Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia (Q44536202)

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scientific article published on 3 August 2003

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English	Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia	scientific article published on 3 August 2003

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scholarly article

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3 December 2017

Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia (English)

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3 December 2017

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Takuya Matsunaga

1

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3 December 2017

Naofumi Takemoto

2

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3 December 2017

Tsutomu Sato

3

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3 December 2017

Rishu Takimoto

4

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3 December 2017

Ikuta Tanaka

5

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3 December 2017

Akihito Fujimi

6

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3 December 2017

Takehide Akiyama

7

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3 December 2017

Hiroyuki Kuroda

8

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3 December 2017

Yutaka Kawano

9

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3 December 2017

Masayoshi Kobune

10

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3 December 2017

Junji Kato

11

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3 December 2017

Yasuo Hirayama

12

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3 December 2017

Sumio Sakamaki

13

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3 December 2017

Kyuhei Kohda

14

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3 December 2017

Kensuke Miyake

15

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3 December 2017

Yoshiro Niitsu

16

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3 December 2017

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publication date

3 August 2003

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3 December 2017

Nature Medicine

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3 December 2017

9

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3 December 2017

9

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3 December 2017

1158-1165

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3 December 2017

Randomized study of individualized induction therapy with or without vincristine, and of maintenance-intensification therapy between 4 or 12 courses in adult acute myeloid leukemia. AML-87 Study of the Japan Adult Leukemia Study Group

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Acute myeloid leukemia

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The frequency of long-term remission in patients with acute myelogenous leukaemia treated with conventional maintenance chemotherapy: a study of 760 patients with a minimal follow-up time of 6 years

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Cytogenetic studies of 103 patients with acute myelogenous leukemia in relapse

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Stem cell factor enhances the adhesion of AML cells to fibronectin and augments fibronectin-mediated anti-apoptotic and proliferative signals

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Ligation of the CD44 adhesion molecule reverses blockage of differentiation in human acute myeloid leukemia

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Effects of anti-CD44 monoclonal antibodies on differentiation and apoptosis of human myeloid leukemia cell lines

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Fibronectin interaction with α4β1 integrin prevents apoptosis in B cell chronic lymphocytic leukemia: correlation with Bcl-2 and Bax

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Susceptibility to drug-induced apoptosis correlates with differential modulation of Bad, Bcl-2 and Bcl-xL protein levels

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Integrin signaling inhibits paclitaxel-induced apoptosis in breast cancer cells

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Randomized trials between behenoyl cytarabine and cytarabine in combination induction and consolidation therapy, and with or without ubenimex after maintenance/intensification therapy in adult acute myeloid leukemia. The Japan Leukemia Study Group

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A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

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Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

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Induction of programmed cell death in human hematopoietic cell lines by fibronectin via its interaction with very late antigen 5.

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Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells

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Cross-talk between alpha(4)beta(1)/alpha(5)beta(1) and c-Kit results in opposing effect on growth and survival of hematopoietic cells via the activation of focal adhesion kinase, mitogen-activated protein kinase, and Akt signaling pathways

1 reference

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VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site.

1 reference

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Integrin-mediated survival signals regulate the apoptotic function of Bax through its conformation and subcellular localization.

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Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

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Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation

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7 January 2021

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Integrins induce activation of EGF receptor: role in MAP kinase induction and adhesion-dependent cell survival

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Matrix attachment regulates Fas-induced apoptosis in endothelial cells: a role for c-flip and implications for anoikis

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Requirement for VLA-4 and VLA-5 integrins in lymphoma cells binding to and migration beneath stromal cells in culture

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VLA proteins in the integrin family: structures, functions, and their role on leukocytes

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Identification of putative ligand-binding sites of the integrin alpha 4 beta 1 (VLA-4, CD49d/CD29)

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7 January 2021

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Analysis of fibronectin receptor function with monoclonal antibodies: roles in cell adhesion, migration, matrix assembly, and cytoskeletal organization

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7 January 2021

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Critical amino acid residues for ligand binding are clustered in a predicted beta-turn of the third N-terminal repeat in the integrin alpha 4 and alpha 5 subunits.

1 reference

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3 December 2017

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3 December 2017

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