Viral-induced spinal motor neuron death is non-cell-autonomous and involves glutamate excitotoxicity. (Q45030474)

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1 January 2020

title

Viral-induced spinal motor neuron death is non-cell-autonomous and involves glutamate excitotoxicity (English)

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1 January 2020

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Jessica Darman

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1 January 2020

Stephanie Backovic

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1 January 2020

Sonny Dike

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1 January 2020

Nicholas J Maragakis

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1 January 2020

Chitra Krishnan

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1 January 2020

Jeffrey D Rothstein

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1 January 2020

David N Irani

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1 January 2020

Douglas A Kerr

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1 January 2020

language of work or name

English

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publication date

1 August 2004

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1 January 2020

published in

Journal of Neuroscience

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volume

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issue

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1 January 2020

page(s)

7566-7575

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Fimbria-fornix transection and excitotoxicity produce similar neurodegeneration in the septum.

1 January 2020

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AMPA exposures induce mitochondrial Ca(2+) overload and ROS generation in spinal motor neurons in vitro.

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Different receptors mediate motor neuron death induced by short and long exposures to excitotoxicity

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Characterization of transient focal ischemia-induced increases in extracellular glutamate and aspartate in spontaneously hypertensive rats

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Antisense knockdown of the glial glutamate transporter GLT-1, but not the neuronal glutamate transporter EAAC1, exacerbates transient focal cerebral ischemia-induced neuronal damage in rat brain.

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Sindbis virus-induced neuronal death is both necrotic and apoptotic and is ameliorated by N-methyl-D-aspartate receptor antagonists

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Protective effect of parvalbumin on excitotoxic motor neuron death.

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An alpha-mercaptoacrylic acid derivative (PD150606) inhibits selective motor neuron death via inhibition of kainate-induced Ca2+ influx and not via calpain inhibition

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Inhibition of glial glutamate transporter GLT-1 augments brain edema after transient focal cerebral ischemia in mice

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Targeting leukocyte MMPs and transmigration: minocycline as a potential therapy for multiple sclerosis

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Minocycline delays disease onset and mortality in a transgenic model of ALS.

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A neuronal glutamate transporter contributes to neurotransmitter GABA synthesis and epilepsy

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Beyond the role of glutamate as a neurotransmitter

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Tardive decrease of astrocytic glutamate transporter protein in transgenic mice with ALS-linked mutant SOD1.

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BCL-2 and BAX protect adult mice from lethal Sindbis virus infection but do not protect spinal cord motor neurons or prevent paralysis

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A poliomyelitis-like syndrome from West Nile virus infection

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Update on the glutamatergic neurotransmitter system and the role of excitotoxicity in amyotrophic lateral sclerosis

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Expression of excitatory amino acid transporter-2 (EAAT-2) and glutamine synthetase (GS) in brain macrophages and microglia of SIVmac251-infected macaques

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The expression of excitatory amino acid transporter 2 in traumatic brain injury.

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Additive neuroprotective effects of minocycline with creatine in a mouse model of ALS.

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Spinal cord disease in West Nile virus infection

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Insights into glutamate transport regulation in human astrocytes: cloning of the promoter for excitatory amino acid transporter 2 (EAAT2).

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Impaired spinal cord glutamate transport capacity and reduced sensitivity to riluzole in a transgenic superoxide dismutase mutant rat model of amyotrophic lateral sclerosis.

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Human embryonic germ cell derivatives facilitate motor recovery of rats with diffuse motor neuron injury.

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Glutamate uptake disguises neurotoxic potency of glutamate agonists in cerebral cortex in dissociated cell culture

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Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis

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Glutamate receptor antagonists protect from virus-induced neural degeneration

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12 December 2020

Conformationally defined neurotransmitter analogs. Selective inhibition of glutamate uptake by one pyrrolidine-2,4-dicarboxylate diastereomer

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12 December 2020

Role of the immune response in Sindbis virus-induced paralysis of SJL/J mice

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12 December 2020

Hundred-fold increase in neuronal vulnerability to glutamate toxicity in astrocyte-poor cultures of rat cerebral cortex

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12 December 2020

The pathogenesis of spinal cord involvement in the encephalomyelitis of mice caused by neuroadapted Sindbis virus infection.

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12 December 2020

Basis of neurovirulence in Sindbis virus encephalomyelitis of mice

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12 December 2020

Inhibition of glutamate uptake with L-trans-pyrrolidine-2,4-dicarboxylate potentiates glutamate toxicity in primary hippocampal cultures

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12 December 2020

Glia modulate the response of murine cortical neurons to excitotoxicity: glia exacerbate AMPA neurotoxicity

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12 December 2020

Regional deafferentation down-regulates subtypes of glutamate transporter proteins

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12 December 2020

Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosis

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12 December 2020

Localization of neuronal and glial glutamate transporters

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12 December 2020

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12 December 2020

Intracerebral cytokine mRNA expression during fatal and nonfatal alphavirus encephalitis suggests a predominant type 2 T cell response

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12 December 2020

Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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Do chemokines mediate leukocyte recruitment in post-traumatic CNS inflammation?

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12 December 2020

10.1523/JNEUROSCI.2002-04.2004

Identifiers

DOI

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1 January 2020

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1 January 2020

PubMed publication ID

15329404

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