MicroRNA-25-dependent up-regulation of NADPH oxidase 4 (NOX4) mediates hypercholesterolemia-induced oxidative/nitrative stress and subsequent dysfunction in the heart (Q44005262)

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scientific article published on 27 May 2013

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English	MicroRNA-25-dependent up-regulation of NADPH oxidase 4 (NOX4) mediates hypercholesterolemia-induced oxidative/nitrative stress and subsequent dysfunction in the heart	scientific article published on 27 May 2013

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scholarly article

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Europe PubMed Central

PubMed publication ID

28 November 2017

MicroRNA-25-dependent up-regulation of NADPH oxidase 4 (NOX4) mediates hypercholesterolemia-induced oxidative/nitrative stress and subsequent dysfunction in the heart (English)

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Europe PubMed Central

PubMed publication ID

28 November 2017

hypercholesterolemia

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inferred from title

object named as

Gergő Szűcs

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object named as

Péter Bencsik

11

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Krisztina Kupai

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object named as

Csaba Csonka

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Peter Ferdinandy

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object named as

Péter Ferdinandy

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28 November 2017

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object named as

Tamás Csont

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28 November 2017

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Nóra Faragó

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28 November 2017

László G Puskás

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László G Puskás

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28 November 2017

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Agnes Zvara

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28 November 2017

author name string

Zoltán V Varga

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28 November 2017

Renáta Gáspár

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28 November 2017

János Pálóczi

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28 November 2017

Zsolt Rázga

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28 November 2017

László Tiszlavicz

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28 November 2017

Anikó Görbe

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28 November 2017

publication date

27 May 2013

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28 November 2017

Journal of Molecular and Cellular Cardiology

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28 November 2017

62

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28 November 2017

111-121

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28 November 2017

Executive Summary: Heart Disease and Stroke Statistics--2012 Update: A Report From the American Heart Association

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Cardiovascular risk factors and systolic and diastolic cardiac function: a tissue Doppler and speckle tracking echocardiographic study

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Hyperlipidemia induced by a cholesterol-rich diet leads to enhanced peroxynitrite formation in rat hearts.

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Cardiac systolic and diastolic dysfunction after a cholesterol-rich diet

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Loss of pacing-induced preconditioning in rat hearts: role of nitric oxide and cholesterol-enriched diet

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Effect of hypercholesterolemia on myocardial necrosis and apoptosis in the setting of ischemia-reperfusion

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Cholesterol diet leads to attenuation of ischemic preconditioning-induced cardiac protection: the role of connexin 43

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Cholesterol diet-induced hyperlipidemia impairs the cardioprotective effect of postconditioning: role of peroxynitrite

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Hypercholesterolemia increases myocardial oxidative and nitrosative stress thereby leading to cardiac dysfunction in apoB-100 transgenic mice

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The involvement of superoxide and iNOS-derived NO in cardiac dysfunction induced by pro-inflammatory cytokines

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MicroRNAs: novel regulators in cardiac development and disease

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Measurement of myocardial infarct size in preclinical studies.

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Classic preconditioning decreases the harmful accumulation of nitric oxide during ischemia and reperfusion in rat hearts

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Gas chromatographic-mass spectrometric determination of brain levels of alpha-cholest-8-en-3beta-ol (lathosterol).

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Purification of high-quality micro RNA from the heart tissue.

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Gene and protein expression changes in response to normoxic perfusion in mouse hearts.

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Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets

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Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites

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Nox4-derived reactive oxygen species mediate cardiomyocyte injury in early type 1 diabetes

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Nox4 NADPH oxidase mediates oxidative stress and apoptosis caused by TNF-alpha in cerebral vascular endothelial cells

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Angiotensin II-induced mitochondrial Nox4 is a major endogenous source of oxidative stress in kidney tubular cells

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Transcriptional regulation of Nox4 by histone deacetylases in human endothelial cells.

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Biglycan protects cardiomyocytes against hypoxia/reoxygenation injury: Role of nitric oxide

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Impact of haloperidol and risperidone on gene expression profile in the rat cortex

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A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

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The role of orphan nuclear receptors in the regulation of cholesterol homeostasis

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Differential microRNA response to a high-cholesterol, high-fat diet in livers of low and high LDL-C baboons

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OxLDL causes both epigenetic modification and signaling regulation on the microRNA-29b gene: novel mechanisms for cardiovascular diseases.

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The Rat Genome Database 2009: variation, ontologies and pathways

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miR-25 targets TNF-related apoptosis inducing ligand (TRAIL) death receptor-4 and promotes apoptosis resistance in cholangiocarcinoma

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MicroRNA-25 promotes cell migration and invasion in esophageal squamous cell carcinoma

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Identification of renox, an NAD(P)H oxidase in kidney

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Upregulation of Nox4 by hypertrophic stimuli promotes apoptosis and mitochondrial dysfunction in cardiac myocytes.

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New insight into the Nox4 subcellular localization in HEK293 cells: first monoclonal antibodies against Nox4.

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A 28-kDa splice variant of NADPH oxidase-4 is nuclear-localized and involved in redox signaling in vascular cells

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Increased oxidative stress in the nucleus caused by Nox4 mediates oxidation of HDAC4 and cardiac hypertrophy.

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NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart.

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NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis.

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NOX4 activity is determined by mRNA levels and reveals a unique pattern of ROS generation.

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Regulation of NADPH Oxidase Activity Is Associated with miRNA-25-Mediated NOX4 Expression in Experimental Diabetic Nephropathy

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Identifiers

10.1016/J.YJMCC.2013.05.009

1 reference

Europe PubMed Central

PubMed publication ID

28 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 November 2017

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