Proteasome inhibition: a new strategy in cancer treatment (Q33945453)

30 July 2017

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title

Proteasome inhibition: a new strategy in cancer treatment (English)

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30 July 2017

Adams J

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30 July 2017

Palombella VJ

series ordinal

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30 July 2017

Elliott PJ

series ordinal

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30 July 2017

publication date

1 May 2000

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Investigational New Drugs

30 July 2017

published in

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30 July 2017

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30 July 2017

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30 July 2017

page(s)

109-121

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A ubiquitin ligase complex essential for the NF-kappaB, Wnt/Wingless, and Hedgehog signaling pathways

30 July 2017

cites work

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12 December 2020

Phosphorylation of human CDC25B phosphatase by CDK1-cyclin A triggers its proteasome-dependent degradation

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12 December 2020

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway

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12 December 2020

Proteasome subunits, low‐molecular‐mass polypeptides 2 and 7 are hyperexpressed by target cells in autoimmune thyroid disease but not in insulin‐dependent diabetes mellitus: implications for autoimmunity

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12 December 2020

Angiogenesis mediated by soluble forms of E-selectin and vascular cell adhesion molecule-1.

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12 December 2020

Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched chain and small neutral amino acids

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12 December 2020

A proteolytic system that compensates for loss of proteasome function

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12 December 2020

Proteasome inhibitors induce apoptosis in glucocorticoid-resistant chronic lymphocytic leukemic lymphocytes

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12 December 2020

Potent and selective inhibitors of the proteasome: dipeptidyl boronic acids

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12 December 2020

Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin

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12 December 2020

Suppression of TNF-alpha-induced apoptosis by NF-kappaB

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12 December 2020

NF-kappa B and Rel: participants in a multiform transcriptional regulatory system.

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12 December 2020

Degradation of tyrosine aminotransferase (TAT) via the ubiquitin-proteasome pathway

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12 December 2020

Probing the specificity of the bovine pituitary multicatalytic proteinase complex by inhibitors, activators, and by chemical modification

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12 December 2020

Apoptosis induction resulting from proteasome inhibition

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12 December 2020

Proteasome-dependent regulation of p21WAF1/CIP1 expression

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12 December 2020

An inhibitor of HIV-1 protease modulates proteasome activity, antigen presentation, and T cell responses

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12 December 2020

The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin.

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12 December 2020

Involvement of the proteasome in the programmed cell death of NGF-deprived sympathetic neurons.

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12 December 2020

c-Fos degradation by the proteasome. An early, Bcl-2-regulated step in apoptosis

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12 December 2020

Role of the proteasome and NF-kappaB in streptococcal cell wall-induced polyarthritis

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12 December 2020

The ubiquitin-proteasome pathway: on protein death and cell life

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12 December 2020

Inhibition of NF-kappa B activity induces apoptosis in murine hepatocytes

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12 December 2020

Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27

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12 December 2020

Detailed analysis of cell cycle kinetics upon proteasome inhibition

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12 December 2020

Rapamycin inhibits proteasome activator expression and proteasome activity

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12 December 2020

Selective proteasome inhibitors: modulators of antigen presentation?

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12 December 2020

p53-dependent cell cycle arrest induced by N-acetyl-L-leucinyl-L-leucinyl-L-norleucinal in platelet-derived growth factor-stimulated human fibroblasts

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12 December 2020

Activation of the cell death program by inhibition of proteasome function

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12 December 2020

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12 December 2020

Novel dipeptidyl proteasome inhibitors overcome Bcl-2 protective function and selectively accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed, but not normal, human fibroblasts

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12 December 2020

Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis

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12 December 2020

Inhibition of nuclear factor kappaB activation attenuates apoptosis resistance in lymphoid cells

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12 December 2020

Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control

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12 December 2020

p53-dependent induction of apoptosis by proteasome inhibitors

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12 December 2020

Alteration of rat liver 20S proteasome activities by age and food restriction.

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12 December 2020

Basal and human papillomavirus E6 oncoprotein-induced degradation of Myc proteins by the ubiquitin pathway

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12 December 2020

The NF-kappa B and I kappa B proteins: new discoveries and insights

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12 December 2020

Tumor growth inhibition induced in a murine model of human Burkitt's lymphoma by a proteasome inhibitor.

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12 December 2020

The proteasome inhibitor PS-341 in cancer therapy.

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12 December 2020

Proteasome inhibitors activate stress kinases and induce Hsp72. Diverse effects on apoptosis

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12 December 2020

Cyclosporine A is an uncompetitive inhibitor of proteasome activity and prevents NF‐κB activation

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12 December 2020

Ubiquitin-dependent protein degradation

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12 December 2020

The proteasome pathway is required for cytokine-induced endothelial-leukocyte adhesion molecule expression

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12 December 2020

Bcl-2 activates the transcription factor NFkappaB through the degradation of the cytoplasmic inhibitor IkappaBalpha

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12 December 2020

Bcl-2 suppresses apoptosis resulting from disruption of the NF-kappa B survival pathway

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12 December 2020

NF-kappa B: ten years after

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12 December 2020

Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 A resolution

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12 December 2020

The antitumor drug aclacinomycin A, which inhibits the degradation of ubiquitinated proteins, shows selectivity for the chymotrypsin-like activity of the bovine pituitary 20 S proteasome

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12 December 2020

The proteasome is involved in angiogenesis

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12 December 2020

Selective inhibition of the chymotrypsin-like activity of the 20S proteasome by 5-methoxy-1-indanone dipeptide benzamides

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12 December 2020

ch-IAP1, a Member of the Inhibitor-of-Apoptosis Protein Family, Is a Mediator of the Antiapoptotic Activity of the v-Rel Oncoprotein

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12 December 2020

Role of proteasomes in T cell activation and proliferation

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12 December 2020

Adhesion molecules in tumor metastasis

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12 December 2020

Proteasome alpha-type subunit C9 is a primary target of autoantibodies in sera of patients with myositis and systemic lupus erythematosus

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12 December 2020

Prostate carcinoma cell death resulting from inhibition of proteasome activity is independent of functional Bcl-2 and p53

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12 December 2020

Proteasome inhibition: A novel mechanism to combat asthma

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12 December 2020

Proteasome inhibition enhances the stability of mouse Cu/Zn superoxide dismutase with mutations linked to familial amyotrophic lateral sclerosis

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12 December 2020

In vivo ubiquitination and proteasome-mediated degradation of p53(1)

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12 December 2020

Roles of ubiquitin-mediated proteolysis in cell cycle control

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12 December 2020

Ubiquitin-dependent destruction of topoisomerase I is stimulated by the antitumor drug camptothecin

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12 December 2020

Cardioprotective effects of a novel proteasome inhibitor following ischemia and reperfusion in the isolated perfused rat heart

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12 December 2020

IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell survival

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12 December 2020

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

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12 December 2020

Inhibition of proteasome, apoptosis and sensitization to tumour necrosis factor alpha: do they always go together?

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12 December 2020

The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B

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12 December 2020

How proteolysis drives the cell cycle

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12 December 2020

Proteasome inhibitors: valuable new tools for cell biologists

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12 December 2020

Degradation of c-Fos by the 26S proteasome is accelerated by c-Jun and multiple protein kinases

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12 December 2020

Proteasome inhibitors: a novel class of potent and effective antitumor agents.

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12 December 2020

The proteasome inhibitor lactacystin induces apoptosis and sensitizes chemo- and radioresistant human chronic lymphocytic leukaemia lymphocytes to TNF-alpha-initiated apoptosis

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12 December 2020

Covalent modification of the active site threonine of proteasomal beta subunits and the Escherichia coli homolog HslV by a new class of inhibitors

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12 December 2020

TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

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12 December 2020

Lactacystin, a specific inhibitor of the proteasome, induces apoptosis in human monoblast U937 cells

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12 December 2020

An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

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12 December 2020

The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis

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12 December 2020

Prevention of brefeldin A-induced resistance to teniposide by the proteasome inhibitor MG-132: involvement of NF-kappaB activation in drug resistance.

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12 December 2020

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12 December 2020

Stable inhibition of nuclear factor kappaB in cancer cells does not increase sensitivity to cytotoxic drugs

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12 December 2020

Distinct mechanisms control the accumulation of the Rb-related p107 and p130 proteins during cell growth

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12 December 2020

NF-kappa B: a lesson in family values

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12 December 2020

Requirement of NF-κB Activation to Suppress p53-Independent Apoptosis Induced by Oncogenic Ras

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12 December 2020

Active site-directed inhibitors of Rhodococcus 20 S proteasome. Kinetics and mechanism

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12 December 2020

Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB

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12 December 2020

Treatment of established relapsing experimental autoimmune encephalomyelitis with the proteasome inhibitor PS-519

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12 December 2020

Angiogenesis and angiogenesis inhibition: an overview

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12 December 2020

Eliminating All Obstacles: Regulated Proteolysis in the Eukaryotic Cell Cycle

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12 December 2020

Proteasomes play an essential role in thymocyte apoptosis

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12 December 2020

Mechanistic studies on the inactivation of the proteasome by lactacystin: a central role for clasto-lactacystin beta-lactone

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12 December 2020

Enhanced in vitro cytotoxicity and cytostasis of the combination of onconase with a proteasome inhibitor

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12 December 2020

Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers.

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12 December 2020

NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

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12 December 2020

The ubiquitin-proteasome pathway in cancer

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12 December 2020

The Bcl-2 protein family: arbiters of cell survival

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12 December 2020

Identifiers

DOI

10.1023/A:1006321828515

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Dimensions Publication ID

30 July 2017

1053498283

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