Total loss of MHC class I in colorectal tumors can be explained by two molecular pathways: β2‐microglobulin inactivation in MSI‐positive tumors and LMP7/TAP2 downregulation in MSI‐negative tumors (Q44402973)

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scientific article published on March 1, 2003

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English	Total loss of MHC class I in colorectal tumors can be explained by two molecular pathways: β2‐microglobulin inactivation in MSI‐positive tumors and LMP7/TAP2 downregulation in MSI‐negative tumors	scientific article published on March 1, 2003

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scholarly article

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Europe PubMed Central

PubMed publication ID

2 December 2017

Total loss of MHC class I in colorectal tumors can be explained by two molecular pathways: beta2-microglobulin inactivation in MSI-positive tumors and LMP7/TAP2 downregulation in MSI-negative tumors (English)

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

Total loss of MHC class I in colorectal tumors can be explained by two molecular pathways: β2‐microglobulin inactivation in MSI‐positive tumors and LMP7/TAP2 downregulation in MSI‐negative tumors (English)

1 reference

10.1034/J.1399-0039.2003.00020.X

https://api.crossref.org/works/10.1034/J.1399-0039.2003.00020.X

24 December 2023

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10.1034/J.1399-0039.2003.00020.X

https://api.crossref.org/works/10.1034/J.1399-0039.2003.00020.X

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10.1034/J.1399-0039.2003.00020.X

https://api.crossref.org/works/10.1034/J.1399-0039.2003.00020.X

24 December 2023

1 reference

10.1034/J.1399-0039.2003.00020.X

https://api.crossref.org/works/10.1034/J.1399-0039.2003.00020.X

24 December 2023

Francisco Ruiz-Cabello

5

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F. Ruiz-Cabello

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24 December 2023

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C. M. Cabrera

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24 December 2023

P. Jiménez

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24 December 2023

T. Cabrera

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24 December 2023

C. Esparza

4

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24 December 2023

F. Garrido

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24 December 2023

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24 December 2023

publication date

1 March 2003

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2 December 2017

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https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1034%2Fj.1399-0039.2003.00020.x

1 reference

10.1034/J.1399-0039.2003.00020.X

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24 December 2023

https://onlinelibrary.wiley.com/doi/pdf/10.1034/j.1399-0039.2003.00020.x

1 reference

10.1034/J.1399-0039.2003.00020.X

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24 December 2023

Tissue Antigens

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Europe PubMed Central

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2 December 2017

61

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2 December 2017

3

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2 December 2017

211-219

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Europe PubMed Central

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2 December 2017

Implications for immunosurveillance of altered HLA class I phenotypes in human tumours

1 reference

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Natural history of HLA expression during tumour development.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0039.2003.00020.X

21 January 2018

Extensive characterization of genetic alterations in a series of human colorectal cancer cell lines.

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https://api.crossref.org/works/10.1034%2FJ.1399-0039.2003.00020.X

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Induction of immunogenicity of a human renal-cell carcinoma cell line by TAP1-gene transfer

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A new beta 2 microglobulin mutation found in a melanoma tumor cell line

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Gastrointestinal cancer of the microsatellite mutator phenotype pathway

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Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype.

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Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

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Visualization of the ER-to-cytosol dislocation reaction of a type I membrane protein

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Misfolded major histocompatibility complex class I heavy chains are translocated into the cytoplasm and degraded by the proteasome

1 reference

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Expression of HLA class II in colorectal cancer: evidence for enhanced immunogenicity of microsatellite-instability-positive tumours

1 reference

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21 January 2018

Escape from host-antitumor immunity.

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MHC class I-deficient metastatic tumor variants immunoselected by T lymphocytes originate from the coordinated downregulation of APM components.

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Investigation of HLA class I downregulation in breast cancer by RT-PCR

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Markedly decreased expression of TAP1 and LMP2 genes in HLA class I-deficient human tumor cell lines

1 reference

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7 January 2021

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Lack of HLA-class I antigens in human neuroblastoma cells: analysis of its relationship to TAP and tapasin expression

1 reference

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MHC antigens and tumor escape from immune surveillance

1 reference

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Analysis of HLA expression in human tumor tissues

1 reference

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Mutations of the beta2-microglobulin gene result in a lack of HLA class I molecules on melanoma cells of two patients immunized with MAGE peptides

1 reference

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High frequency of altered HLA class I phenotypes in invasive colorectal carcinomas

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Microsatellite instability in colorectal-cancer patients with suspected genetic predisposition

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Selection for beta 2-microglobulin mutation in mismatch repair-defective colorectal carcinomas.

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Criteria to define HLA haplotype loss in human solid tumors

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Molecular strategies to define HLA haplotype loss in microdissected tumor cells

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MHC class I expression in mice lacking the proteasome subunit LMP-7

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The nature of the MHC class I peptide loading complex

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Assembly of ER-associated protein degradation in vitro: dependence on cytosol, calnexin, and ATP.

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Gastric cancers of the microsatellite mutator phenotype display characteristic genetic and clinical features

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Somatic mutation of the β2-microglobulin gene associates with unfavorable prognosis in gastrointestinal cancer of the microsatellite mutator phenotype

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Microsatellite instability is a favorable prognostic indicator in patients with colorectal cancer receiving chemotherapy

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Impaired surface antigen presentation in tumors: implications for T cell-based immunotherapy.

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Somatic frameshift mutations in DNA mismatch repair and proapoptosis genes in hereditary nonpolyposis colorectal cancer

35

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10.1034/J.1399-0039.2003.00020.X

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Identifiers

10.1034/J.1399-0039.2003.00020.X

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

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