patients

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412300200

21 January 2018

Impaired endothelial function in never-treated hypertensive subjects carrying the Arg972 polymorphism in the insulin receptor substrate-1 gene.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412300200

21 January 2018

The Gly972-->Arg IRS-1 variant is associated with type 1 diabetes in continental Italy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412300200

21 January 2018

A functional variant of IRS1 is associated with type 1 diabetes in families from the US and UK.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412300200

21 January 2018

Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412300200

21 January 2018

A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling. Evidence from transfection studies

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412300200

21 January 2018

The Gly-->Arg972 amino acid polymorphism in insulin receptor substrate-1 affects glucose metabolism in skeletal muscle cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412300200

21 January 2018

The Gly972-->Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic beta cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412300200

21 January 2018

The common Arg972 polymorphism in insulin receptor substrate-1 causes apoptosis of human pancreatic islets

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412300200

21 January 2018

Insulin secretory function is impaired in isolated human islets carrying the Gly(972)-->Arg IRS-1 polymorphism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412300200

21 January 2018

G972R IRS-1 variant impairs insulin regulation of endothelial nitric oxide synthase in cultured human endothelial cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412300200

21 January 2018

Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412300200

21 January 2018

The insulin signalling system and the IRS proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412300200

21 January 2018

Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412300200

21 January 2018

Insulin receptor substrate-2 amino acid polymorphisms are not associated with random type 2 diabetes among Caucasians

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412300200

21 January 2018

Search for variants of the gene-promoter and the potential phosphotyrosine encoding sequence of the insulin receptor substrate-2 gene: evaluation of their relation with alterations in insulin secretion and insulin sensitivity.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412300200

21 January 2018

New amino acid substitutions in the IRS-2 gene in Finnish and Chinese subjects with late-onset type 2 diabetes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412300200

21 January 2018

Natural variants of human p85 alpha phosphoinositide 3-kinase in severe insulin resistance: a novel variant with impaired insulin-stimulated lipid kinase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412300200

21 January 2018

Obesity associated with a mutation in a genetic regulator of adipocyte differentiation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412300200

21 January 2018

A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412300200

21 January 2018

Studies of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2) gene in relation to insulin sensitivity among glucose tolerant caucasians

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412300200

21 January 2018

A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412300200

21 January 2018

Defects of the insulin receptor substrate (IRS) system in human metabolic disorders

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412300200

21 January 2018

A novel T608R missense mutation in insulin receptor substrate-1 identified in a subject with type 2 diabetes impairs metabolic insulin signaling.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412300200

21 January 2018

Identifiers

10.1074/JBC.M412300200

1 reference

Europe PubMed Central

PubMed publication ID

10 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

10 December 2017

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