Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applications (Q33844511)

29 July 2017

title

Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applications (English)

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29 July 2017

John R Engen

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Hui Wei

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29 July 2017

Jingjie Mo

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29 July 2017

Li Tao

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29 July 2017

Reb J Russell

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29 July 2017

Adrienne A Tymiak

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29 July 2017

Guodong Chen

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29 July 2017

Roxana E Iacob

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29 July 2017

publication date

6 August 2013

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29 July 2017

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29 July 2017

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29 July 2017

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29 July 2017

page(s)

95-102

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Dissecting the energetics of an antibody-antigen interface by alanine shaving and molecular grafting

5 July 2018

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5 July 2018

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Conformational changes in proteins probed by hydrogen-exchange electrospray-ionization mass spectrometry

5 July 2018

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Protein folding studied using hydrogen-exchange labeling and two-dimensional NMR

5 July 2018

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5 July 2018

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Effect of covalent attachment of polyethylene glycol on immunogenicity and circulating life of bovine liver catalase

5 July 2018

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Fluoroketone inhibition of Ca(2+)-independent phospholipase A2 through binding pocket association defined by hydrogen/deuterium exchange and molecular dynamics

5 July 2018

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29 October 2018

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29 October 2018

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Mapping of discontinuous conformational epitopes by amide hydrogen/deuterium exchange mass spectrometry and computational docking.

29 October 2018

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29 October 2018

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Analysis of protein complexes with hydrogen exchange and mass spectrometry.

29 October 2018

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High resolution functional analysis of antibody-antigen interactions

29 October 2018

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12 December 2020

Effect of antibody binding on protein motions studied by hydrogen-exchange labeling and two-dimensional NMR

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Comparison of continuous and pulsed labeling amide hydrogen exchange/mass spectrometry for studies of protein dynamics

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12 December 2020

Exchange of hydrogen atoms in insulin with deuterium atoms in aqueous solutions

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12 December 2020

The kinetics of the deuterium exchange of insulin with D2O. An amendment

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12 December 2020

Use of hydrogen/deuterium exchange mass spectrometry and mutagenesis as a tool to identify the binding region of inhibitors targeting the human mitotic kinesin Eg5

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12 December 2020

Pulsed hydrogen/deuterium exchange MS/MS for studying the relationship between noncovalent protein complexes in solution and in the gas phase after electrospray ionization

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A Role for Protein Misfolding in Immunogenicity of Biopharmaceuticals

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Epitope mapping by amide hydrogen/deuterium exchange coupled with immobilization of antibody, on-line proteolysis, liquid chromatography and mass spectrometry

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10.1016/J.DRUDIS.2013.07.019

Identifiers

DOI

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29 July 2017

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29 July 2017

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