Pathway-specific tumor suppression. Reduction of p27 accelerates gastrointestinal tumorigenesis in Apc mutant mice, but not in Smad3 mutant mice (Q44043140)

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scientific article published in May 2002

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English	Pathway-specific tumor suppression. Reduction of p27 accelerates gastrointestinal tumorigenesis in Apc mutant mice, but not in Smad3 mutant mice	scientific article published in May 2002

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

Pathway-specific tumor suppression. Reduction of p27 accelerates gastrointestinal tumorigenesis in Apc mutant mice, but not in Smad3 mutant mice (English)

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

author name string

Jeannette Philipp-Staheli

1

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

Kyung-Hoon Kim

2

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

Shannon R Payne

3

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

Kay E Gurley

4

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

Denny Liggitt

5

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

Gary Longton

6

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

Christopher J Kemp

7

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

publication date

1 May 2002

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

4

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

355-368

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

Are animal models of colon cancer relevant to human disease.

1 reference

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Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response

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7 January 2021

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Key role of the cyclin-dependent kinase inhibitor p27kip1 for embryonal carcinoma cell survival and differentiation.

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beta-Catenin mutation in rat colon tumors initiated by 1,2-dimethylhydrazine and 2-amino-3-methylimidazo[4,5-f]quinoline, and the effect of post-initiation treatment with chlorophyllin and indole-3-carbinol

1 reference

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7 January 2021

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SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

1 reference

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7 January 2021

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Oligodendrocyte precursor differentiation is perturbed in the absence of the cyclin-dependent kinase inhibitor p27Kip1.

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Decreased levels of the cell-cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancer

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Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction

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STAT3-mediated differentiation and survival and of myeloid cells in response to granulocyte colony-stimulating factor: role for the cyclin-dependent kinase inhibitor p27(Kip1)

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Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse

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Dependence of cyclin E-CDK2 kinase activity on cell anchorage.

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A genetic model for colorectal tumorigenesis

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A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

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The murine gene p27Kip1 is haplo-insufficient for tumour suppression

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Mutations in the APC tumour suppressor gene cause chromosomal instability

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Identification and characterization of the familial adenomatous polyposis coli gene

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p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

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Ovarian cancer has frequent loss of heterozygosity at chromosome 12p12.3-13.1 (region of TEL and Kip1 loci) and chromosome 12q23-ter: evidence for two new tumour-suppressor genes

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Identification of c-MYC as a target of the APC pathway

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7 January 2021

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Mutations in the K-ras oncogene induced by 1,2-dimethylhydrazine in preneoplastic and neoplastic rat colonic mucosa

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A role for the Adenomatous Polyposis Coli protein in chromosome segregation

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Reduced expression of the cell-cycle inhibitor p27Kip1 is associated with progression and lymph node metastasis of gastric carcinoma

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7 January 2021

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Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).

1 reference

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p27 is involved in N-cadherin-mediated contact inhibition of cell growth and S-phase entry

1 reference

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p27kip1: a multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers

1 reference

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Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.

1 reference

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Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

1 reference

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TGF-beta signal transduction

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Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis

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p27 expression and gastric carcinoma

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Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

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p27(Kip1): regulation and function of a haploinsufficient tumor suppressor and its misregulation in cancer.

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Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

1 reference

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1 reference

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Going mad with Smads

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Smad3 mutant mice develop metastatic colorectal cancer

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10.1016/S1535-6108(02)00054-5

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

ResearchGate publication ID

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