p53 mutational spectra and the role of methylated CpG sequences (Q33933769)

30 July 2017

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title

p53 mutational spectra and the role of methylated CpG sequences (English)

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30 July 2017

Pfeifer GP

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30 July 2017

language of work or name

English

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publication date

1 May 2000

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30 July 2017

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30 July 2017

volume

450

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30 July 2017

issue

1-2

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30 July 2017

page(s)

155-166

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IARC Database of p53 gene mutations in human tumors and cell lines: updated compilation, revised formats and new visualisation tools

30 July 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Aflatoxin B1 induces the transversion of G-->T in codon 249 of the p53 tumor suppressor gene in human hepatocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Slow repair of pyrimidine dimers at p53 mutation hotspots in skin cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Cytosine methylation determines hot spots of DNA damage in the human P53 gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

p53 tumor suppressor gene: from the basic research laboratory to the clinic--an abridged historical perspective

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

On the origins of tumor mutations in cancer genes: insights from the p53 gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Silent and multiple mutations in p53 and the question of the hypermutability of tumors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

5-Methylcytosine as an Endogenous Mutagen in the Human LDL Receptor and p53 Genes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Ubiquitous and tenacious methylation of the CpG site in codon 248 of the p53 gene may explain its frequent appearance as a mutational hot spot in human cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

The role of DNA methylation in cancer genetic and epigenetics

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Mutagenic and epigenetic effects of DNA methylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

N-nitroso-N-methylurea-induced rat mammary tumors arise from cells with preexisting oncogenic Hras1 gene mutations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

The Wavelengths in Sunlight Effective in Producing Skin Cancer: A Theoretical Analysis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Specific UV-induced mutation spectrum in the p53 gene of skin tumors from DNA-repair-deficient xeroderma pigmentosum patients

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Changes in DNA base sequence induced by targeted mutagenesis of lambda phage by ultraviolet light

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Mutagenic specificity of ultraviolet light

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Mutagenic specificity of solar UV light in nucleotide excision repair-deficient rodent cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Formation and processing of UV photoproducts: effects of DNA sequence and chromatin environment

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Carcinogenic epoxides of benzo[a]pyrene and cyclopenta[cd]pyrene induce base substitutions via specific transversions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Effect of excision repair by diploid human fibroblasts on the kinds and locations of mutations induced by (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10- tetrahydrobenzo[a]pyrene in the coding region of the HPRT gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Sequence specificity of mutations induced by benzo[a]pyrene-7,8-diol-9,10-epoxide at endogenous aprt gene in CHO cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Benzo[a]pyrene-induced murine skin tumors exhibit frequent and characteristic G to T mutations in the p53 gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

A specific spectrum of p53 mutations in lung cancer from smokers: review of mutations compiled in the IARC p53 database

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Molecular epidemiology of human cancer risk: gene-environment interactions and p53 mutation spectrum in human lung cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Mutational hot spot in the p53 gene in human hepatocellular carcinomas

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

5-Methylcytosine, Gene Regulation, and Cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

The essentials of DNA methylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Molecular basis of base substitution hotspots in Escherichia coli

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Recent human germ-line mutation: inferences from patients with hemophilia B.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Transition mutations at CpG dinucleotides are the most frequent in vivo spontaneous single-based substitution mutation in the human HPRT gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

The expected equilibrium of the CpG dinucleotide in vertebrate genomes under a mutation model

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Analysis of CpG suppression in methylated and nonmethylated species

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Formation and repair of DNA lesions in the p53 gene: relation to cancer mutations?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

A sensitive genetic assay for the detection of cytosine deamination: determination of rate constants and the activation energy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Instability and decay of the primary structure of DNA

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

The rate of hydrolytic deamination of 5-methylcytosine in double-stranded DNA

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Heat- and alkali-induced deamination of 5-methylcytosine and cytosine residues in DNA

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

DNA cytosine methylation and heat-induced deamination

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Spontaneous deamination of cytosine and 5-methylcytosine residues in DNA and replacement of 5-methylcytosine residues with cytosine residues

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

The CpG dinucleotide and human genetic disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase

7 January 2021

2 references

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

7 January 2021

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

inferred from DOI database lookup

7 January 2021

based on heuristic

3,N4-ethenocytosine, a highly mutagenic adduct, is a primary substrate for Escherichia coli double-stranded uracil-DNA glycosylase and human mismatch-specific thymine-DNA glycosylase

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

A 55-kDa protein isolated from human cells shows DNA glycosylase activity toward 3,N4-ethenocytosine and the G/T mismatch

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

The rate of CpG mutation in Alu repetitive elements within the p53 tumor suppressor gene in the primate germline

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

The DNA repair gene MBD4 (MED1) is mutated in human carcinomas with microsatellite instability

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Endogenous DNA adducts: potential and paradox

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Endogenous lesions, S-phase-independent spontaneous mutations, and evolutionary strategies for base excision repair

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Endogenous oxidative damage of deoxycytidine in DNA.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

High frequency mutagenesis by a DNA methyltransferase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Cytosine deaminations catalyzed by DNA cytosine methyltransferases are unlikely to be the major cause of mutational hot spots at sites of cytosine methylation in Escherichia coli

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

HhaI and HpaII DNA methyltransferases bind DNA mismatches, methylate uracil and block DNA repair

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Oxidative damage to 5-methylcytosine in DNA.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

The p53 codon 249 mutational hotspot in hepatocellular carcinoma is not related to selective formation or persistence of aflatoxin B1 adducts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

In vivo mapping of a DNA adduct at nucleotide resolution: detection of pyrimidine (6-4) pyrimidone photoproducts by ligation-mediated polymerase chain reaction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Binding of transcription factors creates hot spots for UV photoproducts in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Detection of DNA adducts at the DNA sequence level by ligation-mediated PCR

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Slow repair of bulky DNA adducts along the nontranscribed strand of the human p53 gene may explain the strand bias of transversion mutations in cancers.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Involvement of 5-methylcytosine in sunlight-induced mutagenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

In vivo evidence that UV-induced C-->T mutations at dipyrimidine sites could result from the replicative bypass of cis-syn cyclobutane dimers or their deamination products

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Formation of Cyclobutane dimers and (6-4) Photoproducts upon Far-UV Photolysis of 5-Methylcytosine-Containing Dinucleoside Monophosphates

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Sequence and time-dependent deamination of cytosine bases in UVB-induced cyclobutane pyrimidine dimers in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

The role of UV-B light in skin carcinogenesis through the analysis of p53 mutations in squamous cell carcinomas of hairless mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Frequent p53 alterations but low incidence of ras mutations in UV-B-induced skin tumors of hairless mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

p53 mutations in cutaneous lesions induced in the hairless mouse by a solar ultraviolet light simulator

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

p53 Mutations in hairless SKH-hr1 mouse skin tumors induced by a solar simulator

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Carcinogen biomarkers related to smoking and upper aerodigestive tract cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Targeting of lung cancer mutational hotspots by polycyclic aromatic hydrocarbons

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

A study of tobacco carcinogenesis. VII. The role of higher polycyclic hydrocarbons.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Cytosine methylation in a CpG sequence leads to enhanced reactivity with Benzo[a]pyrene diol epoxide that correlates with a conformational change

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Methylation of CpG dinucleotides in the lacI gene of the Big Blue transgenic mouse

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Preferential repair and strand-specific repair of benzo[a]pyrene diol epoxide adducts in the HPRT gene of diploid human fibroblasts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Transgenic systems for in vivo mutation analysis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

Squamous cell and basal cell skin carcinoma and rarer histologic types of skin cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900022-1

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0027-5107(00)00022-1

1 reference

30 July 2017

1 reference