Mathematical modeling of chimeric TCR triggering predicts the magnitude of target lysis and its impairment by TCR downmodulation (Q33960119)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20220093%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

title

Mathematical modeling of chimeric TCR triggering predicts the magnitude of target lysis and its impairment by TCR downmodulation (English)

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19 January 2020

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19 January 2020

Scott E James

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19 January 2020

Philip D Greenberg

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19 January 2020

Michael C Jensen

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19 January 2020

Yukang Lin

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19 January 2020

Jinjuan Wang

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19 January 2020

Lihua E Budde

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19 January 2020

Brian G Till

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19 January 2020

Andrew A Raubitschek

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19 January 2020

Stephen J Forman

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19 January 2020

language of work or name

English

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publication date

10 March 2010

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19 January 2020

published in

Journal of Immunology

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19 January 2020

volume

184

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19 January 2020

issue

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19 January 2020

page(s)

4284-4294

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Antibody-mediated B-cell depletion before adoptive immunotherapy with T cells expressing CD20-specific chimeric T-cell receptors facilitates eradication of leukemia in immunocompetent mice

19 January 2020

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5 July 2018

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5 July 2018

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Cytotoxic T lymphocytes kill multiple targets simultaneously via spatiotemporal uncoupling of lytic and stimulatory synapses.

5 July 2018

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5 July 2018

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Adoptive transfer of T cells modified with a humanized chimeric receptor gene inhibits growth of Lewis-Y-expressing tumors in mice

5 July 2018

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T cell receptor binding kinetics required for T cell activation depend on the density of cognate ligand on the antigen-presenting cell.

5 July 2018

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Cellular immunotherapy for follicular lymphoma using genetically modified CD20-specific CD8+ cytotoxic T lymphocytes

5 July 2018

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Activation of resting human primary T cells with chimeric receptors: costimulation from CD28, inducible costimulator, CD134, and CD137 in series with signals from the TCR zeta chain

5 July 2018

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Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells.

5 July 2018

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Targeting tumours with genetically enhanced T lymphocytes

5 July 2018

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Progressive differentiation and selection of the fittest in the immune response

5 July 2018

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Redirecting mouse CTL against colon carcinoma: superior signaling efficacy of single-chain variable domain chimeras containing TCR-zeta vs Fc epsilon RI-gamma

5 July 2018

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Functional balance between T cell chimeric receptor density and tumor associated antigen density: CTL mediated cytolysis and lymphokine production

5 July 2018

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Efficient discrimination between different densities of target antigen by tetracycline-regulatable T bodies

5 July 2018

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CD20 is a molecular target for scFvFc:zeta receptor redirected T cells: implications for cellular immunotherapy of CD20+ malignancy

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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29 October 2018

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29 October 2018

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29 October 2018

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29 October 2018

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Conjugation between cloned human NK cells (H7.8) and K562/MOLT4 tumor cell systems: saturability, binding parameters, and population distribution of conjugates

29 October 2018

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12 December 2020

Serial TCR engagement and down-modulation by peptide:MHC molecule ligands: relationship to the quality of individual TCR signaling events

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12 December 2020

Treatment of metastatic renal cell carcinoma with autologous T-lymphocytes genetically retargeted against carbonic anhydrase IX: first clinical experience

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12 December 2020

Adoptive transfer of chimeric antigen receptor re-directed cytolytic T lymphocyte clones in patients with neuroblastoma

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12 December 2020

Redirected Perforin-Dependent Lysis of Colon Carcinoma by Ex Vivo Genetically Engineered CTL

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12 December 2020

Activated TCRs remain marked for internalization after dissociation from pMHC

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12 December 2020

Identifiers

DOI

10.4049/JIMMUNOL.0903701

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20220093%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

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19 January 2020

PubMed publication ID

20220093

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