Rapamycin prevents the development and progression of mutant epidermal growth factor receptor lung tumors with the acquired resistance mutation T790M. (Q33948614)

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English	Rapamycin prevents the development and progression of mutant epidermal growth factor receptor lung tumors with the acquired resistance mutation T790M.	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

30 July 2017

Rapamycin prevents the development and progression of mutant epidermal growth factor receptor lung tumors with the acquired resistance mutation T790M. (English)

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Europe PubMed Central

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30 July 2017

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Kwok-Kin Wong

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30 July 2017

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William Pao

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30 July 2017

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Pasi A Jänne

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Lucia Regales

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30 July 2017

author name string

Shigeru Kawabata

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30 July 2017

José R Mercado-Matos

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30 July 2017

M Christine Hollander

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30 July 2017

Danielle Donahue

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30 July 2017

Willie Wilson

5

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30 July 2017

Mohit Butaney

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Phillip A Dennis

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30 July 2017

publication date

12 June 2014

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30 July 2017

1824-1832

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30 July 2017

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4110638/fullTextXML

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Targeting mTOR to overcome epidermal growth factor receptor tyrosine kinase inhibitor resistance in non-small cell lung cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110638

5 July 2018

Epidermal growth factor receptor tyrosine kinase inhibitor-resistant disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110638

5 July 2018

Epidermal growth factor receptor inhibition in lung cancer: status 2012.

1 reference

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Genetic and biochemical alterations in non-small cell lung cancer

1 reference

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mTOR signaling in growth control and disease

1 reference

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5 July 2018

Pretreatment epidermal growth factor receptor (EGFR) T790M mutation predicts shorter EGFR tyrosine kinase inhibitor response duration in patients with non-small-cell lung cancer.

1 reference

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Disease flare after tyrosine kinase inhibitor discontinuation in patients with EGFR-mutant lung cancer and acquired resistance to erlotinib or gefitinib: implications for clinical trial design.

1 reference

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Rational, biologically based treatment of EGFR-mutant non-small-cell lung cancer

1 reference

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mTOR-mediated activation of p70 S6K induces differentiation of pluripotent human embryonic stem cells

1 reference

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Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade

1 reference

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5 July 2018

Novel mutant-selective EGFR kinase inhibitors against EGFR T790M

1 reference

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

1 reference

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Lung cancer in never smokers--a different disease

1 reference

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Development of new mouse lung tumor models expressing EGFR T790M mutants associated with clinical resistance to kinase inhibitors

1 reference

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Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors

1 reference

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5 July 2018

Conditional expression of the mutant Ki-rasG12C allele results in formation of benign lung adenomas: development of a novel mouse lung tumor model

1 reference

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Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain

1 reference

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EGFR mutation and resistance of non-small-cell lung cancer to gefitinib

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Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways

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Exploiting the mTOR paradox for disease prevention

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Identification of a highly effective rapamycin schedule that markedly reduces the size, multiplicity, and phenotypic progression of tobacco carcinogen-induced murine lung tumors.

1 reference

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29 October 2018

Identifiers

10.1016/J.CELREP.2014.05.039

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

ResearchGate publication ID

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