The insert region of Rac1 is essential for membrane ruffling but not cellular transformation (Q33967934)

30 July 2017

title

The insert region of Rac1 is essential for membrane ruffling but not cellular transformation (English)

1 reference

30 July 2017

A E Karnoub

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30 July 2017

C J Der

series ordinal

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30 July 2017

S L Campbell

series ordinal

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30 July 2017

language of work or name

English

0 references

publication date

1 April 2001

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Molecular and Cellular Biology

30 July 2017

published in

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30 July 2017

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30 July 2017

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30 July 2017

page(s)

2847-2857

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A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCzeta signaling and cell transformation

30 July 2017

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Arachidonic acid induces the activation of the stress-activated protein kinase, membrane ruffling and H2O2 production via a small GTPase Rac1.

5 July 2018

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Loop 6 of RhoA confers specificity for effector binding, stress fiber formation, and cellular transformation

5 July 2018

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5 July 2018

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Effector domain mutants of Rho dissociate cytoskeletal changes from nuclear signaling and cellular transformation

5 July 2018

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An activated Rac mutant functions as a dominant negative for membrane ruffling

5 July 2018

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5 July 2018

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A Rac1 effector site controlling mitogenesis through superoxide production

5 July 2018

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Transformation activity of Cdc42 requires a region unique to Rho-related proteins

5 July 2018

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Rac1, and not Rac2, is involved in the regulation of the intracellular hydrogen peroxide level in HepG2 cells

5 July 2018

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Role of Rac1 and oxygen radicals in collagenase-1 expression induced by cell shape change

5 July 2018

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5 July 2018

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Epidermal Growth Factor Induction of the c-jun Promoter by a Rac Pathway

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Definition of the switch surface in the solution structure of Cdc42Hs

5 July 2018

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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rac1 regulates a cytokine-stimulated, redox-dependent pathway necessary for NF-kappaB activation

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Different structural organization of Ras and Rho effector domains

5 July 2018

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5 July 2018

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5 July 2018

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Multiple DNA elements are required for the growth regulation of the mouse E2F1 promoter

5 July 2018

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A role for Rac in Tiam1-induced membrane ruffling and invasion

5 July 2018

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A 68-kDa kinase and NADPH oxidase component p67phox are targets for Cdc42Hs and Rac1 in neutrophils

5 July 2018

1 reference

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An essential role for Rac in Ras transformation

5 July 2018

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An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G 1

5 July 2018

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The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86914

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

5 July 2018

1 reference

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The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

5 July 2018

1 reference

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Requirement for generation of H2O2 for platelet-derived growth factor signal transduction

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86914

Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86914

Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions

5 July 2018

1 reference

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"Peptide walking" is a novel method for mapping functional domains in proteins. Its application to the Rac1-dependent activation of NADPH oxidase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86914

Rac GTPase interacts with GAPs and target proteins through multiple effector sites.

5 July 2018

1 reference

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The ras protein family: evolutionary tree and role of conserved amino acids

5 July 2018

1 reference

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The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

5 July 2018

1 reference

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Lipid products of phosphoinositide 3-kinase interact with Rac1 GTPase and stimulate GDP dissociation

5 July 2018

1 reference

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Rho family proteins and Ras transformation: the RHOad less traveled gets congested.

29 October 2018

1 reference

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Mutational analysis of novel effector domains in Rac1 involved in the activation of nicotinamide adenine dinucleotide phosphate (reduced) oxidase

29 October 2018

1 reference

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RhoA effector mutants reveal distinct effector pathways for cytoskeletal reorganization, SRF activation and transformation.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86914

Regulation of reactive-oxygen-species generation in fibroblasts by Rac1.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86914

Multiple signalling pathways lead to the activation of the nuclear factor kappaB by the Rho family of GTPases

29 October 2018

1 reference

12 December 2020

Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1

1 reference

12 December 2020

Characterization of the Effector-specifying Domain of Rac Involved in NADPH Oxidase Activation

1 reference

12 December 2020

Rac binding to p67(phox). Structural basis for interactions of the Rac1 effector region and insert region with components of the respiratory burst oxidase

1 reference

12 December 2020

Interaction between Cdc42Hs and RhoGDI Is Mediated through the Rho Insert Region

1 reference

12 December 2020

Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species

1 reference

12 December 2020

Backbone dynamics of inactive, active, and effector-bound Cdc42Hs from measurements of (15)N relaxation parameters at multiple field strengths

1 reference

12 December 2020

Rac "insert region" is a novel effector region that is implicated in the activation of NADPH oxidase, but not PAK65

1 reference

12 December 2020

10.1128/MCB.21.8.2847-2857.2001

Identifiers

DOI

1 reference

release_twrqgs2xjfgxfcx6ldjbjbjrim

30 July 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/twrqgs2xjfgxfcx6ldjbjbjrim

24 November 2022

mapped directly with Wikidata item

PMC publication ID

86914

1 reference

30 July 2017

1 reference