The oncoprotein E2A-Pbx1a collaborates with Hoxa9 to acutely transform primary bone marrow cells (Q33959545)

30 July 2017

title

The oncoprotein E2A-Pbx1a collaborates with Hoxa9 to acutely transform primary bone marrow cells (English)

1 reference

30 July 2017

1 reference

U Thorsteinsdottir

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30 July 2017

J Krosl

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30 July 2017

E Kroon

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30 July 2017

A Haman

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30 July 2017

T Hoang

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30 July 2017

G Sauvageau

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30 July 2017

language of work or name

English

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publication date

1 September 1999

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Molecular and Cellular Biology

30 July 2017

published in

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30 July 2017

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30 July 2017

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30 July 2017

page(s)

6355-6366

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Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation

30 July 2017

cites work

1 reference

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Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes

5 July 2018

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Cellular proliferation and transformation induced by HOXB4 and HOXB3 proteins involves cooperation with PBX1.

5 July 2018

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Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b

5 July 2018

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Functional and regulatory interactions between Hox and extradenticle genes

5 July 2018

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AbdB-Like Hox Proteins Stabilize DNA Binding by the Meis1 Homeodomain Proteins

5 July 2018

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Cross-regulation in the mouse HoxB complex: the expression of Hoxb2 in rhombomere 4 is regulated by Hoxb1

5 July 2018

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Functional dissection of a transcriptionally active, target-specific Hox-Pbx complex

5 July 2018

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Distinct HOX N-terminal arm residues are responsible for specificity of DNA recognition by HOX monomers and HOX.PBX heterodimers

5 July 2018

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The Abd-B-like Hox homeodomain proteins can be subdivided by the ability to form complexes with Pbx1a on a novel DNA target

5 July 2018

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Overexpression of HOXB3 in hematopoietic cells causes defective lymphoid development and progressive myeloproliferation

5 July 2018

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Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia

5 July 2018

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The Hox cooperativity motif of the chimeric oncoprotein E2a-Pbx1 is necessary and sufficient for oncogenesis

5 July 2018

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The role of HOX homeobox genes in normal and leukemic hematopoiesis

5 July 2018

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Engrailed and Hox homeodomain proteins contain a related Pbx interaction motif that recognizes a common structure present in Pbx.

5 July 2018

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Hox homeodomain proteins exhibit selective complex stabilities with Pbx and DNA.

5 July 2018

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The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9

5 July 2018

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Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia

5 July 2018

1 reference

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DNA-binding by oncoprotein E2a-Pbx1 is important for blocking differentiation but dispensable for fibroblast transformation.

5 July 2018

1 reference

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Conditional immortalization of mouse myelomonocytic, megakaryocytic and mast cell progenitors by the Hox-2.4 homeobox gene.

5 July 2018

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E2A-Pbx1, the t(1;19) translocation protein of human pre-B-cell acute lymphocytic leukemia, causes acute myeloid leukemia in mice

5 July 2018

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Transformation properties of the E2a-Pbx1 chimeric oncoprotein: fusion with E2a is essential, but the Pbx1 homeodomain is dispensable

5 July 2018

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Hox genes in vertebrate development

5 July 2018

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Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84606

Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84606

Cooperative interactions between HOX and PBX proteins mediated by a conserved peptide motif

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84606

Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84606

Stage- and lineage-specific expression of the HOXA10 homeobox gene in normal and leukemic hematopoietic cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84606

Self-renewal of hemopoietic stem cells during mixed colony formation in vitro

5 July 2018

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Pre-B cell leukemia associated with chromosome translocation 1;19.

5 July 2018

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Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

5 July 2018

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Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84606

A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84606

Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84606

Chimeric homeobox gene E2A-PBX1 induces proliferation, apoptosis, and malignant lymphomas in transgenic mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84606

The DNA binding specificity of Ultrabithorax is modulated by cooperative interactions with extradenticle, another homeoprotein.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84606

Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/pbx

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84606

Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/10454582

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/MCB.19.9.6355

1 reference

30 July 2017

1 reference

30 July 2017

1 reference