Inhibitory G proteins and their receptors: emerging therapeutic targets for obesity and diabetes (Q33844872)

29 July 2017

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Inhibitory G proteins and their receptors: emerging therapeutic targets for obesity and diabetes (English)

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29 July 2017

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cell surface receptor

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physiological phenomenon

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Michelle E Kimple

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Joshua C Neuman

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Amelia K Linnemann

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Patrick J Casey

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language of work or name

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Experimental and Molecular Medicine

29 July 2017

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Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

29 July 2017

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on focus list of Wikimedia project

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ScienceSource

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Comparison of efficacy between incretin-based therapies for type 2 diabetes mellitus

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Omega-3 fatty acids and incident type 2 diabetes: a systematic review and meta-analysis

5 July 2018

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Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes

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Deletion of GαZ protein protects against diet-induced glucose intolerance via expansion of β-cell mass

5 July 2018

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Distinct β-cell defects in impaired fasting glucose and impaired glucose tolerance

5 July 2018

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Eicosanoids, β-cell function, and diabetes

5 July 2018

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Regulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets

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Incretin effects on β-cell function, replication, and mass: the human perspective

5 July 2018

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Variants of ADRA2A are associated with fasting glucose, blood pressure, body mass index and type 2 diabetes risk: meta-analysis of four prospective studies

5 July 2018

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Incretin physiology beyond glucagon‐like peptide 1 and glucose‐dependent insulinotropic polypeptide: cholecystokinin and gastrin peptides

5 July 2018

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High Pancreatic n-3 Fatty Acids Prevent STZ-Induced Diabetes in Fat-1 Mice: Inflammatory Pathway Inhibition

5 July 2018

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Genetic variations in the α(2A)-adrenoreceptor are associated with blood pressure response to the agonist dexmedetomidine

5 July 2018

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Augmented glucose-induced insulin release in mice lacking G(o2), but not G(o1) or G(i) proteins

5 July 2018

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A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents

5 July 2018

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Noradrenaline inhibits exocytosis via the G protein βγ subunit and refilling of the readily releasable granule pool via the α(i1/2) subunit

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5 July 2018

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5 July 2018

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Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes

5 July 2018

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Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death

5 July 2018

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5 July 2018

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Inhibition of heterotrimeric G protein signaling by a small molecule acting on Galpha subunit

5 July 2018

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Melatonin receptors in pancreatic islets: good morning to a novel type 2 diabetes gene

5 July 2018

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Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes

5 July 2018

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Insulin signaling in alpha cells modulates glucagon secretion in vivo

5 July 2018

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5 July 2018

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Mechanisms of biphasic insulin-granule exocytosis - roles of the cytoskeleton, small GTPases and SNARE proteins

5 July 2018

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Synthesis and characterization of a peripherally restricted CB1 cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice

5 July 2018

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A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk

5 July 2018

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Variants in MTNR1B influence fasting glucose levels

5 July 2018

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The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases

5 July 2018

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Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes

5 July 2018

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Diabetes, colorectal cancer and cyclooxygenase 2 inhibition

5 July 2018

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Islet inflammation in type 2 diabetes: from metabolic stress to therapy.

5 July 2018

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Galphaz negatively regulates insulin secretion and glucose clearance

5 July 2018

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Melatonin, endocrine pancreas and diabetes.

5 July 2018

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G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes.

5 July 2018

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Effect of selective cyclooxygenase-2 (COX-2) inhibitor treatment on glucose-stimulated insulin secretion in C57BL/6 mice

5 July 2018

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Mechanisms of obesity-associated insulin resistance: many choices on the menu

5 July 2018

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New therapeutic strategies for the treatment of type 2 diabetes mellitus based on incretins

5 July 2018

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Night eating and obesity in the EP3R-deficient mouse

5 July 2018

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Abdominal obesity and metabolic syndrome

5 July 2018

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From mice to men: insights into the insulin resistance syndromes

5 July 2018

1 reference

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Therapeutic approaches to preserve islet mass in type 2 diabetes

5 July 2018

1 reference

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A role for G(z) in pancreatic islet beta-cell biology

5 July 2018

1 reference

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Targeting beta-cell cyclic 3'5' adenosine monophosphate for the development of novel drugs for treating type 2 diabetes mellitus. A review

5 July 2018

1 reference

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Transcriptional regulation of cyclooxygenase-2 gene in pancreatic beta-cells

5 July 2018

1 reference

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Global prevalence of diabetes: estimates for the year 2000 and projections for 2030

5 July 2018

1 reference

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Glucose-induced regulation of COX-2 expression in human islets of Langerhans

5 July 2018

1 reference

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Contributions of insulin-resistance and insulin-secretory defects to the pathogenesis of type 2 diabetes mellitus

5 July 2018

1 reference

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The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes

5 July 2018

1 reference

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Pharmacological agents that directly modulate insulin secretion

5 July 2018

1 reference

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G(z) signaling: emerging divergence from G(i) signaling

5 July 2018

1 reference

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Fatty acids and immune responses--a new perspective in searching for clues to mechanism

5 July 2018

1 reference

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Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle

5 July 2018

1 reference

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New insights into sympathetic regulation of glucose and fat metabolism

5 July 2018

1 reference

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G proteins as drug targets

5 July 2018

1 reference

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Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion

5 July 2018

1 reference

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Type 2 diabetes care: the role of insulin-sensitizing agents and practical implications for cardiovascular disease prevention

5 July 2018

1 reference

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Basal expression of cyclooxygenase-2 and nuclear factor-interleukin 6 are dominant and coordinately regulated by interleukin 1 in the pancreatic islet

5 July 2018

1 reference

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G alpha(o) is necessary for muscarinic regulation of Ca2+ channels in mouse heart

5 July 2018

1 reference

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Insulin action impaired by deficiency of the G-protein subunit G ialpha2

5 July 2018

1 reference

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Hypothesis: prostaglandins mediate defective glucose recognition in diabetes mellitus

5 July 2018

1 reference

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Abnormal alpha-adrenergic mechanisms in diabetes mellitus.

5 July 2018

1 reference

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Eicosanoids as pluripotential modulators of pancreatic islet function

5 July 2018

1 reference

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Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081554

Sequence analysis of cDNA and genomic DNA for a putative pertussis toxin-insensitive guanine nucleotide-binding regulatory protein alpha subunit

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081554

Activation of alpha 2-adrenergic receptors decreases Ca2+ influx to inhibit insulin secretion in a hamster beta-cell line: an action mediated by a guanosine triphosphate-binding protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081554

Analysis by mRNA levels of the expression of six G protein alpha-subunit genes in mammalian cells and tissues

5 July 2018

1 reference

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Pathogenesis of type 2 (non-insulin dependent) diabetes mellitus: a balanced overview

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081554

A role for alpha-adrenergic receptors in abnormal insulin secretion in diabetes mellitus

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081554

A Role for Prostaglandin E in Defective Insulin Secretion and Carbohydrate Intolerance in Diabetes Mellitus

5 July 2018

1 reference

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Islet-activating protein. Enhanced insulin secretion and cyclic AMP accumulation in pancreatic islets due to activation of native calcium ionophores

5 July 2018

1 reference

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Blocking the EP3 receptor for PGE2 with DG-041 decreases thrombosis without impairing haemostatic competence.

5 July 2018

1 reference

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Role of reduced β-cell mass versus impaired β-cell function in the pathogenesis of type 2 diabetes

29 October 2018

1 reference

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Association of risk variants for type 2 diabetes and hyperglycemia with gestational diabetes

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081554

Melatonin acts through MT1/MT2 receptors to activate hypothalamic Akt and suppress hepatic gluconeogenesis in rats.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081554

Melatonin improves insulin sensitivity independently of weight loss in old obese rats.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081554

Surgical treatments for obesity

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081554

Impaired regulation of the incretin effect in patients with type 2 diabetes

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081554

Increased expression of cyclooxygenase-2 in human pancreatic islets treated with high glucose or ligands of the advanced glycation endproduct-specific receptor (AGER), and in islets from diabetic mice

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081554

American Diabetes Association position statement: evidence-based nutrition principles and recommendations for the treatment and prevention of diabetes and related complications

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081554

Galpha i2 enhances in vivo activation of and insulin signaling to GLUT4.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081554

Metformin reduces weight, centripetal obesity, insulin, leptin, and low-density lipoprotein cholesterol in nondiabetic, morbidly obese subjects with body mass index greater than 30.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081554

Epidemiology of type 2 diabetes: risk factors

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081554

PGE2, via EP3 receptors, regulates brain nitric oxide synthase in the perinatal period.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081554

The genetic basis of type 2 diabetes mellitus: impaired insulin secretion versus impaired insulin sensitivity.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081554

Metformin decreases food consumption and induces weight loss in subjects with obesity with type II non-insulin-dependent diabetes

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081554

CSF levels of prostaglandins, especially the level of prostaglandin D2, are correlated with increasing propensity towards sleep in rats

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081554

Gz, a guanine nucleotide-binding protein with unique biochemical properties.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081554

Cannabinoid-1 Receptor Antagonist, Rimonabant, for Management of Obesity and Related Risks

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081554

Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: a randomised controlled study

29 October 2018

1 reference

12 December 2020

1 reference

12 December 2020

The long-term response of diabetes mellitus to salicylate therapy: report of a case

1 reference

12 December 2020

Conditional, tissue-specific expression of Q205L G alpha i2 in vivo mimics insulin action

1 reference

12 December 2020

Diabetes: Should we treat infection or inflammation to prevent T2DM?

1 reference

12 December 2020

Comparing the efficacy and safety profile of sitagliptin versus glimepiride in patients of type 2 diabetes mellitus inadequately controlled with metformin alone

1 reference

12 December 2020

Reduced incretin effect in type 2 (non-insulin-dependent) diabetes

1 reference

12 December 2020

Dominance of cyclooxygenase-2 in the regulation of pancreatic islet prostaglandin synthesis

1 reference

12 December 2020

Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction

1 reference

12 December 2020

Identifiers

DOI

10.1038/EMM.2014.40

1 reference

Dimensions Publication ID

29 July 2017

0 references

1 reference

29 July 2017

1 reference