Structure-based engineering of a monoclonal antibody for improved solubility (Q44381771)

2 December 2017

title

Structure-based engineering of a monoclonal antibody for improved solubility (English)

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2 December 2017

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2 December 2017

Sheng-Jiun Wu

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2 December 2017

Jinquan Luo

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2 December 2017

Karyn T O'Neil

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2 December 2017

James Kang

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2 December 2017

Eilyn R Lacy

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2 December 2017

Gabriela Canziani

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2 December 2017

Audrey Baker

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2 December 2017

Maggie Huang

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2 December 2017

Qing Mike Tang

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2 December 2017

T Shantha Raju

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2 December 2017

Steven A Jacobs

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2 December 2017

Gary L Gilliland

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2 December 2017

Yiqing Feng

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2 December 2017

publication date

11 June 2010

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Protein Engineering Design and Selection

2 December 2017

published in

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2 December 2017

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2 December 2017

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2 December 2017

page(s)

643-651

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Correlation for the partition behavior of proteins in aqueous two-phase systems: effect of surface hydrophobicity and charge

2 December 2017

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Structural characterization of N-linked oligosaccharides on monoclonal antibody cetuximab by the combination of orthogonal matrix-assisted laser desorption/ionization hybrid quadrupole-quadrupole time-of-flight tandem mass spectrometry and sequentia

21 January 2018

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Terminal sugars of Fc glycans influence antibody effector functions of IgGs

21 January 2018

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Fc glycans terminated with N-acetylglucosamine residues increase antibody resistance to papain

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Incremental window-based protein sequence alignment algorithms

21 January 2018

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The human combinatorial antibody library HuCAL GOLD combines diversification of all six CDRs according to the natural immune system with a novel display method for efficient selection of high-affinity antibodies.

21 January 2018

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Oligosaccharide analysis and molecular modeling of soluble forms of glycoproteins belonging to the Ly-6, scavenger receptor, and immunoglobulin superfamilies expressed in Chinese hamster ovary cells.

21 January 2018

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Higher levels of sialylated Fc glycans in immunoglobulin G molecules can adversely impact functionality

21 January 2018

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High-resolution crystal structure of M-protease: phylogeny aided analysis of the high-alkaline adaptation mechanism

21 January 2018

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21 January 2018

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Expression and characterization of a human BMP-7 variant with improved biochemical properties

21 January 2018

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Engineering the isoelectric point of a renal cell carcinoma targeting antibody greatly enhances scFv solubility

21 January 2018

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21 January 2018

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Amino acid contribution to protein solubility: Asp, Glu, and Ser contribute more favorably than the other hydrophilic amino acids in RNase Sa.

21 January 2018

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Membrane separations in biotechnology

21 January 2018

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The impact of PEGylation on biological therapies

21 January 2018

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Glycosylation of a VH residue of a monoclonal antibody against alpha (1----6) dextran increases its affinity for antigen

21 January 2018

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21 January 2018

Identifiers

DOI

10.1093/PROTEIN/GZQ037

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2 December 2017

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