Initial testing of the aurora kinase A inhibitor MLN8237 by the Pediatric Preclinical Testing Program (PPTP). (Q33867046)

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17 January 2020

title

Initial testing of the aurora kinase A inhibitor MLN8237 by the Pediatric Preclinical Testing Program (PPTP) (English)

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17 January 2020

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17 January 2020

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17 January 2020

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17 January 2020

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17 January 2020

Peter J Houghton

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17 January 2020

John M Maris

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17 January 2020

Malcolm A Smith

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17 January 2020

E Anders Kolb

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17 January 2020

Stephen T Keir

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17 January 2020

Hernan Carol

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17 January 2020

Christopher L Morton

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17 January 2020

Jianrong Wu

series ordinal

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17 January 2020

publication date

1 July 2010

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17 January 2020

published in

Pediatric Blood & Cancer

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17 January 2020

volume

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17 January 2020

issue

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17 January 2020

page(s)

26-34

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Small molecule aurora kinases inhibitors.

17 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874079

The inhibition of Aurora A abrogates the mitotic delay induced by microtubule perturbing agents

28 July 2018

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UA62784, a novel inhibitor of centromere protein E kinesin-like protein

28 July 2018

1 reference

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Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma

28 July 2018

1 reference

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Aurora kinase A inhibition and paclitaxel as targeted combination therapy for head and neck squamous cell carcinoma

28 July 2018

1 reference

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Aurora kinase A inhibition leads to p73-dependent apoptosis in p53-deficient cancer cells

28 July 2018

1 reference

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Aurora-A transcriptional silencing and vincristine treatment show a synergistic effect in human tumor cells.

28 July 2018

1 reference

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The Aurora kinase family in cell division and cancer.

28 July 2018

1 reference

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Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874079

Aurora kinases as anticancer drug targets

28 July 2018

1 reference

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A fluorescence microplate cytotoxicity assay with a 4-log dynamic range that identifies synergistic drug combinations

28 July 2018

1 reference

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Targeted anti-mitotic therapies: can we improve on tubulin agents?

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874079

Credentialing preclinical pediatric xenograft models using gene expression and tissue microarray analysis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874079

Tubulin-associated drug targets: Aurora kinases, Polo-like kinases, and others

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874079

Evaluation of the antitumor efficacy, pharmacokinetics, and pharmacodynamics of the histone deacetylase inhibitor depsipeptide in childhood cancer models in vivo

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874079

In vivo evaluation of ixabepilone (BMS247550), a novel epothilone B derivative, against pediatric cancer models

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874079

AuroraA overexpression overrides the mitotic spindle checkpoint triggered by nocodazole, a microtubule destabilizer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874079

Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874079

The Aurora kinases: role in cell transformation and tumorigenesis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874079

AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874079

Experimental chemotherapy of human medulloblastoma cell lines and transplantable xenografts with bifunctional alkylating agents

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874079

Unholy matrimony: Aurora A and N-Myc as malignant partners in neuroblastoma.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874079

Aurora-A kinase is essential for bipolar spindle formation and early development

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874079

Initial testing (stage 1) of the proteasome inhibitor bortezomib by the pediatric preclinical testing program.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874079

Potentiation of kinesin spindle protein inhibitor-induced cell death by modulation of mitochondrial and death receptor apoptotic pathways.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874079

The pediatric preclinical testing program: description of models and early testing results.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874079

STK15 polymorphisms and association with risk of invasive ovarian cancer.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874079

Characterization of childhood acute lymphoblastic leukemia xenograft models for the preclinical evaluation of new therapies

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874079

Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874079

A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874079

Amplification/overexpression of a mitotic kinase gene in human bladder cancer

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20108338

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

STK15 polymorphism and breast cancer risk in a population-based study

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20108338

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/PBC.22430

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20108338%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

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17 January 2020

PubMed publication ID

20108338

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20108338%20AND%20SRC:MED&resulttype=core&format=json