Substrate selectivity of human cytochrome P450 2C9: importance of residues 476, 365, and 114 in recognition of diclofenac and sulfaphenazole and in mechanism-based inactivation by tienilic acid (Q44237349)

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scientific article published in January 2003

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English	Substrate selectivity of human cytochrome P450 2C9: importance of residues 476, 365, and 114 in recognition of diclofenac and sulfaphenazole and in mechanism-based inactivation by tienilic acid	scientific article published in January 2003

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scholarly article

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1 December 2017

Substrate selectivity of human cytochrome P450 2C9: importance of residues 476, 365, and 114 in recognition of diclofenac and sulfaphenazole and in mechanism-based inactivation by tienilic acid (English)

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1 December 2017

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Nadine Assrir

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Armelle Melet

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Pascale Jean

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1 December 2017

Maria Pilar Lopez-Garcia

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1 December 2017

Cristina Marques-Soares

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1 December 2017

Maryse Jaouen

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1 December 2017

Patrick M Dansette

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1 December 2017

Marie Agnès Sari

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Daniel Mansuy

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1 December 2017

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1 January 2003

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Archives of Biochemistry and Biophysics

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1 December 2017

409

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1 December 2017

1

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1 December 2017

80-91

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1 December 2017

Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 (S)-mephenytoin 4'-hydroxylase

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Cytochrome P4502C9: an enzyme of major importance in human drug metabolism

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Diclofenac and Its Derivatives As Tools for Studying Human Cytochromes P450 Active Sites: Particular Efficiency and Regioselectivity of P450 2Cs

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The Substrate Binding Site of Human Liver Cytochrome P450 2C9: An Approach Using Designed Tienilic Acid Derivatives and Molecular Modeling

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The Substrate Binding Site of Human Liver Cytochrome P450 2C9: An NMR Study†

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Structural forms of phenprocoumon and warfarin that are metabolized at the active site of CYP2C9.

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Enzymatic determinants of the substrate specificity of CYP2C9: role of B'-C loop residues in providing the pi-stacking anchor site for warfarin binding

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Arginines 97 and 108 in CYP2C9 are important determinants of the catalytic function

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Thiophene derivatives as new mechanism-based inhibitors of cytochromes P-450: inactivation of yeast-expressed human liver cytochrome P-450 2C9 by tienilic acid

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Synthesis of sulfaphenazole derivatives and their use as inhibitors and tools for comparing the active sites of human liver cytochromes P450 of the 2C subfamily.

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10.1016/S0003-9861(02)00548-9

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Europe PubMed Central

PubMed publication ID

1 December 2017

PubMed publication ID

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Europe PubMed Central

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1 December 2017

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