High pressure liquid chromatography and mass spectrometry characterization of the nephrotoxic biotransformation products of Cisplatin. (Q44447126)

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scientific article published in June 2003

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English	High pressure liquid chromatography and mass spectrometry characterization of the nephrotoxic biotransformation products of Cisplatin.	scientific article published in June 2003

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scholarly article

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Europe PubMed Central

PMC publication ID

6522263

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12756201%20AND%20SRC:MED&resulttype=core&format=json

retrieved

3 November 2019

title

High pressure liquid chromatography and mass spectrometry characterization of the nephrotoxic biotransformation products of Cisplatin (English)

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stated in

Europe PubMed Central

PMC publication ID

6522263

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12756201%20AND%20SRC:MED&resulttype=core&format=json

retrieved

3 November 2019

author name string

Danyelle M Townsend

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1

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Europe PubMed Central

PMC publication ID

6522263

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12756201%20AND%20SRC:MED&resulttype=core&format=json

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3 November 2019

Jarrod A Marto

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2

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Europe PubMed Central

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6522263

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12756201%20AND%20SRC:MED&resulttype=core&format=json

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3 November 2019

Mei Deng

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3

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Europe PubMed Central

PMC publication ID

6522263

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12756201%20AND%20SRC:MED&resulttype=core&format=json

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3 November 2019

Timothy J Macdonald

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4

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Europe PubMed Central

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6522263

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12756201%20AND%20SRC:MED&resulttype=core&format=json

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3 November 2019

Marie H Hanigan

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5

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Europe PubMed Central

PMC publication ID

6522263

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12756201%20AND%20SRC:MED&resulttype=core&format=json

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3 November 2019

publication date

1 June 2003

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Europe PubMed Central

PMC publication ID

6522263

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12756201%20AND%20SRC:MED&resulttype=core&format=json

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3 November 2019

published in

Drug Metabolism and Disposition

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Europe PubMed Central

PMC publication ID

6522263

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12756201%20AND%20SRC:MED&resulttype=core&format=json

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3 November 2019

volume

31

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Europe PubMed Central

PMC publication ID

6522263

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3 November 2019

issue

6

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Europe PubMed Central

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6522263

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12756201%20AND%20SRC:MED&resulttype=core&format=json

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3 November 2019

page(s)

705-713

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Europe PubMed Central

PMC publication ID

6522263

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3 November 2019

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PubMed

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Gamma-glutamyl transpeptidase-deficient mice are resistant to the nephrotoxic effects of cisplatin

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12756201

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12 December 2020

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Inhibition of gamma-glutamyl transpeptidase or cysteine S-conjugate beta-lyase activity blocks the nephrotoxicity of cisplatin in mice

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12756201

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12 December 2020

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Toxic, halogenated cysteine S-conjugates and targeting of mitochondrial enzymes of energy metabolism

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12756201

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12 December 2020

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Metabolism of Cisplatin to a nephrotoxin in proximal tubule cells.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12756201

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12 December 2020

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Nephrotoxicity of the glutathione and cysteine conjugates of 2-bromo-2-chloro-1,1-difluoroethene

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12 December 2020

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Intracellular metabolites of cisplatin in the rat kidney

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12756201

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12 December 2020

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Improved use of buthionine sulfoximine to prevent cisplatin nephrotoxicity in rats

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12 December 2020

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Gamma-glutamyl transpeptidase--its role in hepatocarcinogenesis

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12 December 2020

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Differential effect of cis-platinum (cis-diamminedichloroplatinum) on regulation of liver and kidney haem and haemoprotein metabolism. Possible involvement of gamma-glutamyl-cycle enzymes

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PubMed

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12 December 2020

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Inhibition of cisplatin-induced nephrotoxicity in rats by buthionine sulfoximine, a glutathione synthesis inhibitor

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12756201

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12 December 2020

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Serine-borate complex as a transition-state inhibitor of gamma-glutamyl transpeptidase

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12756201

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12 December 2020

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The role of glutathione conjugate metabolism and cysteine conjugate beta-lyase in the mechanism of S-cysteine conjugate toxicity in LLC-PK1 cells

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12756201

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12 December 2020

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The formation of both a mono- and a bis-substituted glutathione conjugate of hexachlorobutadiene by isolated hepatocytes and following in vivo administration to the rat

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12756201

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cisplatin metabolites in plasma, a study of their pharmacokinetics and importance in the nephrotoxic and antitumour activity of cisplatin

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12756201

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12 December 2020

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inferred from PubMed ID database lookup

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12756201

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12 December 2020

based on heuristic

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In vivo and in vitro nephrotoxicity of the cysteine conjugate of hexachlorobutadiene

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12756201

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12 December 2020

based on heuristic

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Characterization of cisplatin-glutathione adducts by liquid chromatography-mass spectrometry. Evidence for their formation in vitro but not in vivo after concomitant administration of cisplatin and glutathione to rats anc cancer patients

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12756201

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of gamma-glutamyl transpeptidase activity by acivicin in vivo protects the kidney from cisplatin-induced toxicity.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12756201

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12 December 2020

based on heuristic

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Protection against cisplatin-induced nephrotoxicity in the rat by inducers and an inhibitor of glutathione S-transferase

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12756201

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12 December 2020

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Formation and fate of nephrotoxic and cytotoxic glutathione S-conjugates: cysteine conjugate beta-lyase pathway

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12756201

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12 December 2020

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Glutathione-associated cis-diamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells. Molecular characterization of glutathione-platinum complex and its biological significance

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12756201

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cisplatin nephrotoxicity: inhibition of gamma-glutamyl transpeptidase blocks the nephrotoxicity of cisplatin without reducing platinum concentrations in the kidney

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12756201

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic analysis of the cis-diamminedichloroplatinum(II)--cysteine reaction: implications to the extent of platinum--DNA binding.

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12756201

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of cysteine S-conjugate beta-lyases

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12756201

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutathione-dependent bioactivation of haloalkenes

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/12756201

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

gamma-Glutamyl transpeptidase, a glutathionase: its expression and function in carcinogenesis

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/12756201

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1124/DMD.31.6.705

1 reference

stated in

Europe PubMed Central

PMC publication ID

6522263

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12756201%20AND%20SRC:MED&resulttype=core&format=json

retrieved

3 November 2019

PMC publication ID

6522263

1 reference

stated in

Europe PubMed Central

PMC publication ID

6522263

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12756201%20AND%20SRC:MED&resulttype=core&format=json

retrieved

3 November 2019

PubMed publication ID

12756201

1 reference

stated in

Europe PubMed Central

PMC publication ID

6522263

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12756201%20AND%20SRC:MED&resulttype=core&format=json

retrieved

3 November 2019

ResearchGate publication ID

10752369

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