Direct perturbation of lens membrane structure may contribute to cataracts caused by U18666A, an oxidosqualene cyclase inhibitor (Q44854860)

6 December 2017

title

Direct perturbation of lens membrane structure may contribute to cataracts caused by U18666A, an oxidosqualene cyclase inhibitor (English)

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6 December 2017

Richard J Cenedella

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6 December 2017

Robert Jacob

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6 December 2017

Douglas Borchman

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6 December 2017

Daxin Tang

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6 December 2017

Amanda R Neely

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6 December 2017

Abbas Samadi

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6 December 2017

R Preston Mason

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6 December 2017

Patricia Sexton

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6 December 2017

publication date

21 April 2004

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Journal of Lipid Research

6 December 2017

published in

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6 December 2017

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6 December 2017

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6 December 2017

page(s)

1232-1241

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Cholesterol and cataracts

6 December 2017

cites work

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Mechanism of cataract production by 3-β(2-diethylaminoethoxy) androst-5-en-17-one hydrochloride, U18666A: An inhibitor of cholesterol biosynthesis

21 January 2018

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Toxicologic lesions associated with two related inhibitors of oxidosqualene cyclase in the dog and mouse

21 January 2018

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Discordant expression of the sterol pathway in lens underlies simvastatin-induced cataracts in Chbb: Thom rats

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21 January 2018

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21 January 2018

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Apoptotic cell death in the lens epithelium of rat sugar cataract

21 January 2018

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21 January 2018

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21 January 2018

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ABCA1-mediated cholesterol efflux is defective in free cholesterol-loaded macrophages. Mechanism involves enhanced ABCA1 degradation in a process requiring full NPC1 activity

21 January 2018

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Tamoxifen perturbs lipid bilayer order and permeability: comparison of DSC, fluorescence anisotropy, laurdan generalized polarization and carboxyfluorescein leakage studies

21 January 2018

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Studies on the mechanism of the epileptiform activity induced by U18666A. II. Concentration, half-life and distribution of radiolabeled U18666A in the brain

21 January 2018

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Influence of Age, Diabetes, and Cataract on Calcium, Lipid-Calcium, and Protein-Calcium Relationships in Human Lenses

21 January 2018

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Lens epithelial cell apoptosis appears to be a common cellular basis for non-congenital cataract development in humans and animals

21 January 2018

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Cytotoxic cholesterol is generated by the hydrolysis of cytoplasmic cholesteryl ester and transported to the plasma membrane

21 January 2018

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Signalling steps in apoptosis by ether lipids.

21 January 2018

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10.1194/JLR.M300469-JLR200

21 January 2018

Identifiers

DOI

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6 December 2017

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