BCR/ABL P190 transgenic mice develop leukemia in the absence of Crkl (Q44040285)

29 November 2017

title

BCR/ABL P190 transgenic mice develop leukemia in the absence of Crkl (English)

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29 November 2017

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Bianca Hemmeryckx

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Nora Heisterkamp

object named as

Nora Heisterkamp

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29 November 2017

Anja Reichert

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29 November 2017

Meguru Watanabe

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29 November 2017

Vesa Kaartinen

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29 November 2017

Ron de Jong

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29 November 2017

Paul K Pattengale

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29 November 2017

John Groffen

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29 November 2017

language of work or name

English

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publication date

1 May 2002

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29 November 2017

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29 November 2017

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29 November 2017

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29 November 2017

page(s)

3225-3231

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Tyrosine 207 in CRKL is the BCR/ABL phosphorylation site

29 November 2017

cites work

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p62(dok), a negative regulator of Ras and mitogen-activated protein kinase (MAPK) activity, opposes leukemogenesis by p210(bcr-abl)

21 January 2018

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Physiological signals and oncogenesis mediated through Crk family adapter proteins

21 January 2018

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Crk family adaptors-signalling complex formation and biological roles

21 January 2018

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Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

21 January 2018

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Mice lacking the homologue of the human 22q11.2 gene CRKL phenocopy neurocristopathies of DiGeorge syndrome

21 January 2018

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Acute leukaemia in bcr/abl transgenic mice

21 January 2018

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Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction

21 January 2018

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Chronic myelogenous leukemia blast cell proliferation is inhibited by peptides that disrupt Grb2-SoS complexes

21 January 2018

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Cell-penetrating SH3 domain blocker peptides inhibit proliferation of primary blast cells from CML patients

21 January 2018

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CRKL binding to BCR-ABL and BCR-ABL transformation

21 January 2018

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Tyrosine phosphorylation of Grb2 by Bcr/Abl and epidermal growth factor receptor: a novel regulatory mechanism for tyrosine kinase signaling

21 January 2018

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Interleukin 3 and granulocyte-macrophage colony-stimulating factor are not required for induction of chronic myeloid leukemia-like myeloproliferative disease in mice by BCR/ABL.

21 January 2018

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Two species of human CRK cDNA encode proteins with distinct biological activities

21 January 2018

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Role of the adapter protein CRKL in signal transduction of normal hematopoietic and BCR/ABL-transformed cells

21 January 2018

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21 January 2018

Chronic myeloid leukemia

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The CRKL adaptor protein transforms fibroblasts and functions in transformation by the BCR-ABL oncogene

21 January 2018

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Inhibition of Grb2 and Crkl proteins results in growth inhibition of Philadelphia chromosome positive leukemic cells

21 January 2018

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The BCR/ABL oncogene alters interaction of the adapter proteins CRKL and CRK with cellular proteins

21 January 2018

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Increased neutrophil respiratory burst in bcr-null mutants

21 January 2018

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Bcr/Abl associated leukemogenesis in bcr null mutant mice

21 January 2018

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The leukaemic oncoproteins Bcr-Abl and Tel-Abl (ETV6/Abl) have altered substrate preferences and activate similar intracellular signalling pathways.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1038/SJ.ONC.1205452

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29 November 2017

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