Trivalent adenovirus type 5 HIV recombinant vaccine primes for modest cytotoxic capacity that is greatest in humans with protective HLA class I alleles (Q33839468)

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English	Trivalent adenovirus type 5 HIV recombinant vaccine primes for modest cytotoxic capacity that is greatest in humans with protective HLA class I alleles	scientific article

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Europe PubMed Central

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29 July 2017

Trivalent adenovirus type 5 HIV recombinant vaccine primes for modest cytotoxic capacity that is greatest in humans with protective HLA class I alleles (English)

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29 July 2017

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M Juliana McElrath

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Julia E Rood

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Daniel Mendoza

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Claire W Hallahan

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Claire W Hallahan

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Ann Duerr

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Nicole Frahm

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Stephen A Migueles

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Amy M Berkley

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Tiffany Guo

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Andy Patamawenu

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Nancy A Cogliano

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Mark Connors

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publication date

24 February 2011

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29 July 2017

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29 July 2017

e1002002

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29 July 2017

copyright license

Creative Commons CC0 License

24 February 2011

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copyrighted, dedicated to the public domain by copyright holder

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1 reference

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Phenotypic and functional profile of HIV-inhibitory CD8 T cells elicited by natural infection and heterologous prime/boost vaccination

1 reference

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Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand

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Defective human immunodeficiency virus-specific CD8+ T-cell polyfunctionality, proliferation, and cytotoxicity are not restored by antiretroviral therapy.

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Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge

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Comparisons of CD8+ T Cells Specific for Human Immunodeficiency Virus, Hepatitis C Virus, and Cytomegalovirus Reveal Differences in Frequency, Immunodominance, Phenotype, and Interleukin-2 Responsiveness

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Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control

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Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy.

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Mamu-B*08-positive macaques control simian immunodeficiency virus replication

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HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype

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Gag-specific CD8+ T lymphocytes recognize infected cells before AIDS-virus integration and viral protein expression

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Subdominant CD8+ T-cell responses are involved in durable control of AIDS virus replication

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Maintenance of viral suppression in HIV-1-infected HLA-B*57+ elite suppressors despite CTL escape mutations

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The high-frequency major histocompatibility complex class I allele Mamu-B*17 is associated with control of simian immunodeficiency virus SIVmac239 replication

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HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells

1 reference

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Toward understanding MHC disease associations: partial resequencing of 46 distinct HLA haplotypes

1 reference

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Attenuation of simian immunodeficiency virus SIVmac239 infection by prophylactic immunization with dna and recombinant adenoviral vaccine vectors expressing Gag

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HIV controllers: a homogeneous group of HIV-1-infected patients with spontaneous control of viral replication

1 reference

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HIV-1-specific IFN-gamma/IL-2-secreting CD8 T cells support CD4-independent proliferation of HIV-1-specific CD8 T cells.

1 reference

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Loss of HIV-1-specific CD8+ T cell proliferation after acute HIV-1 infection and restoration by vaccine-induced HIV-1-specific CD4+ T cells

1 reference

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Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load.

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Analysis of total human immunodeficiency virus (HIV)-specific CD4(+) and CD8(+) T-cell responses: relationship to viral load in untreated HIV infection

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HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors

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1 reference

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2 references

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https://pubmed.ncbi.nlm.nih.gov/21383976

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HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors

1 reference

https://pubmed.ncbi.nlm.nih.gov/21383976

12 December 2020

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10.1371/JOURNAL.PPAT.1002002

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Europe PubMed Central

PubMed publication ID

29 July 2017

PMC publication ID

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Europe PubMed Central

PubMed publication ID

29 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

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29 July 2017

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