Regulation of Fc∈RI signaling in mast cells by G protein-coupled receptor kinase 2 and its RH domain. (Q33947182)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24904059%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

title

Regulation of Fc∈RI signaling in mast cells by G protein-coupled receptor kinase 2 and its RH domain (English)

1 reference

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G protein-coupled receptor

20 March 2020

main subject

0 references

1 reference

Narayanan Parameswaran

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20 March 2020

author name string

Hariharan Subramanian

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20 March 2020

Kshitij Gupta

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20 March 2020

Hydar Ali

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20 March 2020

language of work or name

English

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publication date

1 July 2014

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Journal of Biological Chemistry

20 March 2020

published in

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20 March 2020

volume

289

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20 March 2020

issue

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20 March 2020

page(s)

20917-20927

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Targeting cardiac β-adrenergic signaling via GRK2 inhibition for heart failure therapy

20 March 2020

cites work

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Roles for NHERF1 and NHERF2 on the regulation of C3a receptor signaling in human mast cells

5 July 2018

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Phosphorylation of C3a receptor at multiple sites mediates desensitization, β-arrestin-2 recruitment and inhibition of NF-κB activity in mast cells

5 July 2018

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Developmental origin and functional specialization of mast cell subsets

5 July 2018

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Mast cell anaphylatoxin receptor expression can enhance IgE-dependent skin inflammation in mice

5 July 2018

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IgE and mast cells in allergic disease

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Regulation of C3a receptor signaling in human mast cells by G protein coupled receptor kinases

5 July 2018

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Roles of phosphorylation-dependent and -independent mechanisms in the regulation of histamine H2 receptor by G protein-coupled receptor kinase 2.

5 July 2018

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Distinct and Shared Roles of β-Arrestin-1 and β-Arrestin-2 on the Regulation of C3a Receptor Signaling in Human Mast Cells

5 July 2018

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Amplification of cytokine production through synergistic activation of NFAT and AP-1 following stimulation of mast cells with antigen and IL-33

5 July 2018

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Taking the heart failure battle inside the cell: small molecule targeting of Gβγ subunits

5 July 2018

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Prostaglandin E2 activates and utilizes mTORC2 as a central signaling locus for the regulation of mast cell chemotaxis and mediator release

5 July 2018

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The complex G protein-coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targets

5 July 2018

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Comparison of the anti-allergic activity of Syk inhibitors with optimized Syk siRNAs in FcepsilonRI-activated RBL-2H3 basophilic cells

5 July 2018

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Phosphorylation-independent regulation of metabotropic glutamate receptor 5 desensitization and internalization by G protein-coupled receptor kinase 2 in neurons

5 July 2018

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New developments in mast cell biology

5 July 2018

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EGF transregulates opioid receptors through EGFR-mediated GRK2 phosphorylation and activation.

5 July 2018

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Generation of anaphylatoxins by human beta-tryptase from C3, C4, and C5

5 July 2018

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A current understanding of Fc epsilon RI-dependent mast cell activation

5 July 2018

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Phosphorylation of p38 by GRK2 at the docking groove unveils a novel mechanism for inactivating p38MAPK.

5 July 2018

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5 July 2018

Omalizumab for asthma

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Molecular regulation of mast cell activation

5 July 2018

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A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension.

5 July 2018

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Distinct regulation of C3a-induced MCP-1/CCL2 and RANTES/CCL5 production in human mast cells by extracellular signal regulated kinase and PI3 kinase.

5 July 2018

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Targeting Syk as a treatment for allergic and autoimmune disorders

5 July 2018

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G Protein-coupled receptor kinase 2 regulator of G protein signaling homology domain binds to both metabotropic glutamate receptor 1a and Galphaq to attenuate signaling

5 July 2018

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G protein-coupled receptor Kinase 2/G alpha q/11 interaction. A novel surface on a regulator of G protein signaling homology domain for binding G alpha subunits.

5 July 2018

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5 July 2018

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5 July 2018

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Distinct roles of receptor phosphorylation, G protein usage, and mitogen-activated protein kinase activation on platelet activating factor-induced leukotriene C(4) generation and chemokine production

5 July 2018

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5 July 2018

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Akt-dependent cytokine production in mast cells

5 July 2018

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5 July 2018

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5 July 2018

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Phosphorylation of the type 1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C

5 July 2018

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Effect of different G protein-coupled receptor kinases on phosphorylation and desensitization of the alpha1B-adrenergic receptor

5 July 2018

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Enhanced myocardial relaxation in vivo in transgenic mice overexpressing the beta2-adrenergic receptor is associated with reduced phospholamban protein

5 July 2018

1 reference

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Desensitization of the isolated beta 2-adrenergic receptor by beta-adrenergic receptor kinase, cAMP-dependent protein kinase, and protein kinase C occurs via distinct molecular mechanisms

5 July 2018

1 reference

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Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthma

5 July 2018

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Crossref

https://api.crossref.org/works/10.1074%2FJBC.M113.523969

Induced Syk deletion leads to suppressed allergic responses but has no effect on neutrophil or monocyte migration in vivo.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M113.523969

Syk and Lyn mediate distinct Syk phosphorylation events in FcɛRI-signal transduction: implications for regulation of IgE-mediated degranulation

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M113.523969

An intranasal Syk-kinase inhibitor (R112) improves the symptoms of seasonal allergic rhinitis in a park environment

21 January 2018

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12 December 2020

Expression of high-affinity binding of human immunoglobulin E by transfected cells

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12 December 2020

The membrane-proximal portion of CD3 epsilon associates with the serine/threonine kinase GRK2

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12 December 2020

Characterization of GRK2 RH domain-dependent regulation of GPCR coupling to heterotrimeric G proteins

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12 December 2020

G protein-coupled receptor kinases

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12 December 2020

Cutting edge: Differential regulation of chemoattractant receptor-induced degranulation and chemokine production by receptor phosphorylation

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Identifiers

DOI

10.1074/JBC.M113.523969

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24904059%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24904059%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

PubMed publication ID

24904059

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24904059%20AND%20SRC:MED&resulttype=core&format=json