Genetics of body-weight regulation (Q33892344)

29 July 2017

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title

Genetics of body-weight regulation (English)

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29 July 2017

Barsh GS

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29 July 2017

Farooqi IS

series ordinal

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29 July 2017

O'Rahilly S

series ordinal

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29 July 2017

language of work or name

English

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publication date

1 April 2000

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29 July 2017

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29 July 2017

volume

404

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29 July 2017

issue

6778

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29 July 2017

page(s)

644-651

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The response to long-term overfeeding in identical twins

29 July 2017

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A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2

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The quantitative trait locus on chromosome 2 for serum leptin levels is confirmed in African-Americans

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Effects of parabiosis of obese with diabetes and normal mice

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Positional cloning of the mouse obese gene and its human homologue

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7 January 2021

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Role of leptin in the neuroendocrine response to fasting

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Signals that regulate food intake and energy homeostasis

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The agouti gene: turned on to yellow

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A molecular model for the genetic and phenotypic characteristics of the mouse lethal yellow (Ay) mutation

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A C-terminal fragment of Agouti-related protein increases feeding and antagonizes the effect of alpha-melanocyte stimulating hormone in vivo

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7 January 2021

The role of agouti-related protein in regulating body weight

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Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice

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7 January 2021

Overexpression of Agrt leads to obesity in transgenic mice

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7 January 2021

Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related Protein

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7 January 2021

Targeted disruption of the melanocortin-4 receptor results in obesity in mice

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From lesions to leptin: hypothalamic control of food intake and body weight.

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Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area.

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Unraveling the central nervous system pathways underlying responses to leptin

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Melanocortin receptors in leptin effects

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Proopiomelanocortin Neurons Are Direct Targets for Leptin in the Hypothalamus

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Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides.

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Independent and Additive Effects of Central POMC and Leptin Pathways on Murine Obesity

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Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin

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Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors

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Targeted deletion of the Vgf gene indicates that the encoded secretory peptide precursor plays a novel role in the regulation of energy balance

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Mice lacking melanin-concentrating hormone are hypophagic and lean

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Imprinting-mutation mechanisms in Prader-Willi syndrome

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Linkage mapping in 29 Bardet-Biedl syndrome families confirms loci in chromosomal regions 11q13, 15q22.3-q23, and 16q21.

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Linkage localization of Börjeson-Forssman-Lehmann syndrome.

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A leptin missense mutation associated with hypogonadism and morbid obesity.

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Congenital leptin deficiency is associated with severe early-onset obesity in humans

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A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

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Genetically transmitted obesity in rodents

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Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

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A frameshift mutation in MC4R associated with dominantly inherited human obesity

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Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans

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7 January 2021

A frameshift mutation in human MC4R is associated with a dominant form of obesity

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7 January 2021

Identification and functional analysis of novel human melanocortin-4 receptor variants

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7 January 2021

Functional characterization of mutations in melanocortin-4 receptor associated with human obesity

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7 January 2021

Phenotypes in three pedigrees with autosomal dominant obesity caused by haploinsufficiency mutations in the melanocortin-4 receptor gene

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7 January 2021

Effects of recombinant leptin therapy in a child with congenital leptin deficiency.

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7 January 2021

Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity

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7 January 2021

Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene

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A paradigm for finding genes for a complex human trait: polycystic ovary syndrome and follistatin

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Brown adipose tissue, beta 3-adrenergic receptors, and obesity

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The Biochemical Effect of the Naturally Occurring Trp644→Arg Mutation on Human β3‐Adrenoceptor Activity

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Cultured retinal capillary pericytes die by apoptosis after an abrupt fluctuation from high to low glucose levels: a comparative study with retinal capillary endothelial cells

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7 January 2021

Meta-analysis of the association of the Trp64Arg polymorphism in the beta3 adrenergic receptor with body mass index

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7 January 2021

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

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7 January 2021

Thirty-seven candidate genes for polycystic ovary syndrome: strongest evidence for linkage is with follistatin

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7 January 2021

Prospects for whole-genome linkage disequilibrium mapping of common disease genes

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7 January 2021

Testing the robustness of the likelihood-ratio test in a variance-component quantitative-trait loci-mapping procedure

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7 January 2021

Selected methodological issues in meiotic mapping of obesity genes in humans: issues of power and efficiency

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7 January 2021

A general approach to single-nucleotide polymorphism discovery.

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Large scale ENU screens in the mouse: genetics meets genomics

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7 January 2021

Mouse mutagenesis-systematic studies of mammalian gene function

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7 January 2021

Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells

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7 January 2021

The mouse mahogany locus encodes a transmembrane form of human attractin

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7 January 2021

An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians

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7 January 2021

Genome scan for human obesity and linkage to markers in 20q13.

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7 January 2021

Growth quantitative trait loci (QTL) on mouse chromosome 10 in a Quackenbush-Swiss x C57BL/6J backcross

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7 January 2021

Identification of four chromosomal loci determining obesity in a multifactorial mouse model

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7 January 2021

Mapping of body weight loci on mouse chromosome X.

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7 January 2021

Detection of obesity QTLs on mouse chromosomes 1 and 7 by selective DNA pooling

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7 January 2021

Sensitivity to dietary obesity linked to a locus on chromosome 15 in a CAST/Ei x C57BL/6J F2 intercross

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7 January 2021

Obesity QTLs on Mouse Chromosomes 2 and 17

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7 January 2021

Identification of an obesity quantitative trait locus on mouse chromosome 2 and evidence of linkage to body fat and insulin on the human homologous region 20q.

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7 January 2021

Genetic loci controlling body fat, lipoprotein metabolism, and insulin levels in a multifactorial mouse model

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7 January 2021

Genetics of obesity in KK mouse and effects of A(y) allele on quantitative regulation

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7 January 2021

Gender-influenced obesity QTLs identified in a cross involving the KK type II diabetes-prone mouse strain

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7 January 2021

Identification and expression cloning of a leptin receptor, OB-R

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7 January 2021

Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice

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7 January 2021

Abnormal splicing of the leptin receptor in diabetic mice

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7 January 2021

Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation

1 reference

7 January 2021

Molecular characterization of the mouse agouti locus.

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7 January 2021

Hypogonadism and obesity in mice with a targeted deletion of the Nhlh2 gene

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7 January 2021

Implication of tubby proteins as transcription factors by structure-based functional analysis

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7 January 2021

A candidate gene for the mouse mutation tubby

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7 January 2021

Dimensions Publication ID

Identifiers

DOI

10.1038/35007519

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1008495974

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