An unstructured initiation site is required for efficient proteasome-mediated degradation (Q45018402)

8 December 2017

title

An unstructured initiation site is required for efficient proteasome-mediated degradation (English)

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8 December 2017

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8 December 2017

Sumit Prakash

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Lin Tian

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8 December 2017

Kevin S Ratliff

series ordinal

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8 December 2017

Rebecca E Lehotzky

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8 December 2017

publication date

15 August 2004

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Nature Structural & Molecular Biology

8 December 2017

published in

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8 December 2017

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8 December 2017

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8 December 2017

page(s)

830-837

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The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

8 December 2017

cites work

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Structure of 20S proteasome from yeast at 2.4 A resolution

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A gated channel into the proteasome core particle

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Conformational constraints in protein degradation by the 20S proteasome

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Methotrexate inhibits proteolysis of dihydrofolate reductase by the N-end rule pathway.

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A proteasomal ATPase subunit recognizes the polyubiquitin degradation signal

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The base of the proteasome regulatory particle exhibits chaperone-like activity

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ATP-dependent proteases degrade their substrates by processively unraveling them from the degradation signal

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Linkage between ATP consumption and mechanical unfolding during the protein processing reactions of an AAA+ degradation machine.

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A novel site for ubiquitination: the N-terminal residue, and not internal lysines of MyoD, is essential for conjugation and degradation of the protein.

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Mechanisms underlying ubiquitination

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Recognition of the polyubiquitin proteolytic signal

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Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome

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Context of multiubiquitin chain attachment influences the rate of Sic1 degradation

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ClpAP and ClpXP degrade proteins with tags located in the interior of the primary sequence

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Dislocation of membrane proteins in FtsH-mediated proteolysis

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ClpA mediates directional translocation of substrate proteins into the ClpP protease

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Lack of a robust unfoldase activity confers a unique level of substrate specificity to the universal AAA protease FtsH.

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In vivo half-life of a protein is a function of its amino-terminal residue

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Structural motifs involved in ubiquitin-mediated processing of the NF-kappaB precursor p105: roles of the glycine-rich region and a downstream ubiquitination domain

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Ubiquitin-independent proteolytic functions of the proteasome

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Proteomic discovery of cellular substrates of the ClpXP protease reveals five classes of ClpX-recognition signals

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What does it mean to be natively unfolded?

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Complex interactions between the chaperonin 60 molecular chaperone and dihydrofolate reductase

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The degradation signal in a short-lived protein

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A ubiquitin-based tagging system for controlled modulation of protein stability

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Endoproteolytic activity of the proteasome

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A proteomics approach to understanding protein ubiquitination

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Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination

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Cyclin is degraded by the ubiquitin pathway

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Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation

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Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing.

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Helicase mechanisms and the coupling of helicases within macromolecular machines. Part I: Structures and properties of isolated helicases

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The Escherichia coli DEAD protein DbpA recognizes a small RNA hairpin in 23S rRNA.

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A specificity-enhancing factor for the ClpXP degradation machine

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Distinct peptide signals in the UmuD and UmuD' subunits of UmuD/D' mediate tethering and substrate processing by the ClpXP protease.

31 March 2020

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Proteasome subunit Rpn1 binds ubiquitin-like protein domains

31 March 2020

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Ubiquitylation of BAG-1 suggests a novel regulatory mechanism during the sorting of chaperone substrates to the proteasome

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Recognition of specific ubiquitin conjugates is important for the proteolytic functions of the ubiquitin-associated domain proteins Dsk2 and Rad23.

31 March 2020

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Rad23 ubiquitin-associated domains (UBA) inhibit 26 S proteasome-catalyzed proteolysis by sequestering lysine 48-linked polyubiquitin chains

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The ubiquitin-associated domain of hPLIC-2 interacts with the proteasome

31 March 2020

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The Pfam protein families database

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Involvement of valosin-containing protein, an ATPase Co-purified with IkappaBalpha and 26 S proteasome, in ubiquitin-proteasome-mediated degradation of IkappaBalpha

31 March 2020

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Editing of ubiquitin conjugates by an isopeptidase in the 26S proteasome

31 March 2020

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Multiple associated proteins regulate proteasome structure and function

31 March 2020

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Two-state conformational transition of the extracellular ribonuclease of Bacillus amyloliquefaciens (barnase) induced by sodium dodecyl sulfate

31 March 2020

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Cloning of the Escherichia coli K-12 dihydrofolate reductase gene following mu-mediated transposition.

31 March 2020

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Systematic circular permutation of an entire protein reveals essential folding elements

31 March 2020

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Active unfolding of precursor proteins during mitochondrial protein import

31 March 2020

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Protein translocation channels in the proteasome and other proteases

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NSMB814

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Dimensions Publication ID

8 December 2017

1015293946

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