Cellular mechanisms of tissue fibrosis. 8. Current and future drug targets in fibrosis: focus on Rho GTPase-regulated gene transcription. (Q33840143)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24740541%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

title

Cellular mechanisms of tissue fibrosis. 8. Current and future drug targets in fibrosis: focus on Rho GTPase-regulated gene transcription (English)

1 reference

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14 March 2020

1 reference

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14 March 2020

Pei-Suen Tsou

1 reference

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14 March 2020

Andrew J Haak

series ordinal

1 reference

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14 March 2020

Dinesh Khanna

series ordinal

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publication date

16 April 2014

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American Journal of Physiology - Cell Physiology

14 March 2020

published in

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14 March 2020

volume

307

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14 March 2020

issue

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14 March 2020

page(s)

C2-13

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Targeting the myofibroblast genetic switch: inhibitors of myocardin-related transcription factor/serum response factor-regulated gene transcription prevent fibrosis in a murine model of skin injury

14 March 2020

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5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080186

Rho GTPases in cell biology

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080186

Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080186

Matrix metalloproteinases cleave connective tissue growth factor and reactivate angiogenic activity of vascular endothelial growth factor 165

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080186

TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080186

The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080186

Deficient Smad7 expression: a putative molecular defect in scleroderma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080186

TGF-beta1 mediates the hypertrophic cardiomyocyte growth induced by angiotensin II.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080186

The integrin alphaVbeta6 binds and activates latent TGFbeta3.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080186

The low density lipoprotein receptor-related protein/alpha2-macroglobulin receptor is a receptor for connective tissue growth factor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080186

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080186

Reversal of cardiac and renal fibrosis by pirfenidone and spironolactone in streptozotocin-diabetic rats

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080186

The activity of guanine exchange factor NET1 is essential for transforming growth factor-beta-mediated stress fiber formation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080186

Lysophosphatidic acid receptors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080186

Smooth muscle differentiation marker gene expression is regulated by RhoA-mediated actin polymerization

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080186

Functional coupling of G proteins to endothelin receptors is ligand and receptor subtype specific

5 July 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080186

5 July 2018

https://api.crossref.org/works/10.1152%2FAJPCELL.00060.2014

Activation of latent TGF-beta by thrombospondin-1: mechanisms and physiology

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080186

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080186

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080186

Effects of pirfenidone on transforming growth factor-beta gene expression at the transcriptional level in bleomycin hamster model of lung fibrosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080186

Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: A mouse fibrosis model

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080186

Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080186

A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080186

Fisp12/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin alphavbeta3, promotes endothelial cell survival, and induces angiogenesis in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080186

The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080186

A single receptor encoded by vzg-1/lpA1/edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080186

Highlights on endothelins: a review

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080186

Endothelin antagonism in experimental hepatic fibrosis. Implications for endothelin in the pathogenesis of wound healing

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080186

Involvement of the small GTPase rho in integrin-mediated activation of mitogen-activated protein kinase.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080186

The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080186

Increased endothelin-1 production in fibroblasts derived from patients with systemic sclerosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080186

Endothelin-1 in idiopathic pulmonary fibrosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080186

Growth inhibitory properties of endothelin-1 in human hepatic myofibroblastic Ito cells. An endothelin B receptor-mediated pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080186

Dietary intake of pirfenidone ameliorates bleomycin-induced lung fibrosis in hamsters

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080186

A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080186

Rho-associated kinases are crucial for myofibroblast differentiation and production of extracellular matrix in scleroderma fibroblasts

5 July 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00060.2014

Increased expression of integrin alpha(v)beta3 contributes to the establishment of autocrine TGF-beta signaling in scleroderma fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00060.2014

Amelioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00060.2014

Induction of an epithelial to mesenchymal transition in human immortal and malignant keratinocytes by TGF-beta1 involves MAPK, Smad and AP-1 signalling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00060.2014

Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00060.2014

Profibrotic effects of endothelin-1 via the ETA receptor in cultured human cardiac fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00060.2014

Anti-vascular endothelial growth factor gene therapy attenuates lung injury and fibrosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00060.2014

Molecular mechanism for endothelin-1-induced stress-fiber formation: analysis of G proteins using a mutant endothelin(A) receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00060.2014

BUILD-1: a randomized placebo-controlled trial of bosentan in idiopathic pulmonary fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00060.2014

Endothelin 1 contributes to the effect of transforming growth factor beta1 on wound repair and skin fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00060.2014

Connective tissue growth factor: a crucial cytokine-mediating cardiac fibrosis in ongoing enterovirus myocarditis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00060.2014

Targeted disruption of Smad3 confers resistance to the development of dimethylnitrosamine-induced hepatic fibrosis in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00060.2014

Disruption of Smad4 impairs TGF-β/Smad3 and Smad7 transcriptional regulation during renal inflammation and fibrosis in vivo and in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00060.2014

Transforming growth factor-beta receptor type I-dependent fibrogenic gene program is mediated via activation of Smad1 and ERK1/2 pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00060.2014

LPA1 receptor activation promotes renal interstitial fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00060.2014

Imatinib mesylate in scleroderma-associated diffuse skin fibrosis: a phase II multicentre randomized double-blinded controlled trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00060.2014

Different expression of endothelin in the bronchoalveolar lavage in patients with pulmonary diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00060.2014

Comparing the differential effects of LPA on the barrier function of human pulmonary endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00060.2014

Elevated expression of endothelin-1 and endothelin-converting enzyme-1 in idiopathic pulmonary fibrosis: possible involvement of proinflammatory cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00060.2014

Critical role of serum response factor in pulmonary myofibroblast differentiation induced by TGF-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00060.2014

The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00060.2014

Down-regulation of connective tissue growth factor and type I collagen mRNA expression by connective tissue growth factor antisense oligonucleotide during experimental liver fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00060.2014

Endothelial cell-derived endothelin-1 promotes cardiac fibrosis in diabetic hearts through stimulation of endothelial-to-mesenchymal transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00060.2014

Lysophosphatidic acid induces alphavbeta6 integrin-mediated TGF-beta activation via the LPA2 receptor and the small G protein G alpha(q).

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00060.2014

Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-beta and mediates TIMP-1 up-regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00060.2014

Involvement of serum response factor isoforms in myofibroblast differentiation during bleomycin-induced lung injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00060.2014

Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00060.2014

Upregulated expression of transforming growth factor-beta receptors in dermal fibroblasts of skin sections from patients with systemic sclerosis.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080186

Pulmonary Fibrosis and Chronic Lung Inflammation in ET-1 Transgenic Mice

29 October 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00060.2014

Connective Tissue Growth Factor Expressed in Tubular Epithelium Plays a Pivotal Role in Renal Fibrogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00060.2014

Functional cooperation between Smad proteins and activator protein-1 regulates transforming growth factor-beta-mediated induction of endothelin-1 expression

21 January 2018

1 reference

12 December 2020

Dissecting the roles of endothelin, TGF-beta and GM-CSF on myofibroblast differentiation by keratinocytes

1 reference

12 December 2020

Significance of plasma endothelin-1 levels in patients with systemic sclerosis

1 reference

12 December 2020

1 reference

12 December 2020

Both Plasma Lysophosphatidic Acid and Serum Autotaxin Levels are Increased in Chronic Hepatitis C

1 reference

12 December 2020

Plasma lysophosphatidic acid level and serum autotaxin activity are increased in liver injury in rats in relation to its severity

1 reference

12 December 2020

Loss of beta1 integrin in mouse fibroblasts results in resistance to skin scleroderma in a mouse model

1 reference

12 December 2020

Altered dynamics of transforming growth factor (TGF- ) receptors in scleroderma fibroblasts

1 reference

12 December 2020

Human antitransforming growth factor beta(2) monoclonal antibody--a new modulator of wound healing in trabeculectomy: a randomized placebo controlled clinical study

1 reference

12 December 2020

Statin-Mediated Inhibition of Rho

1 reference

12 December 2020

Topical application of a peptide inhibitor of transforming growth factor-beta1 ameliorates bleomycin-induced skin fibrosis

1 reference

12 December 2020

Transforming growth factor-beta activation of phosphatidylinositol 3-kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21-activated kinase-2

1 reference

12 December 2020

Signalling and regulation of collagen I synthesis by ET-1 and TGF-beta1

1 reference

12 December 2020

Recombinant human anti–transforming growth factor β1 antibody therapy in systemic sclerosis: A multicenter, randomized, placebo-controlled phase I/II trial of CAT-192

1 reference

12 December 2020

Evaluation of clinical efficacy of fasudil for the treatment of pulmonary arterial hypertension

1 reference

12 December 2020

Pulmonary autotaxin expression contributes to the pathogenesis of pulmonary fibrosis

1 reference

12 December 2020

Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription

1 reference

12 December 2020

Antiproliferative effects of ET-1 in human liver Ito cells: an ETB- and a cyclic AMP-mediated pathway

1 reference

12 December 2020

10.1152/AJPCELL.00060.2014

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24740541%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24740541%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

PubMed publication ID

24740541

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24740541%20AND%20SRC:MED&resulttype=core&format=json