Development of TRPM8 Antagonists to Treat Chronic Pain and Migraine (Q33851503)

29 July 2017

title

Development of TRPM8 Antagonists to Treat Chronic Pain and Migraine (English)

1 reference

29 July 2017

0 references

1 reference

Andy D Weyer

0 references

Sonya G Lehto

1 reference

29 July 2017

language of work or name

1 reference

30 March 2017

1 reference

29 July 2017

1 reference

29 July 2017

1 reference

29 July 2017

1 reference

Creative Commons Attribution 4.0 International

29 July 2017

start time

30 March 2017

1 reference

April 2022 Public Data File from Crossref

copyrighted

0 references

cites work

Transient Receptor Potential Channels in neuropathic pain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

Gene-based pleiotropy across migraine with aura and migraine without aura patient groups

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

Meningeal transient receptor potential channel M8 activation causes cutaneous facial and hindpaw allodynia in a preclinical rodent model of headache

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

Discovery of a Selective TRPM8 Antagonist with Clinical Efficacy in Cold-Related Pain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

AMG2850, a potent and selective TRPM8 antagonist, is not effective in rat models of inflammatory mechanical hypersensitivity and neuropathic tactile allodynia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

Antibodies to the extracellular pore loop of TRPM8 act as antagonists of channel activation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

Targeting TRP channels for novel migraine therapeutics

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

Selectivity in genetic association with sub-classified migraine in women

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

Replication of migraine GWAS susceptibility loci in Chinese Han population

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

Optimization of potency and pharmacokinetic properties of tetrahydroisoquinoline transient receptor potential melastatin 8 (TRPM8) antagonists

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

Transient receptor potential melastatin 8 channel inhibition potentiates the hypothermic response to transient receptor potential vanilloid 1 activation in the conscious mouse

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

TRPM8 activation attenuates inflammatory responses in mouse models of colitis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

A sensory-labeled line for cold: TRPM8-expressing sensory neurons define the cellular basis for cold, cold pain, and cooling-mediated analgesia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

Peripheral neuropathies from chemotherapeutics and targeted agents: diagnosis, treatment, and prevention

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

Expression of the transient receptor potential channels TRPV1, TRPA1 and TRPM8 in mouse trigeminal primary afferent neurons innervating the dura

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

TRP channels and analgesia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

Genome-wide association analysis identifies susceptibility loci for migraine without aura

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

Transient receptor potential melastatin 8 (TRPM8) channels are involved in body temperature regulation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

The design and synthesis of novel, phosphonate-containing transient receptor potential melastatin 8 (TRPM8) antagonists

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

Menthol pain relief through cumulative inactivation of voltage-gated sodium channels

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

Role of TRPM8 in dorsal root ganglion in nerve injury-induced chronic pain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

Pharmacological blockade of TRPM8 ion channels alters cold and cold pain responses in mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

Chemotherapy-induced peripheral neuropathy: prevention and treatment

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

Prevalence of symptoms of bladder pain syndrome/interstitial cystitis among adult females in the United States

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

Therapeutic targeting of TRP channels--the TR(i)P to pain relief

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

TRPM8 biology and medicinal chemistry

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

Genome-wide association study reveals three susceptibility loci for common migraine in the general population

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

Design and Optimization of Benzimidazole-Containing Transient Receptor Potential Melastatin 8 (TRPM8) Antagonists

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): somatosensory abnormalities in 1236 patients with different neuropathic pain syndromes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

Warm and cold complex regional pain syndromes: differences beyond skin temperature?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

AMTB, a TRPM8 channel blocker: evidence in rats for activity in overactive bladder and painful bladder syndrome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

Chemotherapy-induced neuropathy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

Increased TRPA1, TRPM8, and TRPV2 expression in dorsal root ganglia by nerve injury

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

TRPM8 is required for cold sensation in mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

Cool and menthol receptor TRPM8 in human urinary bladder disorders and clinical correlations

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

TRPA1 and TRPM8 activation in humans: effects of cinnamaldehyde and menthol

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

TRPM8 activation by menthol, icilin, and cold is differentially modulated by intracellular pH.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

Topical menthol--a human model for cold pain by activation and sensitization of C nociceptors.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

A novel treatment of postherpetic neuralgia using peppermint oil.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

A TRP channel that senses cold stimuli and menthol

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

Identification of a cold receptor reveals a general role for TRP channels in thermosensation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

Menthol and related cooling compounds

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490394

Bimodal action of menthol on the transient receptor potential channel TRPA1.

5 July 2018

1 reference

https://api.crossref.org/works/10.3390%2FPH10020037

Central mechanisms of menthol-induced analgesia

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FPH10020037

Allyl isothiocyanate sensitizes TRPV1 to heat stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FPH10020037

Downregulation of transient receptor potential melastatin 8 by protein kinase C-mediated dephosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FPH10020037

From bench to bedside: a case of rapid reversal of bortezomib-induced neuropathic pain by the TRPM8 activator, menthol

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FPH10020037

Thermal hyperalgesia as a marker of oxaliplatin neurotoxicity: a prospective quantified sensory assessment study.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FPH10020037

Pain in oxaliplatin-induced neuropathy--sensitisation in the peripheral and central nociceptive system.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FPH10020037

Involvement of increased expression of transient receptor potential melastatin 8 in oxaliplatin-induced cold allodynia in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FPH10020037

TRPM8 mechanism of cold allodynia after chronic nerve injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FPH10020037

Inhibition of TRPM8 channels reduces pain in the cold pressor test in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FPH10020037

Sex differences in the expression profile of acid-sensing ion channels in the mouse urinary bladder: a possible involvement in irritative bladder symptoms.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FPH10020037

Functional role of the transient receptor potential melastatin 8 (TRPM8) ion channel in the urinary bladder assessed by conscious cystometry and ex vivo measurements of single-unit mechanosensitive bladder afferent activities in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FPH10020037

Replication and meta-analysis of common variants identifies a genome-wide significant locus in migraine.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FPH10020037

SNP variants within the vanilloid TRPV1 and TRPV3 receptor genes are associated with migraine in the Spanish population.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FPH10020037

PRDM16 rs2651899 variant is a risk factor for Chinese common migraine patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FPH10020037

Genome-wide-associated variants in migraine susceptibility: a replication study from North India

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FPH10020037

Psychophysical study of the effects of topical application of menthol in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FPH10020037

Synthesis and pharmacological evaluation of novel N-aryl-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamides as TRPM8 antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FPH10020037

Fused piperidines as a novel class of potent and orally available transient receptor potential melastatin type 8 (TRPM8) antagonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FPH10020037

High-Concentration L-Menthol Exhibits Counter-Irritancy to Neurogenic Inflammation, Thermal and Mechanical Hyperalgesia Caused by Trans-cinnamaldehyde

21 January 2018

1 reference

12 December 2020

Expression of the TRPM8-immunoreactivity in dorsal root ganglion neurons innervating the rat urinary bladder

1 reference

12 December 2020

Replication study of previous migraine genome-wide association study findings in a Spanish sample of migraine with aura

1 reference

12 December 2020

Discovery of vinylcycloalkyl-substituted benzimidazole TRPM8 antagonists effective in the treatment of cold allodynia

1 reference

12 December 2020

Identification of a novel 2-pyridyl-benzensulfonamide derivative, RQ-00203078, as a selective and orally active TRPM8 antagonist

1 reference

12 December 2020

Arylglycine derivatives as potent transient receptor potential melastatin 8 (TRPM8) antagonists

1 reference

12 December 2020

Identifiers

DOI

10.3390/PH10020037

1 reference

29 July 2017

1 reference

29 July 2017

1 reference