Tyrosine kinase inhibitors targeted to the epidermal growth factor receptor subfamily: role as anticancer agents (Q33914337)

30 July 2017

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title

Tyrosine kinase inhibitors targeted to the epidermal growth factor receptor subfamily: role as anticancer agents (English)

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30 July 2017

Noonberg SB

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30 July 2017

Benz CC

series ordinal

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30 July 2017

publication date

1 April 2000

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30 July 2017

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30 July 2017

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30 July 2017

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30 July 2017

page(s)

753-767

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p185HER2 monoclonal antibody has antiproliferative effects in vitro and sensitizes human breast tumor cells to tumor necrosis factor

30 July 2017

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Recombinant humanized anti-HER2 antibody (Herceptin) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts

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12 December 2020

Activating SRC mutation in a subset of advanced human colon cancers

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12 December 2020

Single-chain antibody-mediated intracellular retention of ErbB-2 impairs Neu differentiation factor and epidermal growth factor signaling

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12 December 2020

Preclinical testing of an anti-erbB-2 recombinant toxin

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12 December 2020

Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment

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12 December 2020

Selective killing of tumor cells using EGF or TGF alpha-Pseudomonas exotoxin chimeric molecules

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12 December 2020

Eradication of established tumors by a fully human monoclonal antibody to the epidermal growth factor receptor without concomitant chemotherapy

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12 December 2020

In vitro and in vivo activity of a recombinant toxin, OLX-209, which targets the erbB-2 oncoprotein

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12 December 2020

Human pancreatic RNase1-human epidermal growth factor fusion: an entirely human 'immunotoxin analog' with cytotoxic properties against squamous cell carcinomas

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12 December 2020

Targeted inhibition of tumour cell growth by a bispecific single-chain toxin containing an antibody domain and TGF alpha

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12 December 2020

Genistein, a specific inhibitor of tyrosine-specific protein kinases

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12 December 2020

Cytotoxic activity of epidermal growth factor-genistein against breast cancer cells

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12 December 2020

Peptide containing the BCR oligomerization domain (AA 1-160) reverses the transformed phenotype of p210bcr-abl positive 32D myeloid leukemia cells

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12 December 2020

Use of a Pharmacophore Model for the Design of EGF-R Tyrosine Kinase Inhibitors: 4-(Phenylamino)pyrazolo[3,4-d]pyrimidines

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12 December 2020

Inhibition of signaling from Type 1 receptor tyrosine kinases via intracellular expression of single-chain antibodies

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12 December 2020

In vivo eradication of human BCR/ABL-positive leukemia cells with an ABL kinase inhibitor

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12 December 2020

Cytolytic and cytostatic properties of an anti-human Fc gammaRI (CD64) x epidermal growth factor bispecific fusion protein

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12 December 2020

Suramin: a novel antineoplastic agent with multiple potential mechanisms of action

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12 December 2020

Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors

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12 December 2020

Epidermal growth factor receptor inhibition by a monoclonal antibody as anticancer therapy.

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12 December 2020

Prognostic significance of the receptor for epidermal growth factor in human mammary carcinomas

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12 December 2020

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12 December 2020

A bivalent single-chain antibody-toxin specific for ErbB-2 and the EGF receptor

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12 December 2020

Protein kinase inhibitors: the tyrosine-specific protein kinases

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12 December 2020

Synthesis and biological evaluation of aeroplysinin analogues: a new class of receptor tyrosine kinase inhibitors

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12 December 2020

Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice

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12 December 2020

Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

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12 December 2020

Crystal structure of the tyrosine kinase domain of the human insulin receptor

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12 December 2020

Solution structure of acidic fibroblast growth factor bound to 1,3, 6-naphthalenetrisulfonate: a minimal model for the anti-tumoral action of suramins and suradistas

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12 December 2020

1001 protein kinases redux--towards 2000.

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12 December 2020

Down-modulation of an oncogene protein product and reversion of the transformed phenotype by monoclonal antibodies

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12 December 2020

Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

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12 December 2020

In vitro and in vivo stability and anti-tumour efficacy of an anti-EGFR/anti-CD3 F(ab')2 bispecific monoclonal antibody

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12 December 2020

Tyrosine kinase inhibition: an approach to drug development

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12 December 2020

Phase Ia/Ib trial of bispecific antibody MDX-210 in patients with advanced breast or ovarian cancer that overexpresses the proto-oncogene HER-2/neu

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12 December 2020

RETRACTED: 4,5-Dianilinophthalimide: a protein-tyrosine kinase inhibitor with selectivity for the epidermal growth factor receptor signal transduction pathway and potent in vivo antitumor activity

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12 December 2020

Intracellular expression of a single-chain antibody directed to the EGFR leads to growth inhibition of tumor cells

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12 December 2020

Small molecule inhibitors of the platelet-derived growth factor receptor, the fibroblast growth factor receptor, and Src family tyrosine kinases

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12 December 2020

Bispecific antibody-dependent cellular cytotoxicity of HER2/neu-overexpressing tumor cells by Fc gamma receptor type I-expressing effector cells

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12 December 2020

Alpha-cyano-beta-hydroxy-beta-methyl-N-[4-(trifluoromethoxy)phenyl] propenamide: an inhibitor of the epidermal growth factor receptor tyrosine kinase with potent cytotoxic activity against breast cancer cells.

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12 December 2020

Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification

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12 December 2020

Differential pp60c-src activity in well and poorly differentiated human colon carcinomas and cell lines

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12 December 2020

SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types

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12 December 2020

In vivo toxicity, pharmacokinetics, and anticancer activity of Genistein linked to recombinant human epidermal growth factor.

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12 December 2020

Antitumor activity of anti-epidermal growth factor receptor monoclonal antibodies and cisplatin in ten human head and neck squamous cell carcinoma lines.

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12 December 2020

Cooperation between oncogenes

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12 December 2020

Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain.

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12 December 2020

Structure of the protein tyrosine kinase domain of C-terminal Src kinase (CSK) in complex with staurosporine

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12 December 2020

4-(Phenylamino)pyrrolopyrimidines: potent and selective, ATP site directed inhibitors of the EGF-receptor protein tyrosine kinase

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12 December 2020

Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members

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12 December 2020

Efficient reversion of simian sarcoma virus-transformation and inhibition of growth factor-induced mitogenesis by suramin

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12 December 2020

Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase

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12 December 2020

Tyrosine kinase inhibitors, emodin and its derivative repress HER-2/neu-induced cellular transformation and metastasis-associated properties.

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12 December 2020

The protein kinase family: conserved features and deduced phylogeny of the catalytic domains

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12 December 2020

Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft model

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12 December 2020

Selective inhibition of cell proliferation and BCR-ABL phosphorylation in acute lymphoblastic leukemia cells expressing Mr 190,000 BCR-ABL protein by a tyrosine kinase inhibitor (CGP-57148).

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12 December 2020

Targeting tumor cellsvia EGF receptors: Selective toxicity of an HBEGF-toxin fusion protein

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12 December 2020

Crystal structure of the ligand-binding domain of the receptor tyrosine kinase EphB2

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12 December 2020

Rational design and synthesis of a novel anti-leukemic agent targeting Bruton's tyrosine kinase (BTK), LFM-A13 [alpha-cyano-beta-hydroxy-beta-methyl-N-(2, 5-dibromophenyl)propenamide]

1 reference

12 December 2020

Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis

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12 December 2020

Involvement of p27KIP1 in G1 arrest mediated by an anti-epidermal growth factor receptor monoclonal antibody

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12 December 2020

Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents

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12 December 2020

Activity of anti-erbB-2 recombinant toxin OLX-209 on lung cancer cell lines in the absence of erbB-2 gene amplification

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12 December 2020

Tyrosine kinase inhibitors. 2. Synthesis of 2,2'-dithiobis(1H-indole-3-alkanamides) and investigation of their inhibitory activity against epidermal growth factor receptor and pp60v-src protein tyrosine kinases

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12 December 2020

Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

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12 December 2020

Inactivation and Activation of Liver Phosphorylase

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12 December 2020

SRC as a target for anti-cancer drugs

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12 December 2020

Recombinant immunotoxins directed against the c-erb-2/HER2/neu oncogene product: in vitro cytotoxicity, pharmacokinetics, and in vivo efficacy studies in xenograft models

1 reference

12 December 2020

Tyrosine kinase inhibitors. 10. Isomeric 4-[(3-bromophenyl)amino]pyrido[d]-pyrimidines are potent ATP binding site inhibitors of the tyrosine kinase function of the epidermal growth factor receptor

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12 December 2020

The current state of oncogenes and cancer: experimental approaches for analyzing oncogenetic events in human cancer

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12 December 2020

Conversion of phosphorylase b to phosphorylase a in muscle extracts

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12 December 2020

Inhibitors of tyrosine kinase

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12 December 2020

In vivo toxicity and pharmacokinetic features of B43(Anti-CD19)-Genistein immunoconjugate

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12 December 2020

A monoclonal antibody against the c-erbB-2 protein enhances the cytotoxicity of cis-diamminedichloroplatinum against human breast and ovarian tumor cell lines

1 reference

12 December 2020

Differential expression of alternatively spliced c-erbB-2 mRNA in primary tumors, lymph node metastases, and bone marrow micrometastases from breast cancer patients

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12 December 2020

Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor

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12 December 2020

Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

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12 December 2020

Systemic treatment with a recombinant erbB-2 receptor-specific tumor toxin efficiently reduces pulmonary metastases in mice injected with genetically modified carcinoma cells

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12 December 2020

Transformation by Rous sarcoma virus: A cellular substrate for transformation-specific protein phosphorylation contains phosphotyrosine

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12 December 2020

Bacterial expression and characterization of recombinant biologically active anti-tyrosine kinase receptor antibody forms

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12 December 2020

Suppression of metastasis formation by a recombinant single chain antibody-toxin targeted to full-length and oncogenic variant EGF receptors

1 reference

12 December 2020

A specific inhibitor of the epidermal growth factor receptor tyrosine kinase

1 reference

12 December 2020

EGFR blockade by tyrosine kinase inhibitor or monoclonal antibody inhibits growth, directs terminal differentiation and induces apoptosis in the human squamous cell carcinoma HN5.

1 reference

12 December 2020

Recombinant heregulin-Pseudomonas exotoxin fusion proteins: interactions with the heregulin receptors and antitumor activity in vivo

1 reference

12 December 2020

Expression of an oncogenic mutant EGF receptor markedly increases the sensitivity of cells to an EGF-receptor-specific antibody-toxin

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12 December 2020

Role of target antigen in bispecific-antibody-mediated killing of human glioblastoma cells: a pre-clinical study.

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12 December 2020

Naamidine A is an antagonist of the epidermal growth factor receptor and an in vivo active antitumor agent

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12 December 2020

Tyrphostin AG957, a tyrosine kinase inhibitor with anti-BCR/ABL tyrosine kinase activity restores beta1 integrin-mediated adhesion and inhibitory signaling in chronic myelogenous leukemia hematopoietic progenitors

1 reference

12 December 2020

Antitumor activity of sequential treatment with topotecan and anti-epidermal growth factor receptor monoclonal antibody C225.

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12 December 2020

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12 December 2020

Design of a potent peptide inhibitor of the epidermal growth factor receptor tyrosine kinase utilizing sequences based on the natural phosphorylation sites of phospholipase C-gamma 1

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12 December 2020

Suramin inhibits the growth of non-small-cell lung cancer cells that express the epidermal growth factor receptor

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12 December 2020

Effect of Suramin on Human Esophageal Cancer Cells in Vitro and in Vivo

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12 December 2020

Biotherapy of B-cell precursor leukemia by targeting genistein to CD19-associated tyrosine kinases

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12 December 2020

Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor

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12 December 2020

Cloning and cytotoxicity of fusion proteins of EGF and angiogenin

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12 December 2020

Therapy of human transitional cell carcinoma of the bladder by oral administration of the epidermal growth factor receptor protein tyrosine kinase inhibitor 4,5-dianilinophthalimide

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12 December 2020

Single-step purification of bispecific monoclonal antibodies for immunotherapeutic use by hydrophobic interaction chromatography

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12 December 2020

Studies on a new epidermal growth factor-receptor kinase inhibitor, erbstatin, produced by MH435-hF3

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12 December 2020

Tyrosine kinase inhibitors. 14. Structure-activity relationships for methylamino-substituted derivatives of 4-[(3-bromophenyl)amino]-6-(methylamino)-pyrido[3,4-d]pyrimidine (PD 158780), a potent and specific inhibitor of the tyrosine kinase activity

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12 December 2020

10.2165/00003495-200059040-00003

Identifiers

DOI

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Dimensions Publication ID

30 July 2017

1032968092

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