Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity (Q33832643)

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English	Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

29 July 2017

Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity (English)

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Europe PubMed Central

PubMed publication ID

29 July 2017

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Markus Zweckstetter

5

object named as

Markus Zweckstetter

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7

object named as

Hilal A Lashuel

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Europe PubMed Central

PubMed publication ID

29 July 2017

Pierre-Alain Carrupt

6

object named as

Pierre-Alain Carrupt

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Europe PubMed Central

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29 July 2017

author name string

Saviana Di Giovanni

1

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Europe PubMed Central

PubMed publication ID

29 July 2017

Simona Eleuteri

2

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Europe PubMed Central

PubMed publication ID

29 July 2017

Katerina E Paleologou

3

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Europe PubMed Central

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29 July 2017

Guowei Yin

4

1 reference

Europe PubMed Central

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29 July 2017

Markus Zweckstetter

5

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29 July 2017

language of work or name

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publication date

11 February 2010

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Europe PubMed Central

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29 July 2017

Journal of Biological Chemistry

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29 July 2017

285

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Europe PubMed Central

PubMed publication ID

29 July 2017

20

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

14941-14954

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

1 reference

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28 July 2018

Structure and function of the molecular chaperone Hsp104 from yeast

1 reference

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28 July 2018

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein

1 reference

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28 July 2018

Tolcapone: review of its pharmacology and use as adjunctive therapy in patients with Parkinson's disease

1 reference

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28 July 2018

Consumption of grape seed extract prevents amyloid-beta deposition and attenuates inflammation in brain of an Alzheimer's disease mouse

1 reference

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28 July 2018

alpha-Synuclein and neuronal cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865316

28 July 2018

What's in the pipeline for the treatment of Parkinson's disease?

1 reference

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28 July 2018

Inhibition of alpha-synuclein fibrillization by dopamine is mediated by interactions with five C-terminal residues and with E83 in the NAC region

1 reference

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28 July 2018

C-terminal peptides coassemble into Abeta42 oligomers and protect neurons against Abeta42-induced neurotoxicity

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28 July 2018

COMT inhibition with tolcapone in the treatment algorithm of patients with Parkinson's disease (PD): relevance for motor and non-motor features

1 reference

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28 July 2018

Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease

1 reference

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28 July 2018

The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity

1 reference

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28 July 2018

Protective effect of quercetin in primary neurons against Abeta(1-42): relevance to Alzheimer's disease

1 reference

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28 July 2018

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

1 reference

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28 July 2018

Clearance and deposition of extracellular alpha-synuclein aggregates in microglia.

1 reference

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28 July 2018

Assembly-dependent endocytosis and clearance of extracellular alpha-synuclein.

1 reference

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28 July 2018

Neuroprotective properties of gallic acid from Sanguisorbae radix on amyloid beta protein (25--35)-induced toxicity in cultured rat cortical neurons

1 reference

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28 July 2018

Catechol-O-methyltransferase and its inhibitors in Parkinson's disease

1 reference

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28 July 2018

Alpha-synuclein activates stress signaling protein kinases in THP-1 cells and microglia

1 reference

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28 July 2018

Safety and tolerability of adjunctive tolcapone treatment in patients with early Parkinson's disease

1 reference

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28 July 2018

Bioactivation and hepatotoxicity of nitroaromatic drugs

1 reference

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28 July 2018

A century-old debate on protein aggregation and neurodegeneration enters the clinic

1 reference

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28 July 2018

Plant phenolics behave as radical scavengers in the context of insect (Manduca sexta) hemolymph and midgut fluid

1 reference

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28 July 2018

Release of long-range tertiary interactions potentiates aggregation of natively unstructured alpha-synuclein

1 reference

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28 July 2018

Structure and function of amyloid in Alzheimer's disease

1 reference

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28 July 2018

Synthesis, biological evaluation, and molecular modeling studies of a novel, peripherally selective inhibitor of catechol-O-methyltransferase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865316

28 July 2018

Protective effect of TAT-delivered alpha-synuclein: relevance of the C-terminal domain and involvement of HSP70.

1 reference

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28 July 2018

NMR of alpha-synuclein-polyamine complexes elucidates the mechanism and kinetics of induced aggregation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865316

28 July 2018

Phthalocyanine tetrasulfonates affect the amyloid formation and cytotoxicity of alpha-synuclein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865316

28 July 2018

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865316

28 July 2018

New insights into Parkinson?s disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865316

28 July 2018

Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

1 reference

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28 July 2018

Protein aggregation in disease: a role for folding intermediates forming specific multimeric interactions

1 reference

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28 July 2018

New Class of Inhibitors of Amyloid-beta Fibril Formation. IMPLICATIONS FOR THE MECHANISM OF PATHOGENESIS IN ALZHEIMER'S DISEASE

1 reference

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28 July 2018

Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865316

28 July 2018

Effect of familial Parkinson's disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human alpha-synuclein

1 reference

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28 July 2018

Induction of neuronal cell death by Rab5A-dependent endocytosis of alpha-synuclein

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28 July 2018

Accelerated oligomerization by Parkinson's disease linked alpha-synuclein mutants

1 reference

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28 July 2018

Alpha-synuclein and Parkinson's disease: selective neurodegenerative effect of alpha-synuclein fragment on dopaminergic neurons in vitro and in vivo

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28 July 2018

Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid

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28 July 2018

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

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28 July 2018

α-Synuclein in Lewy bodies

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28 July 2018

Models of amyloid seeding in Alzheimer's disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins

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28 July 2018

How to measure and predict the molar absorption coefficient of a protein

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Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

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28 July 2018

Biochemical and pharmacological properties of a peripherally acting catechol-O-methyltransferase inhibitor entacapone

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28 July 2018

Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease

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21 January 2018

Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein.

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21 January 2018

High resolution scanning tunnelling microscopy of the beta-amyloid protein (Abeta1-40) of Alzheimer's disease suggests a novel mechanism of oligomer assembly.

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21 January 2018

Dopamine promotes alpha-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway

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21 January 2018

Inhibition of alpha-synuclein fibrillization by dopamine analogs via reaction with the amino groups of alpha-synuclein. Implication for dopaminergic neurodegeneration

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21 January 2018

Reversible inhibition of alpha-synuclein fibrillization by dopaminochrome-mediated conformational alterations.

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21 January 2018

The flavonoid baicalein inhibits fibrillation of alpha-synuclein and disaggregates existing fibrils

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21 January 2018

Dopamine and L-dopa disaggregate amyloid fibrils: implications for Parkinson's and Alzheimer's disease

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21 January 2018

Anti-fibrillogenic and fibril-destabilizing activities of anti-Parkinsonian agents for alpha-synuclein fibrils in vitro

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21 January 2018

Antiproliferative and apoptosis-inducing activities of alkyl gallate and gallamide derivatives related to (-)-epigallocatechin gallate

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21 January 2018

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21 January 2018

Insulin-like growth factor I protects and rescues hippocampal neurons against beta-amyloid- and human amylin-induced toxicity.

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21 January 2018

Assembly of A beta amyloid protofibrils: an in vitro model for a possible early event in Alzheimer's disease

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21 January 2018

Atomic force microscopic imaging of seeded fibril formation and fibril branching by the Alzheimer's disease amyloid-beta protein

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21 January 2018

Neuroprotective effects of green and black teas and their catechin gallate esters against beta-amyloid-induced toxicity

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21 January 2018

Protective effect of caffeic acid against beta-amyloid-induced neurotoxicity by the inhibition of calcium influx and tau phosphorylation

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21 January 2018

Inositol stereoisomers stabilize an oligomeric aggregate of Alzheimer amyloid beta peptide and inhibit abeta -induced toxicity.

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21 January 2018

Resveratrol inhibits beta-amyloid oligomeric cytotoxicity but does not prevent oligomer formation

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21 January 2018

Nucleation-dependent polymerization is an essential component of amyloid-mediated neuronal cell death.

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21 January 2018

Forcing nonamyloidogenic beta-synuclein to fibrillate

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21 January 2018

Decreased alpha-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson's disease

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21 January 2018

Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease

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21 January 2018

A peptide motif consisting of glycine, alanine, and valine is required for the fibrillization and cytotoxicity of human alpha-synuclein

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21 January 2018

Amino acid sequence motifs and mechanistic features of the membrane translocation of alpha-synuclein

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21 January 2018

Tolcapone enhances food-evoked dopamine efflux and executive memory processes mediated by the rat prefrontal cortex

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21 January 2018

The Lipophilicity Behavior of Three Catechol-O-methyltransferase (COMT) Inhibitors and Simple Analogues

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21 January 2018

Pharmacokinetics and pharmacodynamics of entacapone and tolcapone after acute and repeated administration: a comparative study in the rat

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21 January 2018

31P-MRS of skeletal muscle is not a sensitive diagnostic test for mitochondrial myopathy

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21 January 2018

Levodopa/DDCI and entacapone is the preferred treatment for Parkinson's disease patients with motor fluctuations in routine practice: a retrospective, observational analysis of a large French cohort

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21 January 2018

Alpha-synuclein regulates neuronal survival via Bcl-2 family expression and PI3/Akt kinase pathway

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21 January 2018

Pyrogallol as a glutathione depletor induces apoptosis in HeLa cells.

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29 October 2018

First-order kinetic model of Alzheimer's beta-amyloid fibril extension in vitro.

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29 October 2018

Studies of protein-ligand interactions by NMR

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10 December 2018

Mutation screening in exons 3 and 4 of alpha-synuclein in sporadic Parkinson's and sporadic and familial dementia with Lewy bodies cases

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New drug delivery strategies for improved Parkinson's disease therapy

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Alpha-synuclein and Parkinson's disease

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Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease

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12 December 2020

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Novel screening assay for antioxidant protection against peroxyl radical-induced loss of protein function

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Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments

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12 December 2020

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Tolcapone and fulminant hepatitis

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Identifiers

10.1074/JBC.M109.080390

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

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