Treadmill exercise represses neuronal cell death and inflammation during Aβ-induced ER stress by regulating unfolded protein response in aged presenilin 2 mutant mice (Q44157472)

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scientific article published in November 2013

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English	Treadmill exercise represses neuronal cell death and inflammation during Aβ-induced ER stress by regulating unfolded protein response in aged presenilin 2 mutant mice	scientific article published in November 2013

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scholarly article

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Europe PubMed Central

PubMed publication ID

30 November 2017

Treadmill exercise represses neuronal cell death and inflammation during Aβ-induced ER stress by regulating unfolded protein response in aged presenilin 2 mutant mice (English)

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Europe PubMed Central

PubMed publication ID

30 November 2017

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Eun-Bum Kang

1

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Europe PubMed Central

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30 November 2017

In-Su Kwon

2

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30 November 2017

Jung-Hoon Koo

3

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30 November 2017

Eung-Joon Kim

4

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30 November 2017

Chul-Hyun Kim

5

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30 November 2017

Jin Lee

6

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30 November 2017

Choon-Ho Yang

7

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30 November 2017

Young-Il Lee

8

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30 November 2017

In-Ho Cho

9

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30 November 2017

Joon-Yong Cho

10

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30 November 2017

publication date

1 November 2013

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30 November 2017

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30 November 2017

18

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30 November 2017

11

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Europe PubMed Central

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30 November 2017

1332-1347

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Europe PubMed Central

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30 November 2017

Endoplasmic reticulum stress: signaling the unfolded protein response

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

The endoplasmic reticulum and the unfolded protein response

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Intracellular amyloid-beta in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

ER stress and neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Endoplasmic reticulum protein quality control in neurodegenerative disease: the good, the bad and the therapy

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Intracellular signaling by the unfolded protein response

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

ER stress and the unfolded protein response

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Protein disulfide isomerase regulates endoplasmic reticulum stress and the apoptotic process during prion infection and PrP mutant-induced cytotoxicity

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

A trip to the ER: coping with stress

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

The unfolded protein response is activated in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

The unfolded protein response is activated in pretangle neurons in Alzheimer's disease hippocampus

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Endoplasmic reticulum (ER) chaperone regulation and survival of cells compensating for deficiency in the ER stress response kinase, PERK

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Physiology and pathophysiology of the calcium store in the endoplasmic reticulum of neurons

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression.

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Characterization of plasma β-secretase (BACE1) activity and soluble amyloid precursor proteins as potential biomarkers for Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Alzheimer disease: mouse models pave the way for therapeutic opportunities

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Inflammation and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Induction of neuronal death by ER stress in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Neuronal and glial calcium signaling in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Up-regulation of the inflammatory cytokines IFN-gamma and IL-12 and down-regulation of IL-4 in cerebral cortex regions of APP(SWE) transgenic mice

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

The stress rheostat: an interplay between the unfolded protein response (UPR) and autophagy in neurodegeneration

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Inflammation in Alzheimer's disease: amyloid-beta oligomers trigger innate immunity defence via pattern recognition receptors

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Endoplasmic reticulum stress and the inflammatory basis of metabolic disease

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Use of NSE/PS2m-transgenic mice in the study of the protective effect of exercise on Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Exercise: a behavioral intervention to enhance brain health and plasticity

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

An active and socially integrated lifestyle in late life might protect against dementia

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Pen2 and presenilin-1 modulate the dynamic equilibrium of presenilin-1 and presenilin-2 gamma-secretase complexes

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Mutant presenilin 2 increases acetylcholinesterase activity in neuronal cells

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Mutant presenilin 2 causes abnormality in the brain lipid profile in the development of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Alterations in behavior, amyloid beta-42, caspase-3, and Cox-2 in mutant PS2 transgenic mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Regular exercise produced cardioprotective effects on rat's heart with hypertension induced by L-NAME administration.

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Mutant presenilin 2 increased oxidative stress and p53 expression in neuronal cells

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Impairment of the ubiquitin-proteasome system by protein aggregation

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Adult neuron survival strategies--slamming on the brakes

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Protein misfolding in Alzheimer's and Parkinson's disease: genetics and molecular mechanisms

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Endoplasmic reticulum stress response and neurodegeneration

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Unfolding the role of protein misfolding in neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Endoplasmic reticulum enrollment in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Unconventional splicing of XBP-1 mRNA in the unfolded protein response

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Exercise is more effective than diet control in preventing high fat diet-induced β-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Melatonin plus physical exercise are highly neuroprotective in the 3xTg-AD mouse

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

The endoplasmic reticulum stress-responsive protein GRP78 protects neurons against excitotoxicity and apoptosis: suppression of oxidative stress and stabilization of calcium homeostasis

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity.

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Abeta 1-42 induces mild endoplasmic reticulum stress in an aggregation state-dependent manner.

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Endoplasmic reticulum stress in disease: mechanisms and therapeutic opportunities

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Mediators of endoplasmic reticulum stress-induced apoptosis

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153).

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Reduced eIF2alpha phosphorylation and increased proapoptotic proteins in aging

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

ER stress is involved in Abeta-induced GSK-3beta activation and tau phosphorylation

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Viral control of mitochondrial apoptosis

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

beta-Amyloid and endoplasmic reticulum stress responses in primary neurons: effects of drugs that interact with the cytoskeleton.

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

In situ immunodetection of neuronal caspase-3 activation in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Presenilin-1 mutation activates the signaling pathway of caspase-4 in endoplasmic reticulum stress-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Activation of the Akt-NF-kappaB pathway by subtilase cytotoxin through the ATF6 branch of the unfolded protein response

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

HIV protease inhibitor lopinavir-induced TNF-alpha and IL-6 expression is coupled to the unfolded protein response and ERK signaling pathways in macrophages

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Tumor necrosis factor-α synthesis inhibitor 3,6'-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

Exercise induces autophagy in peripheral tissues and in the brain

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0884-9

21 January 2018

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10.1007/S10495-013-0884-9

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Europe PubMed Central

PubMed publication ID

30 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 November 2017

ResearchGate publication ID

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