Prediction of sensitivity to fluoropyrimidines by metabolic and target enzyme activities in gastric cancer (Q44458788)

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scientific article published in January 2003

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English	Prediction of sensitivity to fluoropyrimidines by metabolic and target enzyme activities in gastric cancer	scientific article published in January 2003

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instance of

scholarly article

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Europe PubMed Central

PubMed publication ID

12775024

retrieved

3 December 2017

title

Prediction of sensitivity to fluoropyrimidines by metabolic and target enzyme activities in gastric cancer (English)

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Europe PubMed Central

PubMed publication ID

12775024

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3 December 2017

author name string

Masanori Terashima

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1

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Europe PubMed Central

PubMed publication ID

12775024

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3 December 2017

Hisataka Fujiwara

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2

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Europe PubMed Central

PubMed publication ID

12775024

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3 December 2017

Akinori Takagane

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3

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Europe PubMed Central

PubMed publication ID

12775024

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3 December 2017

Kaoru Abe

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4

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Europe PubMed Central

PubMed publication ID

12775024

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3 December 2017

Takashi Irinoda

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5

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Europe PubMed Central

PubMed publication ID

12775024

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3 December 2017

Tsutomu Nakaya

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6

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Europe PubMed Central

PubMed publication ID

12775024

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3 December 2017

Hitoshi Yonezawa

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7

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Europe PubMed Central

PubMed publication ID

12775024

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3 December 2017

Kenichi Oyama

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8

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Europe PubMed Central

PubMed publication ID

12775024

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3 December 2017

Kazuyoshi Saito

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9

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Europe PubMed Central

PubMed publication ID

12775024

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3 December 2017

Norio Kanzaki

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10

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Europe PubMed Central

PubMed publication ID

12775024

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3 December 2017

Satoshi Ohtani

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11

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Europe PubMed Central

PubMed publication ID

12775024

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3 December 2017

Tsuyoshi Nemoto

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12

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Europe PubMed Central

PubMed publication ID

12775024

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3 December 2017

Yutaka Hoshino

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13

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Europe PubMed Central

PubMed publication ID

12775024

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3 December 2017

Michihiko Kogure

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14

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Europe PubMed Central

PubMed publication ID

12775024

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3 December 2017

Mitsukazu Gotoh

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15

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Europe PubMed Central

PubMed publication ID

12775024

retrieved

3 December 2017

publication date

1 January 2003

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stated in

Europe PubMed Central

PubMed publication ID

12775024

retrieved

3 December 2017

published in

Gastric Cancer

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Europe PubMed Central

PubMed publication ID

12775024

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3 December 2017

volume

6 Suppl 1

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Europe PubMed Central

PubMed publication ID

12775024

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3 December 2017

page(s)

71-81

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Europe PubMed Central

PubMed publication ID

12775024

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3 December 2017

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Thymidine phosphorylase/platelet-derived endothelial cell growth factor expression associated with hepatic metastasis in gastric carcinoma

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21 January 2018

Quantitative measurement of thymidylate synthase and dihydropyrimidine dehydrogenase mRNA level in gastric cancer by real-time RT-PCR.

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Relationship between protein levels and gene expression of dihydropyrimidine dehydrogenase in human tumor cells during growth in culture and in nude mice.

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Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy

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Lack of correlation between thymidylate synthase levels in primary colorectal tumours and subsequent response to chemotherapy

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21 January 2018

Predictive value of thymidylate synthase and dihydropyrimidine dehydrogenase

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Phase II study of UFT plus leucovorin in colorectal cancer

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12 December 2020

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Inhibitory effects of pyrimidine, barbituric acid and pyridine derivatives on 5-fluorouracil degradation in rat liver extracts

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12 December 2020

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Heterogeneity and clinical role of thymidine phosphorylase activity in gastric cancer

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12 December 2020

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A role for dihydropyrimidine dehydrogenase and thymidylate synthase in tumour sensitivity to fluorouracil

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PubMed

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12 December 2020

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Metabolism and mechanism of action of 5-fluorouracil

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12775024

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12 December 2020

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Effect of uracil and its derivatives on antitumor activity of 5-fluorouracil and 1-(2-tetrahydrofuryl)-5-fluorouracil

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https://pubmed.ncbi.nlm.nih.gov/12775024

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12 December 2020

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A multifactorial approach including tumoural epidermal growth factor receptor, p53, thymidylate synthase and dihydropyrimidine dehydrogenase to predict treatment outcome in head and neck cancer patients receiving 5-fluorouracil

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PubMed

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12 December 2020

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Discrepancies between the gene expression, protein expression, and enzymatic activity of thymidylate synthase and dihydropyrimidine dehydrogenase in human gastrointestinal cancers and adjacent normal mucosa.

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12 December 2020

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Thymidylate synthase and drug resistance

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12 December 2020

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Role of thymidine phosphorylase activity in the angiogenic effect of platelet derived endothelial cell growth factor/thymidine phosphorylase.

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12 December 2020

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Thymidylate synthase mRNA level in adenocarcinoma of the stomach: a predictor for primary tumor response and overall survival

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12 December 2020

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Dihydropyrimidine dehydrogenase activity and messenger RNA level may be related to the antitumor effect of 5-fluorouracil on human tumor xenografts in nude mice.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12775024

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12 December 2020

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Roles of thymidylate synthase and dihydropyrimidine dehydrogenase in tumor progression and sensitivity to 5-fluorouracil in human gastric cancer

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12775024

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12 December 2020

based on heuristic

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Dihydropyrimidine dehydrogenase, multidrug resistance-associated protein, and thymidylate synthase gene expression levels can predict 5-fluorouracil resistance in human gastrointestinal cancer cells.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12775024

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12 December 2020

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Clinical application of biochemical modulation in cancer chemotherapy: biochemical modulation for 5-FU

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12 December 2020

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Inhibition by oxonic acid of gastrointestinal toxicity of 5-fluorouracil without loss of its antitumor activity in rats

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12 December 2020

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The usefulness of the ATP assay with serum-free culture for chemosensitivity testing of gastrointestinal cancer

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12775024

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12 December 2020

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Preclinical antitumor efficacy of S-1: a new oral formulation of 5-fluorouracil on human tumor xenografts

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12775024

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of a novel form of an oral 5-fluorouracil derivative (S-1) directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12775024

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Positive correlation between the efficacy of capecitabine and doxifluridine and the ratio of thymidine phosphorylase to dihydropyrimidine dehydrogenase activities in tumors in human cancer xenografts

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12775024

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12 December 2020

based on heuristic

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Antitumor activity of 1 M tegafur-0.4 M 5-chloro-2,4-dihydroxypyridine-1 M potassium oxonate (S-1) against human colon carcinoma orthotopically implanted into nude rats

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PubMed

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12 December 2020

based on heuristic

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The expression of thymidine phosphorylase/platelet-derived endothelial cell growth factor is correlated to angiogenesis in breast cancer

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12775024

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thymidylate synthase (TS) and ribonucleotide reductase (RNR) may be involved in acquired resistance to 5-fluorouracil (5-FU) in human cancer xenografts in vivo

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12775024

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12775024

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Severe neurotoxicity following 5-fluorouracil-based chemotherapy in a patient with dihydropyrimidine dehydrogenase deficiency

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12775024

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12 December 2020

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inferred from PubMed ID database lookup

Japanese Classification of Gastric Carcinoma - 2nd English Edition -

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12775024

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase II study of S-1, a novel oral derivative of 5-fluorouracil, in advanced gastric cancer. For the S-1 Cooperative Gastric Cancer Study Group

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12775024

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of response to 5'-deoxy-5-fluorouridine (5'-DFUR) in patients with inoperable advanced gastric cancer by immunostaining of thymidine phosphorylase/platelet-derived endothelial cell growth factor

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12775024

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo kinetics of thymidylate synthetase inhibition of 5-fluorouracil-sensitive and -resistant murine colon adenocarcinomas.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12775024

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12 December 2020

based on heuristic

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Late phase II study of novel oral fluoropyrimidine anticancer drug S-1 (1 M tegafur-0.4 M gimestat-1 M otastat potassium) in advanced gastric cancer patients

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12775024

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase II study of oral eniluracil, 5-fluorouracil, and leucovorin in patients with advanced colorectal carcinoma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12775024

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Response to fluorouracil therapy in cancer patients: the role of tumoral dihydropyrimidine dehydrogenase activity

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12775024

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infus

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12775024

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetic, oral bioavailability, and safety study of fluorouracil in patients treated with 776C85, an inactivator of dihydropyrimidine dehydrogenase

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12775024

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of uracil on metabolism of 5-fluorouracil in vitro

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12775024

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor angiogenesis and expression of thymidine phosphorylase/platelet derived endothelial cell growth factor in human gastric carcinoma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12775024

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Uracil-ftorafur: an oral fluoropyrimidine active in colorectal cancer

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12775024

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12775024

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dihydropyrimidine dehydrogenase activity in hepatocellular carcinoma: implication in 5-fluorouracil-based chemotherapy

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12775024

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fluorinated pyrimidines, a new class of tumour-inhibitory compounds

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12775024

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preferential activation of capecitabine in tumor following oral administration to colorectal cancer patients

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12775024

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetic study of S-1, a novel oral fluorouracil antitumor drug

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12775024

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinicopathological and prognostic significance of thymidine phosphorylase expression in gastric carcinoma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12775024

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinicopathologic and prognostic significance of an angiogenic factor, thymidine phosphorylase, in human colorectal carcinoma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12775024

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12775024

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fluorinated pyrimidine nucleosides. 3. Synthesis and antitumor activity of a series of 5'-deoxy-5-fluoropyrimidine nucleosides

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12775024

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic value of tumoral thymidylate synthase and p53 in metastatic colorectal cancer patients receiving fluorouracil-based chemotherapy: phenotypic and genotypic analyses.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12775024

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of thymidine phosphorylase and dihydropyrimidine dehydrogenase in tumour progression and sensitivity to doxifluridine in gastric cancer patients

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12775024

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1007/S10120-003-0221-Z

1 reference

stated in

Europe PubMed Central

PubMed publication ID

12775024

retrieved

3 December 2017

PubMed publication ID

12775024

1 reference

stated in

Europe PubMed Central

PubMed publication ID

12775024

retrieved

3 December 2017

ResearchGate publication ID

10735853

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