STRADalpha deficiency results in aberrant mTORC1 signaling during corticogenesis in humans and mice (Q33815644)

29 July 2017

title

STRADalpha deficiency results in aberrant mTORC1 signaling during corticogenesis in humans and mice (English)

1 reference

29 July 2017

Ksenia A Orlova

1 reference

29 July 2017

Whitney E Parker

1 reference

29 July 2017

Gregory G Heuer

1 reference

29 July 2017

Victoria Tsai

1 reference

29 July 2017

Jason Yoon

1 reference

29 July 2017

Marianna Baybis

1 reference

29 July 2017

Robert S Fenning

1 reference

29 July 2017

Kevin Strauss

1 reference

29 July 2017

Peter B Crino

1 reference

29 July 2017

language of work or name

English

0 references

publication date

26 April 2010

1 reference

Journal of Clinical Investigation

29 July 2017

published in

1 reference

29 July 2017

volume

120

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29 July 2017

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29 July 2017

page(s)

1591-1602

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Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation

29 July 2017

cites work

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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Rapamycin causes regression of astrocytomas in tuberous sclerosis complex

4 July 2018

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Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2

4 July 2018

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4 July 2018

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Mammalian SAD kinases are required for neuronal polarization

4 July 2018

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The LKB1 tumor suppressor negatively regulates mTOR signaling

4 July 2018

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Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

4 July 2018

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Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD.

4 July 2018

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The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

4 July 2018

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LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

4 July 2018

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TSC2 mediates cellular energy response to control cell growth and survival

4 July 2018

1 reference

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MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

4 July 2018

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Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

4 July 2018

1 reference

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2860905

Management of cellular energy by the AMP-activated protein kinase system

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2860905

Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2860905

5-Aminoimidazole-4-carboxamide riboside induces apoptosis in Jurkat cells, but the AMP-activated protein kinase is not involved.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2860905

Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2860905

Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2860905

Growth arrest by the LKB1 tumor suppressor: induction of p21(WAF1/CIP1).

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2860905

Protean PTEN: form and function

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2860905

Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2860905

Translational induction of the c-myc oncogene via activation of the FRAP/TOR signalling pathway

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2860905

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2860905

Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2860905

In vivo electroporation in the embryonic mouse central nervous system

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2860905

Structure-specific patterns of neural stem cell engraftment after transplantation in the adult mouse brain.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2860905

mTOR cascade activation distinguishes tubers from focal cortical dysplasia

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2860905

Loss of cytoplasmic retention ability of mutant LKB1 found in Peutz-Jeghers syndrome patients

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20424326

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1172/JCI41592

1 reference

29 July 2017

1 reference

29 July 2017

1 reference