Phosphorylation of p53 on Thr55 by ERK2 is necessary for doxorubicin-induced p53 activation and cell death (Q44872926)

7 December 2017

title

Phosphorylation of p53 on Thr55 by ERK2 is necessary for doxorubicin-induced p53 activation and cell death (English)

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7 December 2017

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7 December 2017

Kun-Huei Yeh

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Pei Yen Yeh

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7 December 2017

Shuang-En Chuang

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7 December 2017

Ying Chyi Song

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7 December 2017

Lucia Ling-Yuan Chang

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7 December 2017

language of work or name

English

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publication date

1 April 2004

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7 December 2017

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7 December 2017

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7 December 2017

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7 December 2017

page(s)

3580-3588

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Inhibition of extracellular signal-regulated protein kinase or c-Jun N-terminal protein kinase cascade, differentially activated by cisplatin, sensitizes human ovarian cancer cell line

7 December 2017

cites work

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p38 kinase mediates UV-induced phosphorylation of p53 protein at serine 389.

21 January 2018

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p53 is phosphorylated in vitro and in vivo by an ultraviolet radiation-induced protein kinase characteristic of the c-Jun kinase, JNK1.

21 January 2018

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Regulation and function of the p53 tumor suppressor protein

21 January 2018

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ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207426

Analyses of p53 target genes in the human genome by bioinformatic and microarray approaches

21 January 2018

1 reference

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Requirement for ERK activation in cisplatin-induced apoptosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207426

Nuclear extracellular signal-regulated kinase 2 phosphorylates p53 at Thr55 in response to doxorubicin

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207426

Enhanced phosphorylation of p53 by ATM in response to DNA damage

21 January 2018

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7 January 2021

The differential sensitivity of Bc1-2-overexpressing human breast tumor cells to TRAIL or doxorubicin-induced apoptosis is dependent on Bc1-2 protein levels.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207426

7 January 2021

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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7 January 2021

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

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7 January 2021

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

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7 January 2021

p53 mutations in human cancers

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7 January 2021

Apoptosis: a link between cancer genetics and chemotherapy

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7 January 2021

DNA microarrays identification of primary and secondary target genes regulated by p53.

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7 January 2021

p53 is phosphorylated in vitro and in vivo by the delta and epsilon isoforms of casein kinase 1 and enhances the level of casein kinase 1 delta in response to topoisomerase-directed drugs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207426

7 January 2021

Cancer. p53, guardian of the genome

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207426

7 January 2021

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207426

7 January 2021

Mechanisms of switching on p53: a role for covalent modification?

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207426

7 January 2021

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207426

7 January 2021

Effect of extracellular signal-regulated kinase on p53 accumulation in response to cisplatin

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1207426

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Dimensions Publication ID

7 December 2017

1032578111

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