IL-7 and IL-21 are superior to IL-2 and IL-15 in promoting human T cell-mediated rejection of systemic lymphoma in immunodeficient mice (Q33839836)

29 July 2017

title

IL-7 and IL-21 are superior to IL-2 and IL-15 in promoting human T cell-mediated rejection of systemic lymphoma in immunodeficient mice (English)

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29 July 2017

John C Markley

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29 July 2017

Michel Sadelain

series ordinal

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29 July 2017

language of work or name

English

0 references

publication date

26 February 2010

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29 July 2017

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29 July 2017

volume

115

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29 July 2017

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29 July 2017

page(s)

3508-3519

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Genetic modification of T cells with IL-21 enhances antigen presentation and generation of central memory tumor-specific cytotoxic T-lymphocytes

29 July 2017

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5 July 2018

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Self-antigen-specific CD8+ T cell precursor frequency determines the quality of the antitumor immune response.

5 July 2018

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Genetic manipulation of tumor-specific cytotoxic T lymphocytes to restore responsiveness to IL-7.

5 July 2018

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Minimally cultured tumor-infiltrating lymphocytes display optimal characteristics for adoptive cell therapy

5 July 2018

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Phenotype and functional characterization of long-term gp100-specific memory CD8+ T cells in disease-free melanoma patients before and after boosting immunization

5 July 2018

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Adoptive cell therapy for patients with melanoma, using tumor-infiltrating lymphocytes genetically engineered to secrete interleukin-2.

5 July 2018

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Tumor escape mechanism governed by myeloid-derived suppressor cells

5 July 2018

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IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy

5 July 2018

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Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates

5 July 2018

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T cell-encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection

5 July 2018

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CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867264

Co-expression of cytokine and suicide genes to enhance the activity and safety of tumor-specific cytotoxic T lymphocytes.

5 July 2018

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Cytokines and T-cell homeostasis

5 July 2018

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Comparison of common gamma-chain cytokines, interleukin-2, interleukin-7, and interleukin-15 for the in vitro generation of human tumor-reactive T lymphocytes for adoptive cell transfer therapy

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867264

Primary human T lymphocytes engineered with a codon-optimized IL-15 gene resist cytokine withdrawal-induced apoptosis and persist long-term in the absence of exogenous cytokine

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867264

Targeted elimination of prostate cancer by genetically directed human T lymphocytes

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867264

IL-21 influences the frequency, phenotype, and affinity of the antigen-specific CD8 T cell response

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867264

Development of 2A peptide-based strategies in the design of multicistronic vectors

5 July 2018

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Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells

5 July 2018

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Survival, persistence, and progressive differentiation of adoptively transferred tumor-reactive T cells associated with tumor regression

5 July 2018

1 reference

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Immunosuppressive networks in the tumour environment and their therapeutic relevance

5 July 2018

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Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867264

IL-21 enhances and sustains CD8+ T cell responses to achieve durable tumor immunity: comparative evaluation of IL-2, IL-15, and IL-21

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867264

The three Es of cancer immunoediting

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867264

IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867264

Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes

5 July 2018

1 reference

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Imaging TCR-dependent NFAT-mediated T-cell activation with positron emission tomography in vivo

5 July 2018

1 reference

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Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867264

Fatal leukemia in interleukin 15 transgenic mice follows early expansions in natural killer and memory phenotype CD8+ T cells.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867264

Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867264

Cancer patient T cells genetically targeted to prostate-specific membrane antigen specifically lyse prostate cancer cells and release cytokines in response to prostate-specific membrane antigen

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867264

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867264

The 5' untranslated region, signal peptide, and the coding sequence of the carboxyl terminus of IL-15 participate in its multifaceted translational control

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867264

Recombinant retroviruses pseudotyped with the vesicular stomatitis virus G glycoprotein mediate both stable gene transfer and pseudotransduction in human peripheral blood lymphocytes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867264

Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867264

Interleukin 7 generates antitumor cytotoxic T lymphocytes against murine sarcomas with efficacy in cellular adoptive immunotherapy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867264

IL-21 promotes survival and maintains a naive phenotype in human CD4+ T lymphocytes.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867264

Differential regulation of human IL-7 receptor alpha expression by IL-7 and TCR signaling

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867264

Overexpression of IL-21 promotes massive CD8+ memory T cell accumulation.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867264

Genetically targeted T cells eradicate systemic acute lymphoblastic leukemia xenografts

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867264

IL-21 induces apoptosis of antigen-specific CD8+ T lymphocytes.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867264

Four functionally distinct populations of human effector-memory CD8+ T lymphocytes.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867264

Ex vivo characterization of human CD8+ T subsets with distinct replicative history and partial effector functions

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867264

Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867264

Multifactorial optimization of gammaretroviral gene transfer into human T lymphocytes for clinical application

29 October 2018

1 reference

12 December 2020

Loss of CD28 expression on CD8(+) T cells is induced by IL-2 receptor gamma chain signalling cytokines and type I IFN, and increases susceptibility to activation-induced apoptosis

1 reference

12 December 2020

Proliferation and differentiation potential of human CD8+ memory T-cell subsets in response to antigen or homeostatic cytokines

1 reference

12 December 2020

IL-7-dependent extrathymic expansion of CD45RA+ T cells enables preservation of a naive repertoire

1 reference

12 December 2020

10.1182/BLOOD-2009-09-241398

Identifiers

DOI

1 reference

release_gd5a7ik3tvcx7fhrcw57x6hg6q

29 July 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/gd5a7ik3tvcx7fhrcw57x6hg6q

24 November 2022

mapped directly with Wikidata item

PMC publication ID

2867264

1 reference

29 July 2017

1 reference