A Rate-Limiting Role for Dickkopf-1 in Bone Formation and the Remediation of Bone Loss in Mouse and Primate Models of Postmenopausal Osteoporosis by an Experimental Therapeutic Antibody (Q45122407)

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scientific article published on April 29, 2011

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English	A Rate-Limiting Role for Dickkopf-1 in Bone Formation and the Remediation of Bone Loss in Mouse and Primate Models of Postmenopausal Osteoporosis by an Experimental Therapeutic Antibody	scientific article published on April 29, 2011

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scholarly article

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Europe PubMed Central

PubMed publication ID

9 December 2017

A rate-limiting role for Dickkopf-1 in bone formation and the remediation of bone loss in mouse and primate models of postmenopausal osteoporosis by an experimental therapeutic antibody (English)

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Europe PubMed Central

PubMed publication ID

9 December 2017

A Rate-Limiting Role for Dickkopf-1 in Bone Formation and the Remediation of Bone Loss in Mouse and Primate Models of Postmenopausal Osteoporosis by an Experimental Therapeutic Antibody (English)

1 reference

10.1124/JPET.111.181404

https://api.crossref.org/works/10.1124/JPET.111.181404

1 December 2024

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inferred from title

postmenopausal osteoporosis

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based on heuristic

inferred from title

animal disease model

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21531794

1 December 2024

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Zhiqiang An

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author name string

Helmut Glantschnig

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Kevin Scott

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Richard Hampton

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9 December 2017

Nan Wei

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Paul McCracken

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9 December 2017

Pascale Nantermet

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9 December 2017

Salvatore Vitelli

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Lingyi Huang

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9 December 2017

Peter Haytko

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9 December 2017

Ping Lu

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Punam Sandhu

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Jacquelynn Cook

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Donald Williams

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William Strohl

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Osvaldo Flores

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9 December 2017

Donald Kimmel

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9 December 2017

Fubao Wang

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9 December 2017

Jing Z. Zhao

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21531794

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John E. Fisher

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1 December 2024

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publication date

29 April 2011

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9 December 2017

number of pages

11

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full work available at URL

https://syndication.highwire.org/content/doi/10.1124/jpet.111.181404

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10.1124/JPET.111.181404

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Journal of Pharmacology and Experimental Therapeutics

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9 December 2017

338

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2

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9 December 2017

568-578

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9 December 2017

Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling

1

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10.1124/JPET.111.181404

https://api.crossref.org/works/10.1124/JPET.111.181404

1 December 2024

IgG2m4, an engineered antibody isotype with reduced Fc function

2

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10.1124/JPET.111.181404

https://api.crossref.org/works/10.1124/JPET.111.181404

1 December 2024

Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow

3

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10.1124/JPET.111.181404

https://api.crossref.org/works/10.1124/JPET.111.181404

1 December 2024

Decreased osteogenesis, increased cell senescence and elevated Dickkopf-1 secretion in human fracture non union stromal cells.

4

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10.1124/JPET.111.181404

https://api.crossref.org/works/10.1124/JPET.111.181404

1 December 2024

Targeting the Wnt/beta-catenin pathway to regulate bone formation in the adult skeleton

5

1 reference

10.1124/JPET.111.181404

https://api.crossref.org/works/10.1124/JPET.111.181404

1 December 2024

Regulation of Wnt/LRP signaling by distinct domains of Dickkopf proteins

6

1 reference

10.1124/JPET.111.181404

https://api.crossref.org/works/10.1124/JPET.111.181404

1 December 2024

High bone density due to a mutation in LDL-receptor-related protein 5

7

1 reference

10.1124/JPET.111.181404

https://api.crossref.org/works/10.1124/JPET.111.181404

1 December 2024

Lrp4, a novel receptor for Dickkopf 1 and sclerostin, is expressed by osteoblasts and regulates bone growth and turnover in vivo

8

1 reference

10.1124/JPET.111.181404

https://api.crossref.org/works/10.1124/JPET.111.181404

1 December 2024

Promising bone-related therapeutic targets for rheumatoid arthritis

9

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10.1124/JPET.111.181404

https://api.crossref.org/works/10.1124/JPET.111.181404

1 December 2024

Future therapeutic targets in osteoporosis

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10.1124/JPET.111.181404

https://api.crossref.org/works/10.1124/JPET.111.181404

1 December 2024

Dickkopf-1 is a master regulator of joint remodeling

11

1 reference

10.1124/JPET.111.181404

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1 December 2024

A review of teriparatide and its clinical efficacy in the treatment of osteoporosis

12

1 reference

10.1124/JPET.111.181404

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1 December 2024

Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity

13

1 reference

10.1124/JPET.111.181404

https://api.crossref.org/works/10.1124/JPET.111.181404

1 December 2024

Expression, purification and functional characterization of Wnt signaling co-receptors LRP5 and LRP6.

14

1 reference

10.1124/JPET.111.181404

https://api.crossref.org/works/10.1124/JPET.111.181404

1 December 2024

Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma

15

1 reference

10.1124/JPET.111.181404

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1 December 2024

Dickkopf-1: a suitable target for the management of myeloma bone disease.

16

1 reference

10.1124/JPET.111.181404

https://api.crossref.org/works/10.1124/JPET.111.181404

1 December 2024

Generation and Selection of Novel Fully Human Monoclonal Antibodies That Neutralize Dickkopf-1 (DKK1) Inhibitory Function in Vitro and Increase Bone Mass in Vivo

17

1 reference

10.1124/JPET.111.181404

https://api.crossref.org/works/10.1124/JPET.111.181404

1 December 2024

LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development

18

1 reference

10.1124/JPET.111.181404

https://api.crossref.org/works/10.1124/JPET.111.181404

1 December 2024

Control of osteoblast function and regulation of bone mass

19

1 reference

10.1124/JPET.111.181404

https://api.crossref.org/works/10.1124/JPET.111.181404

1 December 2024

Inhibiting Dickkopf-1 (Dkk1) removes suppression of bone formation and prevents the development of osteolytic bone disease in multiple myeloma.

20

1 reference

10.1124/JPET.111.181404

https://api.crossref.org/works/10.1124/JPET.111.181404

1 December 2024

Neutralisation of Dkk-1 protects from systemic bone loss during inflammation and reduces sclerostin expression

21

1 reference

10.1124/JPET.111.181404

https://api.crossref.org/works/10.1124/JPET.111.181404

1 December 2024

Serum concentrations of DKK-1 correlate with the extent of bone disease in patients with multiple myeloma.

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1 reference

10.1124/JPET.111.181404

https://api.crossref.org/works/10.1124/JPET.111.181404

1 December 2024

Building bone to reverse osteoporosis and repair fractures

23

1 reference

10.1124/JPET.111.181404

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1 December 2024

Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis

24

1 reference

10.1124/JPET.111.181404

https://api.crossref.org/works/10.1124/JPET.111.181404

1 December 2024

Functional and structural diversity of the human Dickkopf gene family

25

1 reference

10.1124/JPET.111.181404

https://api.crossref.org/works/10.1124/JPET.111.181404

1 December 2024

Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia

26

1 reference

10.1124/JPET.111.181404

https://api.crossref.org/works/10.1124/JPET.111.181404

1 December 2024

A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait

27

1 reference

10.1124/JPET.111.181404

https://api.crossref.org/works/10.1124/JPET.111.181404

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LRP6 mutation in a family with early coronary disease and metabolic risk factors

28

1 reference

10.1124/JPET.111.181404

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Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling

29

1 reference

10.1124/JPET.111.181404

https://api.crossref.org/works/10.1124/JPET.111.181404

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LDL-receptor-related protein 6 is a receptor for Dickkopf proteins

30

1 reference

10.1124/JPET.111.181404

https://api.crossref.org/works/10.1124/JPET.111.181404

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Dickkopf-1 as a potential therapeutic target in Paget's disease of bone

31

1 reference

10.1124/JPET.111.181404

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Vertebral osteoporosis and trabecular bone quality

32

1 reference

10.1124/JPET.111.181404

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Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass

33

1 reference

10.1124/JPET.111.181404

https://api.crossref.org/works/10.1124/JPET.111.181404

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Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee

34

1 reference

10.1124/JPET.111.181404

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The role of Dickkopf-1 in bone development, homeostasis, and disease

35

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Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin

36

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10.1124/JPET.111.181404

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Therapeutic approaches to bone diseases

37

1 reference

10.1124/JPET.111.181404

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SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor

38

1 reference

10.1124/JPET.111.181404

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Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density

39

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10.1124/JPET.111.181404

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Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo

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1 December 2024

Identifiers

10.1124/JPET.111.181404

1 reference

Europe PubMed Central

PubMed publication ID

9 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 December 2017

ResearchGate publication ID

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