The Human RecQ helicases, BLM and RECQ1, display distinct DNA substrate specificities. (Q44302296)

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6 January 2020

title

The Human RecQ helicases, BLM and RECQ1, display distinct DNA substrate specificities (English)

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6 January 2020

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6 January 2020

Venkateswarlu Popuri

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6 January 2020

Laura Muzzolini

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6 January 2020

Georgina Mosedale

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6 January 2020

Silvia Costantini

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6 January 2020

Elisa Giacomini

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6 January 2020

Ian D Hickson

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Alessandro Vindigni

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6 January 2020

language of work or name

English

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publication date

30 April 2008

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Journal of Biological Chemistry

6 January 2020

published in

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volume

283

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issue

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page(s)

17766-17776

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The recQ gene of Escherichia coli K12: molecular cloning and isolation of insertion mutants

6 January 2020

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RecQ helicases: caretakers of the genome

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DNA helicases required for homologous recombination and repair of damaged replication forks

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Junction of RecQ helicase biochemistry and human disease.

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The Bloom's syndrome gene product is homologous to RecQ helicases

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Rothmund-thomson syndrome responsible gene, RECQL4: genomic structure and products

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Single nucleotide polymorphisms of RecQ1, RAD54L, and ATM genes are associated with reduced survival of pancreatic cancer

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Significant effect of homologous recombination DNA repair gene polymorphisms on pancreatic cancer survival

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The Bloom's syndrome helicase promotes the annealing of complementary single-stranded DNA

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Human RECQ5beta, a protein with DNA helicase and strand-annealing activities in a single polypeptide

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RecQ family members combine strand pairing and unwinding activities to catalyze strand exchange

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Biochemical characterization of the RECQ4 protein, mutated in Rothmund-Thomson syndrome

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Biochemical analysis of the DNA unwinding and strand annealing activities catalyzed by human RECQ1.

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The premature ageing syndrome protein, WRN, is a 3'-->5' exonuclease

21 January 2018

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Werner syndrome protein. I. DNA helicase and dna exonuclease reside on the same polypeptide.

21 January 2018

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Werner syndrome helicase contains a 5'-->3' exonuclease activity that digests DNA and RNA strands in DNA/DNA and RNA/DNA duplexes dependent on unwinding

21 January 2018

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Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest

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The Bloom's syndrome gene product promotes branch migration of holliday junctions

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The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases

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The Saccharomyces cerevisiae Sgs1 helicase efficiently unwinds G-G paired DNAs

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Substrate-specific inhibition of RecQ helicase

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RecQ helicases: suppressors of tumorigenesis and premature aging.

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Analysis of the unwinding activity of the dimeric RECQ1 helicase in the presence of human replication protein A

21 January 2018

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Oligomeric ring structure of the Bloom's syndrome helicase

21 January 2018

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Characterization and mutational analysis of the RecQ core of the bloom syndrome protein

21 January 2018

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Mobile D-loops are a preferred substrate for the Bloom's syndrome helicase.

21 January 2018

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Preclinical and clinical progress of particle-mediated DNA vaccines for infectious diseases

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The Bloom's syndrome helicase can promote the regression of a model replication fork.

21 January 2018

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Different quaternary structures of human RECQ1 are associated with its dual enzymatic activity

21 January 2018

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G4 DNA unwinding by BLM and Sgs1p: substrate specificity and substrate-specific inhibition

21 January 2018

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Effects of RNA polymerase modifications on transcription-induced negative supercoiling and associated R-loop formation

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21 January 2018

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Cotranscriptionally Formed DNA:RNA Hybrids Mediate Transcription Elongation Impairment and Transcription-Associated Recombination

21 January 2018

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DNA topoisomerases regulate R-loop formation during transcription of the rrnB operon in Escherichia coli.

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The replicative helicases of bacteria, archaea, and eukarya can unwind RNA-DNA hybrid substrates.

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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The HRDC domain of BLM is required for the dissolution of double Holliday junctions

21 January 2018

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Human RECQ1 is a DNA damage responsive protein required for genotoxic stress resistance and suppression of sister chromatid exchanges

21 January 2018

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BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates

21 January 2018

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RECQL, a member of the RecQ family of DNA helicases, suppresses chromosomal instability.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M709749200

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18448429%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

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