The tumor suppressor activity of SOCS-1. (Q44039019)

29 November 2017

title

The tumor suppressor activity of SOCS-1. (English)

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29 November 2017

Paulo de Sepulveda

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Robert Rottapel

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Patrice Dubreuil

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Subburaj Ilangumaran

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29 November 2017

Christopher Neale

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29 November 2017

Jose La Rose

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29 November 2017

Jenny M-Y Ho

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29 November 2017

Melody H-H Nguyen

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29 November 2017

Dwayne Barber

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29 November 2017

language of work or name

English

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publication date

1 June 2002

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29 November 2017

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29 November 2017

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29 November 2017

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29 November 2017

page(s)

4351-4362

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SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine.

29 November 2017

cites work

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Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase

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Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein

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Direct interaction of Jak1 and v-Abl is required for v-Abl-induced activation of STATs and proliferation

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Suppressor of cytokine signaling-1 inhibits VAV function through protein degradation.

21 January 2018

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Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation

21 January 2018

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A new protein containing an SH2 domain that inhibits JAK kinases

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Interleukin 2 signaling involves the phosphorylation of Stat proteins

21 January 2018

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Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation

21 January 2018

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The role of phosphotyrosine phosphatases in haematopoietic cell signal transduction

21 January 2018

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The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

21 January 2018

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The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2.

21 January 2018

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The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

21 January 2018

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A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia

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Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1

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The Cbl protooncoprotein: a negative regulator of immune receptor signal transduction

21 January 2018

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SOCS3 is essential in the regulation of fetal liver erythropoiesis

21 January 2018

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SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality

21 January 2018

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Chronic myelogenous leukemia.

21 January 2018

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The TEL-Jak2 oncoprotein induces Socs1 expression and altered cytokine response in Ba/F3 cells

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Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor necrosis factor alpha-induced cell death in fibroblasts

21 January 2018

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Inactivation of SSI-1, a JAK/STAT inhibitor, in human hepatocellular carcinomas, as revealed by two-dimensional electrophoresis

21 January 2018

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Negative regulation of cytokine signaling: STAT-induced STAT inhibitor

21 January 2018

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Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice

21 January 2018

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Structure and function of a new STAT-induced STAT inhibitor

21 January 2018

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Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signaling

21 January 2018

1 reference

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Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction

21 January 2018

1 reference

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SOCS-1/JAB/SSI-1 Can Bind to and Suppress Tec Protein-tyrosine Kinase

21 January 2018

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Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes

21 January 2018

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Regulation of B cell signal transduction by SH2-containing protein-tyrosine phosphatases

21 January 2018

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Negative regulation of the JAK/STAT pathway

21 January 2018

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Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1.

21 January 2018

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A family of cytokine-inducible inhibitors of signalling

21 January 2018

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Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change.

21 January 2018

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Lymphohematopoietic progenitors immortalized by a retroviral vector harboring a dominant-negative retinoic acid receptor can recapitulate lymphoid, myeloid, and erythroid development

21 January 2018

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21 January 2018

VHL: a very hip ligase

1 reference

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The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop

21 January 2018

1 reference

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Negative regulation of cytokine signaling pathways

21 January 2018

1 reference

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The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

21 January 2018

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Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases

21 January 2018

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Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

21 January 2018

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High-intensity p38 kinase activity is critical for p21(cip1) induction and the antiproliferative function of G(i) protein-coupled receptors

21 January 2018

1 reference

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inferred from DOI database lookup

7 January 2021

based on heuristic

Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205537

inferred from DOI database lookup

7 January 2021

based on heuristic

SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205537

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/SJ.ONC.1205537

1 reference

Dimensions Publication ID

29 November 2017

1045177493

0 references

1 reference