Alterations in the common fragile site gene Parkin in ovarian and other cancers (Q44653680)

5 December 2017

title

Alterations in the common fragile site gene Parkin in ovarian and other cancers (English)

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5 December 2017

Christine Klein

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5 December 2017

Stacy R Denison

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5 December 2017

Fang Wang

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5 December 2017

Nicole A Becker

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5 December 2017

Birgitt Schüle

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5 December 2017

Norman Kock

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5 December 2017

Leslie A Phillips

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5 December 2017

David I Smith

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5 December 2017

language of work or name

English

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publication date

1 November 2003

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5 December 2017

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5 December 2017

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5 December 2017

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5 December 2017

page(s)

8370-8378

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Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27

5 December 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207072

Immunodetection of Parkin protein in vertebrate and invertebrate brains: a comparative study using specific antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207072

Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207072

Caspase-mediated parkin cleavage in apoptotic cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207072

Two genetic hits (more or less) to cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207072

Association between early-onset Parkinson's disease and mutations in the parkin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207072

Linkage stratification and mutation analysis at the Parkin locus identifies mutation positive Parkinson's disease families

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207072

Restoration of fragile histidine triad (FHIT) expression induces apoptosis and suppresses tumorigenicity in lung and cervical cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207072

Sequence conservation at human and mouse orthologous common fragile regions, FRA3B/FHIT and Fra14A2/Fhit

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207072

Replacement of Fhit in cancer cells suppresses tumorigenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207072

Parkin is linked to the ubiquitin pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207072

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207072

Molecular characterization of FRAXB and comparative common fragile site instability in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207072

7 January 2021

Evidence that instability within the FRA3B region extends four megabases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207072

7 January 2021

Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207072

7 January 2021

Characterization of FRA6E and its potential role in autosomal recessive juvenile parkinsonism and ovarian cancer.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207072

7 January 2021

Parkin: a multipurpose neuroprotective agent?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207072

7 January 2021

Molecular genetic analysis of a novelParkin gene in Japanese families with autosomal recessive juvenile parkinsonism: Evidence for variable homozygous deletions in theParkin gene in affected individuals

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207072

7 January 2021

The importance of gene dosage studies: mutational analysis of the parkin gene in early-onset parkinsonism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207072

7 January 2021

Evaluation of 50 probands with early-onset Parkinson's disease for Parkin mutations

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207072

7 January 2021

A role for common fragile site induction in amplification of human oncogenes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207072

7 January 2021

Molecular findings in familial Parkinson disease in Spain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207072

7 January 2021

The role of the FHIT/FRA3B locus in cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207072

7 January 2021

Parkin is associated with actin filaments in neuronal and nonneural cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207072

7 January 2021

Potential cancer therapy with the fragile histidine triad gene: review of the preclinical studies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207072

7 January 2021

Role of parkin mutations in 111 community-based patients with early-onset parkinsonism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207072

7 January 2021

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207072

7 January 2021

The common fragile site FRA16D and its associated gene WWOX are highly conserved in the mouse at Fra8E1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207072

7 January 2021

The Characterization of the Common Fragile Site FRA16D and Its Involvement in Multiple Myeloma Translocations

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207072

7 January 2021

An FHIT tumor suppressor gene?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207072

7 January 2021

The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207072

7 January 2021

Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207072

7 January 2021

Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207072

7 January 2021

Fragile sites still breaking

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207072

7 January 2021

Complex relationship between Parkin mutations and Parkinson disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207072

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1207072

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Dimensions Publication ID

5 December 2017

1025796748

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1 reference