Nuclear retention of Fbw7 by specific inhibitors of nuclear export leads to Notch1 degradation in pancreatic cancer (Q33976883)

30 July 2017

title

Nuclear retention of Fbw7 by specific inhibitors of nuclear export leads to Notch1 degradation in pancreatic cancer (English)

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30 July 2017

1 reference

Jiankun Gao

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30 July 2017

Asfar S Azmi

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30 July 2017

Amro Aboukameel

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30 July 2017

Michael Kauffman

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30 July 2017

Sharon Shacham

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30 July 2017

Abdul-Badi Abou-Samra

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30 July 2017

Ramzi M Mohammad

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30 July 2017

language of work or name

English

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publication date

1 June 2014

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30 July 2017

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inferred from page(s)

published in

Oncotarget

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30 July 2017

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30 July 2017

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30 July 2017

page(s)

3444-3454

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CRM1 and BRAF inhibition synergize and induce tumor regression in BRAF-mutant melanoma

30 July 2017

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KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia.

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5 July 2018

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Selective inhibitors of nuclear export block pancreatic cancer cell proliferation and reduce tumor growth in mice

5 July 2018

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5 July 2018

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FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation

5 July 2018

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Serum- and glucocorticoid-inducible kinase 1 (SGK1) controls Notch1 signaling by downregulation of protein stability through Fbw7 ubiquitin ligase

5 July 2018

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5 July 2018

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5 July 2018

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CRM1-mediated nuclear export of proteins and drug resistance in cancer

5 July 2018

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Notch signaling in cancer.

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog

5 July 2018

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Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor

5 July 2018

1 reference

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Notch signaling: cell fate control and signal integration in development

5 July 2018

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Phase I trial of elactocin

5 July 2018

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Notch on the cutting edge

5 July 2018

1 reference

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Prognostic value of CRM1 in pancreas cancer

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24899509

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Down-regulation of notch-1 inhibits invasion by inactivation of nuclear factor-kappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24899509

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.18632/ONCOTARGET.1813

0 references

PMC publication ID

4116494

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30 July 2017

1 reference