Redox signalling and transition metals in the control of the p53 pathway (Q33800722)

29 July 2017

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title

Redox signalling and transition metals in the control of the p53 pathway (English)

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29 July 2017

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Méplan C

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29 July 2017

Richard MJ

series ordinal

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29 July 2017

Hainaut P

series ordinal

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29 July 2017

language of work or name

English

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publication date

1 January 2000

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29 July 2017

published in

Biochemical Pharmacology

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29 July 2017

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29 July 2017

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29 July 2017

page(s)

25-33

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Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

29 July 2017

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Analysis of the most representative tumour-derived p53 mutants reveals that changes in protein conformation are not correlated with loss of transactivation or inhibition of cell proliferation.

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Temperature sensitivity for conformation is an intrinsic property of wild-type p53.

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Flexibility: the key to p53 function?

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Allosteric activation of latent p53 tetramers

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Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

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Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage

7 January 2021

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A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.

7 January 2021

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Tumor necrosis factor-induced apoptosis stimulates p53 accumulation and p21WAF1 proteolysis in ME-180 cells

7 January 2021

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p53 protein expression is correlated with benzo[a]pyrene-DNA adducts in carcinoma cell lines

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Mdm2 promotes the rapid degradation of p53

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Regulation of p53 stability by Mdm2

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Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

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DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

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DNA damage induces phosphorylation of the amino terminus of p53

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Radiation, DNA damage and cancer

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The DNA-dependent protein kinase

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The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

7 January 2021

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ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

7 January 2021

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7 January 2021

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Synergistic activation of transcription by CBP and p53

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p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage

7 January 2021

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ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

7 January 2021

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Identification of redox/repair protein Ref-1 as a potent activator of p53

7 January 2021

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The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains

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7 January 2021

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p53 inhibits hypoxia-inducible factor-stimulated transcription

7 January 2021

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The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots

7 January 2021

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Characterization of baculovirus recombinant wild-type p53. Dimerization of p53 is required for high-affinity DNA binding and cysteine oxidation inhibits p53 DNA binding

7 January 2021

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Divalent metal ions induce conformational change in pure, human wild-type p53 tumor suppressor protein

7 January 2021

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Effect of transition metals on binding of p53 protein to supercoiled DNA and to consensus sequence in DNA fragments.

7 January 2021

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7 January 2021

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Pyrrolidine dithiocarbamate prevents p53 activation and promotes p53 cysteine residue oxidation.

7 January 2021

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Regulation of p53 by metal ions and by antioxidants: dithiocarbamate down-regulates p53 DNA-binding activity by increasing the intracellular level of copper.

7 January 2021

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1 Introduction to metallothionein

7 January 2021

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A p53-independent Pathway for Activation of WAF1/CIP1 Expression Following Oxidative Stress

7 January 2021

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Redox state regulates binding of p53 to sequence-specific DNA, but not to non-specific or mismatched DNA.

7 January 2021

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Redox gene therapy for ischemia/reperfusion injury of the liver reduces AP1 and NF-kappaB activation.

7 January 2021

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Cooperation of protein disulfide isomerase and redox environment in the regulation of NF-kappaB and AP1 binding to DNA

7 January 2021

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Cell cycle regulation of metallothionein in human colonic cancer cells

7 January 2021

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10.1016/S0006-2952(99)00297-X

7 January 2021

Identifiers

DOI

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29 July 2017

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