The 3' IgH regulatory region: a complex structure in a search for a function (Q33957718)

30 July 2017

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title

The 3' IgH regulatory region: a complex structure in a search for a function (English)

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30 July 2017

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A A Khamlichi

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30 July 2017

E Pinaud

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30 July 2017

C Decourt

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30 July 2017

C Chauveau

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30 July 2017

M Cogné

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30 July 2017

language of work or name

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1 January 2000

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30 July 2017

published in

Advances in Immunology

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30 July 2017

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30 July 2017

page(s)

317-345

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Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis

30 July 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Temporal expression of a V(H) promoter-Cmu transgene linked to the IgH HS1,2 enhancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Physiological activation of the IgH 3' enhancer in B lineage cells is not blocked by Pax-5

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Tumor necrosis factor receptor superfamily members and their ligands

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Lipopolysaccharide-dependent transactivation of the temporally regulated immunoglobulin heavy chain 3' enhancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

The enhancer shift: a model to explain the developmental control of IgH gene expression in B-lineage cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

The Maf transcription factors: regulators of differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Rate of replication of the murine immunoglobulin heavy-chain locus: evidence that the region is part of a single replicon

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

The role of BSAP (Pax-5) in B-cell development

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Palindromic structure of the IgH 3'locus control region.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

A region of the 20 bp repeats lies 3' of human Ig Calpha1 and Calpha2 genes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Nuclear matrix attachment occurs in several regions of the IgH locus

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

A class switch control region at the 3′ end of the immunoglobulin heavy chain locus

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

The mouse IgH 3'-enhancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

NF-kappa B RelA-deficient lymphocytes: normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responses

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Independent immunoglobulin class-switch events occurring in a single myeloma cell line

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

The beta-globin LCR is not necessary for an open chromatin structure or developmentally regulated transcription of the native mouse beta-globin locus.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Evidence that a single replication fork proceeds from early to late replicating domains in the IgH locus in a non-B cell line

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Combinatorial regulation of transcription II: The immunoglobulin mu heavy chain gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Chromatin as an essential part of the transcriptional mechanim

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

High-avidity human IgG kappa monoclonal antibodies from a novel strain of minilocus transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Pax-5 (BSAP) recruits Ets proto-oncogene family proteins to form functional ternary complexes on a B-cell-specific promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Selective synergy of immunoglobulin enhancer elements in B-cell development: a characteristic of kappa light chain enhancers, but not heavy chain enhancers

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Identification of Ets-like lymphoid specific elements within the immunoglobulin heavy chain 3' enhancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

IgM receptor-mediated transactivation of the IgH 3' enhancer couples a novel Elf-1-AP-1 protein complex to the developmental control of enhancer function.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Regulation of B cell development by variable gene complexity in mice reconstituted with human immunoglobulin yeast artificial chromosomes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Myeloma mutant with a novel 3' flanking region: loss of normal sequence and insertion of repetitive elements leads to decreased transcription but normal processing of the alpha heavy-chain gene products

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Integration of an Epstein-Barr virus episome 3' into the gene encoding immunoglobulin heavy-chain alpha 1 in a lymphoblastoid cell line.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Transcriptional regulation during B cell development

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Analysis of mice containing a targeted deletion of beta-globin locus control region 5' hypersensitive site 3.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Shutdown of class switch recombination by deletion of a switch region control element.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Helix-loo-helix proteins in the regulation of immunoglobulin gene transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Eukaryotic transcription: an interlaced network of transcription factors and chromatin-modifying machines

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Tandem repeats 3' of the IGHA genes in the human immunoglobulin heavy chain gene cluster

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

An enhancer at the 3' end of the mouse immunoglobulin heavy chain locus

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Immunoglobulin gene transcription ceases upon deletion of a distant enhancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

The effects of E mu, 3'alpha (hs 1,2) and 3'kappa enhancers on mutation of an Ig-VDJ-Cgamma2a Ig heavy gene in cultured B cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

NFE, a new transcriptional activator that facilitates p50 and c-Rel-dependent IgH 3' enhancer activity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Antigen-specific human antibodies from mice comprising four distinct genetic modifications

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Identification of a locus control region in the immunoglobulin heavy-chain locus that deregulates c-myc expression in plasmacytoma and Burkitt's lymphoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

The immunoglobulin heavy chain locus control region increases histone acetylation along linked c-myc genes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

A unique role for enhancers is revealed during early mouse development

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Class switching in B cells lacking 3' immunoglobulin heavy chain enhancers.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Regulation of beta-globin gene expression: straightening out the locus.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

The immunoglobulin heavy chain locus contains another B-cell-specific 3' enhancer close to the alpha constant region

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Repression of the immunoglobulin heavy chain 3' enhancer by helix-loop-helix protein Id3 via a functionally important E47/E12 binding site: implications for developmental control of enhancer function.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Regulation of the replication of the murine immunoglobulin heavy chain gene locus: evaluation of the role of the 3' regulatory region

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Identification of 3' alpha-hs4, a novel Ig heavy chain enhancer element regulated at multiple stages of B cell differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Enhancer complexes located downstream of both human immunoglobulin Calpha genes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

The effect of the rat immunoglobulin heavy-chain 3' enhancer is position dependent

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Differential interactions between the immunoglobulin heavy chain mu intron and 3' enhancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Identification of Bach2 as a B-cell-specific partner for small maf proteins that negatively regulate the immunoglobulin heavy chain gene 3' enhancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Expression and regulation of immunoglobulin heavy chain gene transfected into lymphoid cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Reciprocal chromosome translocation between c-myc and immunoglobulin gamma 2b genes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of-function experiments

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Essential functions of Pax5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Adjacent DNA elements dominantly restrict the ubiquitous activity of a novel chromatin-opening region to specific tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

A second B cell-specific enhancer 3' of the immunoglobulin heavy-chain locus

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Identification of a homolog of the C alpha 3'/hs3 enhancer and of an allelic variant of the 3'IgH/hs1,2 enhancer downstream of the human immunoglobulin alpha 1 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Clonal selection and learning in the antibody system

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

An interleukin-2 signal relieves BSAP (Pax5)-mediated repression of the immunoglobulin J chain gene

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

CpG-rich sequences close to the site of duplication within the human IGH constant region.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

The Ig heavy chain intronic enhancer core region is necessary and sufficient to promote efficient class switch recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

An expressed neo(r) cassette provides required functions of the 1gamma2b exon for class switching.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

NF-HB (BSAP) is a repressor of the murine immunoglobulin heavy-chain 3' alpha enhancer at early stages of B-cell differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Accessibility control of antigen-receptor variable-region gene assembly: role of cis-acting elements

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

The immunoglobulin class switch: beyond "accessibility".

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

B cells lacking RelB are defective in proliferative responses, but undergo normal B cell maturation to Ig secretion and Ig class switching

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Human immunoglobulin transgenes undergo rearrangement, somatic mutation and class switching in mice that lack endogenous IgM.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Somatic generation of antibody diversity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Evaluation of the role of the 3'alpha heavy chain enhancer [3'alpha E(hs1,2)] in Vh gene somatic hypermutation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Reevaluation of 3'Ekappa function in stage- and lineage-specific rearrangement and somatic hypermutation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Antibody expression from the core region of the human IgH locus reconstructed in transgenic mice using bacteriophage P1 clones

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

The diversity of antigen-specific monoclonal antibodies from transgenic mice bearing human immunoglobulin gene miniloci

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Dependence of BSAP repressor and activator functions on BSAP concentration

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

The Pax-5 gene is alternatively spliced during B-cell development

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

Mechanism and regulation of immunoglobulin isotype switching.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2800%2975008-5

7 January 2021

10.1016/S0065-2776(00)75008-5

Identifiers

DOI

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30 July 2017

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