The role of the nuclear receptor CAR as a coordinate regulator of hepatic gene expression in defense against chemical toxicity. (Q44237370)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12464260%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

title

The role of the nuclear receptor CAR as a coordinate regulator of hepatic gene expression in defense against chemical toxicity (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12464260%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12464260%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12464260%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

Masahiko Negishi

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12464260%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

language of work or name

English

0 references

publication date

1 January 2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12464260%20AND%20SRC:MED&resulttype=core&format=json

Archives of Biochemistry and Biophysics

15 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12464260%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

volume

409

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12464260%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

issue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12464260%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

page(s)

207-211

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12464260%20AND%20SRC:MED&resulttype=core&format=json

Phenobarbital induction of cytochrome P-450 gene expression

15 December 2019

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900456-3

Regulatory DNA elements of phenobarbital-responsive cytochrome P450 CYP2B genes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900456-3

Phenobarbital response elements of cytochrome P450 genes and nuclear receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900456-3

The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900456-3

Activation by diverse xenochemicals of the 51-base pair phenobarbital-responsive enhancer module in the CYP2B10 gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900456-3

The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900456-3

Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900456-3

Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900456-3

Nuclear receptor regulation of hepatic function

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900456-3

Aldehyde dehydrogenase gene superfamily: the 2000 update.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900456-3

Structure and function of sulfotransferases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900456-3

Effect of Antiepileptic drugs on plasma lipoprotein (a) and other lipid levels in childhood

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900456-3

Orphan nuclear receptors as eLiXiRs and FiXeRs of sterol metabolism.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900456-3

Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900456-3

Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900456-3

Nuclear orphan receptors control cholesterol catabolism.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900456-3

Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900456-3

An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900456-3

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900456-3

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900456-3

Glucocorticoid and sex hormones as activating or modulating factors for expression of Cyp2b-9 and Cyp2b-10 in the mouse liver and hepatocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900456-3

Estrogen-Induced Cholestasis: Clues to Pathogenesis and Treatment

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900456-3

The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900456-3

Enhancement of glucuronide-conjugating capacity in a hyperbilirubinemic infant due to apparent enzyme induction by phenobarbital

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900456-3

Identification of a defect in the UGT1A1 gene promoter and its association with hyperbilirubinemia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900456-3

Organ distribution of multidrug resistance proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and hepatic induction of Mrp3 by constitutive androstane receptor activators in rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900456-3

Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900456-3

Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900456-3

Structural flexibility and functional versatility of mammalian P450 enzymes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900456-3

The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900456-3

Residue threonine 350 confers steroid hormone responsiveness to the mouse nuclear orphan receptor CAR.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900456-3

Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900456-3

The peptide near the C terminus regulates receptor CAR nuclear translocation induced by xenochemicals in mouse liver

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900456-3

Protein serine/threonine phosphatase inhibitors suppress phenobarbital-induced Cyp2b10 gene transcription in mouse primary hepatocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900456-3

10.1016/S0003-9861(02)00456-3

7 January 2021

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12464260%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12464260%20AND%20SRC:MED&resulttype=core&format=json